Strontium-based Glass Polyalkenoate Cements for Luting Applications in the Skeleton

Clarkin, Owen; Boyd, Daniel; Towler, Mark R.

doi:10.1177/0885328208099085

Cited by 28 publications

(29 citation statements)

References 55 publications

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“…Strength increases over time (maturation) as a result of the ions released from the glass chelating with the COO- from the acid component [ 34 , 35 , 36 , 37 ], through a continuous acid-base reaction [ 33 ]. In this study, in addition to maturation, strengths also increased with Ge content.…”

Section: Resultsmentioning

confidence: 99%

An Injectable Glass Polyalkenoate Cement Engineered for Fracture Fixation and Stabilization

Khader

Peel

Towler

2017

JFB

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Glass polyalkenoate cements (GPCs) have potential as bio-adhesives due to their ease of application, appropriate mechanical properties, radiopacity and chemical adhesion to bone. Aluminium (Al)-free GPCs have been discussed in the literature, but have proven difficult to balance injectability with mechanical integrity. For example, zinc-based, Al-free GPCs reported compressive strengths of 63 MPa, but set in under 2 min. Here, the authors design injectable GPCs (IGPCs) based on zinc-containing, Al-free silicate compositions containing GeO2, substituted for ZnO at 3% increments through the series. The setting reactions, injectability and mechanical properties of these GPCs were evaluated using both a hand-mix (h) technique, using a spatula for sample preparation and application and an injection (i) technique, using a 16-gauge needle, post mixing, for application. GPCs ability to act as a carrier for bovine serum albumin (BSA) was also evaluated. Germanium (Ge) and BSA containing IGPCs were produced and reported to have working times between 26 and 44 min and setting times between 37 and 55 min; the extended handling properties being as a result of less Ge. The incorporation of BSA into the cement had no effect on the handling and mechanical properties, but the latter were found to have increased compression strength with the addition of Ge from between 27 and 37 MPa after 30 days maturation.

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Section: Resultsmentioning

confidence: 99%

An Injectable Glass Polyalkenoate Cement Engineered for Fracture Fixation and Stabilization

Khader

Peel

Towler

2017

JFB

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“…The inclusion of particle sizes in the submicron range leads to higher packing densities and may lead to sintering occurring at lower temperatures than those with a larger particle size distribution. 37 The shrinkage profile for each of the materials studied are shown in Figures 3, 4, and 5, where each material shows a distinct densification profile. BT110 shows a profile where at 580 C approximately shrinkage begins.…”

Section: Discussionmentioning

confidence: 99%

An evaluation of the processing conditions, structure, and properties (biaxial flexural strength and antibacterial efficacy) of sintered strontium–zinc–silicate glass ceramics

et al. 2011

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The use of artificial bone grafts has increased in order to satisfy a growing demand for bone replacement materials. Initial mechanical stability of synthetic bone grafts is very advantageous for certain clinical applications. Coupled with the advantage of mechanical strength, a material with inherent antibacterial properties would be very beneficial. A series of strontium-doped zinc silicate (Ca-Sr-Na-Zn-Si) glass ceramics have been characterized in terms of their crystalline structure, biaxial flexural strength and antibacterial efficacy based on the identification of optimum sintering conditions. All three glass ceramics, namely, BT110, BT111, and BT112 were found to be fully crystalline, with BT111 and BT112 comprising of biocompatible crystalline phases. The biaxial flexural strengths of the three glass ceramics ranged from 70 to 149 MPa and were shown to be superior to those of clinically established ceramics in dry conditions and following incubation in simulated physiological conditions. The bacteriostatic effect for each glass ceramic was also established, where BT112 showed an inhibitory effect against three of the most common bacteria found at implantation sites, namely, Enterococcus faecalis, methicillin-resistant Staphylococcus aureus (MRSA), and Pseudomonas aeruginosa. The results of the evaluation suggest that the materials studied offer advantages over current clinical materials and indicate the potential suitability of the glass ceramics as therapeutic bone grafts.

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“…In addition, Sr and Mg have been used to reduce the solubility of the glass network and alter the formation and morphology of the HCA layer [11,19,20]. The diversity of modifying elements that can be incorporated into the Si network of bioactive glasses gives rise to their many applications, such as particulates for bone void filling, glass microspheres for drug delivery, pastes/cements in dental and spinal applications, bone adhesives, scaffolds [15,[21][22][23], and more recently, they have been applied in composite guides for nerve regeneration [24,25]. The regeneration of nerves, specifically after spinal cord injury (SCI), is of particular interest, and there are many research activities currently aimed at aiding the regeneration and reconnection of these nerves.…”

Section: Introductionmentioning

confidence: 99%

Characterization of Y2O3 and CeO2 doped SiO2-SrO-Na2O glasses

Placek¹,

Keenan²,

Laffir³

et al. 2015

Biomedical Glasses

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Abstract:The structural effects of yttrium (Y) and cerium (Ce) are investigated when substituted for sodium (Na) in a 0.52SiO 2 -0.24SrO-(0.24−x)Na 2 O-xMO (where x = 0.08; MO = Y 2 O 3 and CeO 2 ) glass series. Network connectivity (NC) was calculated assuming both Y and Ce can act as a network modifier (NC = 2.2) or as a network former (NC up to 2.9). Thermal analysis showed an increase in glass transition temperature (Tg) with increasing Y and Ce content, Y causing the greater increase from the control (Con) at 493 ∘ C to 8 mol% Y (HY) at 660 ∘ C. Vickers hardness (HV)was not significantly different between glasses. 29 Si MagicAngle Spinning-Nuclear Magnetic Resonance (MAS-NMR) did not show peak shift with addition of Y, however Ce produced peak broadening and a negative shift in ppm. The addition of 4 mol% Ce in the YCe and LCe glasses shifted the peak from Con at −81.3 ppm to −82.8 ppm and −82.7 ppm respectively; while the HCe glass produced a much broader peak and a shift to −84.8 ppm. High resolution X-ray Photoelectron Spectroscopy for the O 1s spectral line showed the ratio of bridging (BO) to non-bridging oxygens (NBO), BO:NBO, was altered, where Con had a ratio of 0.7, HY decreased to 0.4 and HCe to 0.5.

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Strontium-based Glass Polyalkenoate Cements for Luting Applications in the Skeleton

Cited by 28 publications

References 55 publications

An Injectable Glass Polyalkenoate Cement Engineered for Fracture Fixation and Stabilization

An Injectable Glass Polyalkenoate Cement Engineered for Fracture Fixation and Stabilization

An evaluation of the processing conditions, structure, and properties (biaxial flexural strength and antibacterial efficacy) of sintered strontium–zinc–silicate glass ceramics

Characterization of Y2O3 and CeO2 doped SiO2-SrO-Na2O glasses

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