2011
DOI: 10.1063/1.3626786
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Strongly coupled bio-plasmonic system: Application to oxygen sensing

Abstract: We investigate theoretically the strong coupling between surface plasmon resonances (SPRs) and absorption bands of hemoglobin. When the surface plasmon resonance spectrally overlaps the absorption bands of hemoglobin, the system is strongly coupled and its dispersion diagram exhibits an anti-crossing. Working in the conditions of strong coupling enhances the sensitivity of a SPR sensor up to a factor of 10. A model for the permittivity of hemoglobin, both in oxygenated and deoxygenated states, is presented and… Show more

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Cited by 7 publications
(5 citation statements)
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“…Recent developments in nanotechnology have led to the realization of new optical sensors that can measure a broad range of analytes in both liquid and gaseous forms. Sensors based on surface plasmon resonances have attracted significant attention for chemical and biological sensing applications, thanks to their ability to confine light at the nanoscale well below the diffraction limit, which provides record sensitivity and low noise . Plasmons supported by thin films (excited via Otto or Kretschmann configuration), plasmonic resonators, nanocavities, , nanoparticles, nanocluster, nanopillars, nanoantennas, and nanorods are some of the numerous configurations for plasmonic sensors which have been suggested to take advantage of the field localization in the subwavelength sensing region. All these devices are designed to enhance the refractive index sensitivity, which is defined as the ratio of the shift in resonance wavelength to the change in the refractive index of the analyte .…”
mentioning
confidence: 99%
“…Recent developments in nanotechnology have led to the realization of new optical sensors that can measure a broad range of analytes in both liquid and gaseous forms. Sensors based on surface plasmon resonances have attracted significant attention for chemical and biological sensing applications, thanks to their ability to confine light at the nanoscale well below the diffraction limit, which provides record sensitivity and low noise . Plasmons supported by thin films (excited via Otto or Kretschmann configuration), plasmonic resonators, nanocavities, , nanoparticles, nanocluster, nanopillars, nanoantennas, and nanorods are some of the numerous configurations for plasmonic sensors which have been suggested to take advantage of the field localization in the subwavelength sensing region. All these devices are designed to enhance the refractive index sensitivity, which is defined as the ratio of the shift in resonance wavelength to the change in the refractive index of the analyte .…”
mentioning
confidence: 99%
“…Other parameters were chosen as: λ 0 =0.5770 μm, ε 2 = ε 4 =3.9085, d 2 =d 4 =0.5*λ 0 /(ε 2 ) 0.5 =0.1459 μm, ε 3 =2.2883 and ε i = ε f =6.145. The incident wavelength λ 0 is chosen such that it coincides with one of the Q-bands of oxygenated Hemoglobin (at 0.5770 μm) [17]. We first study the dispersion characteristics assuming a plane wave illumination with a goal to delineate the under coupled, critically coupled (with a flat dip in the reflectivity profile) and over coupled (with distinct split resonances) regimes.…”
Section: Resultsmentioning
confidence: 99%
“…Surface plasmons (SPs) are electromagnetic modes that are confined to the metal–dielectric interface and are caused by the resonant oscillations of free electrons. , Typically, nanostructures can support propagating SPs and localized SPs depending on the geometrical parameters, materials employed, and excitation conditions used. , The SP fields are evanescent in nature and decay exponentially away from the interface into both metal and dielectric medium. , Propagating SPs can be excited at the metal–dielectric interface using special geometries that enable the matching of SP momentum with that of incident light. Propagating SPs have been used in label-free SPR optical biosensors to detect various biomolecules and have also been applied for studying the kinetics of molecular processes in real time. Moreover, these evanescent SP fields have been utilized for realizing superlenses with imaging capability beyond the diffraction limit . On the other hand, localized SPs can be excited using plane wave illumination.…”
Section: Introductionmentioning
confidence: 99%