Background: People with Multiple Sclerosis (MS) experience problems in the level of perceived occupational performance and satisfaction in activities of daily living due to the negative effects of factors such as physical, cognitive, social and environmental. Aim: This study was planned to examine the effectiveness of the client-centered training for people with MS on perceived occupational performance and satisfaction. Method: Fourteen MS individuals, 10 females and 4 males participated to the study. According to Canadian Occupational Performance Measure (COPM), a training program designed according to the occupations that indicated by participants. A training program consists of 24 sessions of 45 minutes, 4 days a week for 6 weeks. Results: The mean COPM performance of people with MS before the training was median 3.60, COPM satisfaction was median 3.22. After the training, COPM performance was median 7.35, and COPM satisfaction was median 8.00. Before and after training COPM performance and COPM satisfaction statistically increased (p<0.01). When the distributions of occupations examined, it is determined that self-care 55.17%, productivity 24.13% and leisure 20.68%. Conclusions: Client-centered training for people with MS had positive effects on perceived occupational performance and satisfaction. It is thought that client-centered training can be used effectively to increase the occupational performance and satisfaction determined by people with MS.