Strong independent association between obesity and essential hypertension

Abstract

Obesity and hypertension (HTN) are major risk factors for cardiovascular disease. Association between obesity and HTN has not been studied in a large populations following adjustment for comorbidities. The goal of this study was to evaluate any association between obesity and HTN after adjusting for baseline characteristics. We used ICD-9 codes for obesity and HTN from the Nationwide Inpatient Sample (NIS) databases. Two randomly selected years, 1992 and 2002, were chosen from the databases as two independent samples. We used uni- and multivariable analysis to study any correlation between obesity and HTN. The 1992 database contained a total of 6,195,744 patients. HTN was present in 37.2 % of patients with obesity versus 12% of the control group (OR: 4.36, CI 4.30-4.42, P < 0.001). The 2002 database contained a total of 7,153,982 patients. HTN was present in 50.7% of patients with obesity versus 25.6% of the control group (OR: 2.98, CI 2.96-3.00, P < 0.001). Using multivariable analysis adjusting for gender, hyperlipidaemia, age, smoking, type 2 diabetes and chronic renal failure, obesity remained correlated with HTN in both years (1992: OR 2.69, CI 2.67-2.72, P < 0.001; 2002: OR 2.98, CI 2.96-3.00, P < 0.001). The presence of obesity was found to be strongly and independently associated with HTN. The cause of this correlation is not known warranting further investigation.

A Study on Somatic Dna Damages in Hypertensive Young Adults and Its Correlation With Biochemicaland Demographic Parame

“…The mean values of BMI and abdominal circumference was higher in cases compared to controls in the present study clearly demonstrating the association of obesity with hypertension which is supported by the observations of studies by Gupta and Kapoor 2010 and Movahed et al 2016 [23,24]. While performing Pearson correlation, BMI and abdominal circumference showed a positive correlation with CBMN frequency pointing out that DNA damages are signicantly higher in obese individuals.…”

Association of hypertension with generalized obesity in rural south-western Nigeria

“…This may be due to the older age, and higher prevalence of obesity among the females. Hypertension is known to be strongly associated with age and obesity [10,28]. The World Health Organization also reported a higher prevalence of hypertension in Nigerian females [27].…”

“…It constitutes a major public health challenge because of its co-morbidities. General obesity is strongly associated with arterial hypertension [10], which is increasing in some populations [11]. Several authors [12][13][14][15][16] have documented the association of obesity and hypertension, and the link is attributed to increased leptin, low adiponectin, activation of rennin-angiotensin-aldosterone system, increased sympathetic drive, sodium retention, and endothelial dysfunction [17].…”

Unifferentiated Connective Tissue Dysplasia as a Potential Predictor of Arterial Hypertension Development in Patients With Type 2 Diabetes Mellitus

“…Arterial hypertension (AG) is one of the most common cardiovascular diseases that afflicts more than 1.5 billion people in the world, with almost 45 % of them being not aware of the presence of high blood pressure (BP) [1]. Hypertension is often manifested in combination with another pathology, in particular, with diabetes mellitus (DM), obesity, coronary heart disease (CHD), chronic kidney disease (CKD), heart failure (CH), and others [2][3]. The most often combination is hypertension and diabetes.…”