Strong terahertz (THz) radiation provides a powerful tool to manipulate and control complex condensed matter systems. This review provides an overview of progress in the generation, detection, and applications of intense THz radiation. The tabletop intense THz sources based on Ti:sapphire laser are reviewed, including photoconductive antennas (PCAs), optical rectification sources, plasma-based THz sources, and some novel techniques for THz generations, such as topological insulators, spintronic materials, and metasurfaces. The coherent THz detection methods are summarized, and their limitations for intense THz detection are analyzed. Applications of intense THz radiation are introduced, including applications in spectroscopy detection, nonlinear effects, and switching of coherent magnons. The review is concluded with a short perspective on the generation and applications of intense THz radiation.