Strontium- and Cobalt-Doped Multicomponent Mesoporous Bioactive Glasses (MBGs) for Potential Use in Bone Tissue Engineering Applications

Kermani, Farzad; Mollazadeh, Samaneh; Baino, Francesco; Gholamzadeh-Virany, Zahra; Mozafari, Masoud; Kargozar, Saeid

doi:10.3390/ma13061348

Cited by 58 publications

(41 citation statements)

References 51 publications

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“…The release of Sr 2+ and Co 2+ ions occurred from the relevant PCL/BG-Sr, PCL/BG-CaCo, and PCL/BG-SrCo scaffolds. The higher release of Sr 2+ and Co 2+ ions from PCL/BG-SrCo scaffolds compared to the other batches can be attributed to the higher concentration of structural defects in these BGs and is in line with our previous study [13].…”

Section: Ion Release Profilesupporting

confidence: 91%

“…In order to further improve the biological activity of BGs and their composites, innovative glass formulations are currently developed by incorporating metallic dopants with specific therapeutic properties [12]. In this regard, strontium-and cobalt-doped BGs were reported suitable materials in BTE application due to their ability to simultaneously accelerate osteogenesis and angiogenesis [13][14][15].…”

Section: Introductionmentioning

confidence: 99%

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Three-dimensionally printed polycaprolactone/multicomponent bioactive glass scaffolds for potential application in bone tissue engineering

et al. 2020

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Over the last years, three-dimensional (3D) printing has been successfully applied to produce suitable substitutes for treating bone defects. In this work, 3D printed composite scaffolds of polycaprolactone (PCL) and strontium (Sr)- and cobalt (Co)-doped multi-component melt-derived bioactive glasses (BGs) were prepared for bone tissue engineering strategies. For this purpose, 30% of as-prepared BG particles (size <38 μm) were incorporated into PCL, and then the obtained composite mix was introduced into a 3D printing machine to fabricate layer-by-layer porous structures with the size of 12 × 12 × 2 mm3.The scaffolds were fully characterized through a series of physico-chemical and biological assays. Adding the BGs to PCL led to an improvement in the compressive strength of the fabricated scaffolds and increased their hydrophilicity. Furthermore, the PCL/BG scaffolds showed apatite-forming ability (i.e., bioactivity behavior) after being immersed in simulated body fluid (SBF). The in vitro cellular examinations revealed the cytocompatibility of the scaffolds and confirmed them as suitable substrates for the adhesion and proliferation of MG-63 osteosarcoma cells. In conclusion, 3D printed composite scaffolds made of PCL and Sr- and Co-doped BGs might be potentially-beneficial bone replacements, and the achieved results motivate further research on these materials.

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Section: Ion Release Profilesupporting

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Three-dimensionally printed polycaprolactone/multicomponent bioactive glass scaffolds for potential application in bone tissue engineering

et al. 2020

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“…The incorporation of MBGs in thermoplastic matrices is not as common as for HA, but studies involving their mixing with PCL (Yun et al, 2011) and Poly(3-hydroxybutyrateco-3-hydroxyhexanoate) (PHBHHx) (Zhao et al, 2014) report successful cell growth and proliferation. Moreover, based on previous assessments (Baino and Fiume, 2020;Kermani et al, 2020), the MBGs are characterized not only by an excellent biocompatibility, but also by an osteogenic potential, desirable in bone healing devices.…”

Section: The Extrusion Process and Final Properties Of The Hybrid Filmentioning

confidence: 99%

Processing of Sr2+ Containing Poly L-Lactic Acid-Based Hybrid Composites for Additive Manufacturing of Bone Scaffolds

et al. 2020

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Biodegradable composite materials represent one of the major areas of investigation for bone tissue engineering due to their tuneable compositional and mechanical properties, which can potentially mimic those of bone and potentially avoid the removal of implants, mitigating the risks for the patient and reducing the overall clinical costs. In addition, the introduction of additive manufacturing technologies enables a strict control over the final morphological features of the scaffolds. In this scenario, the optimisation of 3D printable resorbable composites, made of biocompatible polymers and osteoinductive inorganic phases, offers the potential to produce a chemically and structurally biomimetic implant, which will resorb over time. The present work focuses on the development and process optimisation of two hybrid composite filaments, to be used as feedstock for the fused filament fabrication 3D printing process. A Poly L-lactic acid matrix was blended with either rod-like nano-hydroxyapatite (nano-HA) or nanoparticles of mesoporous bioactive glasses, both partially substituted with strontium (Sr2+), due to the well-known pro-osteogenic effect of this ion. Both inorganic phases were incorporated into Poly L-lactic acid using an innovative combination of processes, obtaining a homogeneous distribution throughout the polymer whilst preserving their ability to release Sr2+. The filament mechanical properties were not hindered after the incorporation of the inorganic phases, resulting in tensile strengths and moduli within the range of cancellous bone, 50 ± 10 MPa and 3 ± 1 GPa. Finally, the rheological characterization of the hybrid composites indicated a shear thinning behaviour, ideal for the processing with fused filament fabrication, proving the potential of these materials to be processed into 3D structures aiming bone regeneration.

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“…In general terms, MBGs offer suitable platforms for drug/ion delivery which increases the range of possible uses in the biomedical field. For example, incorporation of strontium for the treatment of osteoporosis, cobalt to enhance the pro-angiogenic effects, and copper to improve angiogenesis and immune responses [ 118 , 119 ].…”

Section: Resultsmentioning

confidence: 99%

Mesoporous Bioactive Glasses Cytocompatibility Assessment: A Review of In Vitro Studies

et al. 2021

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Thanks to their high porosity and surface area, mesoporous bioactive glasses (MBGs) have gained significant interest in the field of medical applications, in particular, with regards to enhanced bioactive properties which facilitate bone regeneration. The aim of this article is to review the state of the art regarding the biocompatibility evaluation of MBGs and provide a discussion of the various approaches taken. The research was performed using PubMed database and covered articles published in the last five years. From a total of 91 articles, 63 were selected after analyzing them according to our inclusion and exclusion criteria. In vitro methodologies and techniques used for biocompatibility assessment were investigated. Among the biocompatibility assessment techniques, scanning electron microscopy (SEM) has been widely used to study cell morphology and adhesion. Viability and proliferation were assessed using different assays including cell counting and/or cell metabolic activity measurement. Finally, cell differentiation tests relied on the alkaline phosphatase assay; however, these were often complemented by specific bimolecular tests according to the exact application of the mesoporous bioactive glass. The standardization and validation of all tests performed for MBG cytocompatibility is a key aspect and crucial point and should be considered in order to avoid inconsistencies, bias between studies, and unnecessary consumption of time. Therefore, introducing standard tests would serve an important role in the future assessment and development of MBG materials.

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Strontium- and Cobalt-Doped Multicomponent Mesoporous Bioactive Glasses (MBGs) for Potential Use in Bone Tissue Engineering Applications

Cited by 58 publications

References 51 publications

Three-dimensionally printed polycaprolactone/multicomponent bioactive glass scaffolds for potential application in bone tissue engineering

Three-dimensionally printed polycaprolactone/multicomponent bioactive glass scaffolds for potential application in bone tissue engineering

Processing of Sr2+ Containing Poly L-Lactic Acid-Based Hybrid Composites for Additive Manufacturing of Bone Scaffolds

Mesoporous Bioactive Glasses Cytocompatibility Assessment: A Review of In Vitro Studies

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