Strontium biokinetic model for the lactating woman and transfer to breast milk: application to Techa River studies

Shagina, N. B.; Толстых, Е. И.; Fell, Timothy; Smith, T.; Harrison, John

doi:10.1088/0952-4746/35/3/677

Cited by 9 publications

(4 citation statements)

References 56 publications

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“…The doses due to intakes of short-lived radionuclides were considered. Breast milk as a source of 89,90 Sr and 137 Cs for infants was taken into account [ 17 ]. In current cancer risk analysis, the stomach dose resulting from postnatal exposure was used as a proxy of the postnatal dose to soft tissues, because of the high prevalence of stomach cancer and also the fact that the ratio of the dose accumulated in most organs to the stomach dose is close to 1.…”

Section: Methodsmentioning

confidence: 99%

Incidence and Mortality of Solid Cancers in People Exposed In Utero to Ionizing Radiation: Pooled Analyses of Two Cohorts from the Southern Urals, Russia

et al. 2016

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BackgroundPrevious studies have shown that acute external in utero exposure to ionizing radiation can increase cancer risk. It is not known whether chronic exposure at low dose rates, including due to radionuclide intake, influences the lifetime risk of solid cancers in the offspring. The objective of this study was to investigate solid cancer risk after in utero irradiation.MethodsCancer incidence and mortality over a 60-year period (from January 1950 to December 2009) were analyzed in the Urals Prenatally Exposed Cohort (UPEC). The cohort comprised in utero exposed offspring of Mayak Production Association female workers and of female residents of Techa River villages. Some of the offspring also received postnatal exposure, either due to becoming radiation workers themselves or due to continuing to live in the contaminated areas of the Techa River. The mortality analyses comprised 16,821 subjects (601,372 person-years), and the incidence analyses comprised 15,813 subjects (554,411 person-years). Poisson regression was used to quantify the relative risk as a function of the in utero soft tissue dose (with cumulative doses up to 944.9 mGy, mean dose of 14.1 mGy in the pooled cohort) and the postnatal stomach dose for solid cancer incidence and mortality.ResultsWhen a log-linear model was used, relative risk of cancer per 10 mGy of in utero dose was 0.99 (95% confidence interval (CI) = 0.96 to 1.01) based on incidence data and 0.98 (CI = 0.94 to 1.01) based on mortality data. Postnatal exposure to ionizing radiation was positively associated with the solid cancer risk in members of the UPEC, with a relative risk of 1.02 per 10mGy CI = 1.00 to 1.04).ConclusionsNo strong evidence was found that chronic low-dose-rate exposure of the embryo and fetus increased the risk of solid cancers in childhood or in adulthood. For both incidence and mortality, a tendency towards a decreased relative risk was noted with increasing doses to soft tissues of the fetus. Further follow-up will provide more precise radiation risk estimates of solid cancer as cohort members are approaching their 60s and cancer becomes more common.

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Section: Methodsmentioning

confidence: 99%

Incidence and Mortality of Solid Cancers in People Exposed In Utero to Ionizing Radiation: Pooled Analyses of Two Cohorts from the Southern Urals, Russia

et al. 2016

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“…Postnatal exposure was estimated using the same system for individuals who continued to live in the contaminated areas or who were evacuated (as exposure because of bone-seeking strontium-90 continued long after intake regardless of place of residence). Breast milk, another source of radionuclides for infants, was also taken into account (Shagina et al , 2015b). Strontium-89 and strontium-90 exposure accounts for ∼90% of the total red bone marrow dose.…”

Section: Methodsmentioning

confidence: 99%

In utero exposure to radiation and haematological malignancies: pooled analysis of Southern Urals cohorts

et al. 2016

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Background:It is scientifically uncertain whether in utero exposure to low-dose ionising radiation increases the lifetime risk of haematological malignancies.Methods:We pooled two cohorts from the Southern Urals comprising offspring of female workers of a large nuclear facility (the Mayak Production Association) and of women living in areas along the Techa River contaminated by nuclear accidents/waste from the same facility, with detailed dosimetry.Results:The combined cohort totalled 19 536 subjects with 700 504 person-years at risk over the period of incidence follow-up, and slightly more over the period of mortality follow-up, yielding 58 incident cases and 36 deaths up to age 61 years. Risk was increased in subjects who received in utero doses of ⩾80 mGy (excess relative risk (ERR): 1.27; 95% confidence interval (CI): −0.20 to 4.71), and the risk increased consistently per 100 mGy of continuous exposure in utero (ERR: 0.77; CI: 0.02 to 2.56). No association was apparent in mortality-based analyses. Results for leukaemia and lymphoma were similar. A very weak positive association was observed between incidence and postnatal exposure.Conclusions:In summary, the results suggest a positive association between in utero exposure to ionising radiation and risk of haematological malignancies, but the small number of outcomes and inconsistent incidence and mortality findings preclude firm conclusions.

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“…There is no evidence of the nutritional importance of this element, although it is known that it is concentrated in the bone mass [11]. Biokinetic model for strontium in the lactating woman from bone to milk have been described [73]. Concentrations in human milk varying between 44 and 46 μg/L are reported [72].…”

Section: Strontiummentioning

confidence: 99%

Trace Elements in the Human Milk

Pinto¹

2018

Trace Elements - Human Health and Environment

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Human breast milk is considered to be the perfect food for infants, specifically adapted to their needs. Before birth, the mother transfers all the nutrients and bioactive components to the fetus through the placenta. After birth, these substances have to be transferred through colostrum and milk. In particular, human breast milk is supposed to provide all the essential trace elements that are required by the normal term newborn infant. Therefore, the composition of human breast milk and its changes during lactation is a topic of major importance and has been the subject for intensive research. Conversely, human milk can also be a transfer medium of undesirable (toxic) elements from the mother to the infant. An extensive review of the most recent literature was carried out focusing on the current trace elements levels and their changes during lactation. For several elements, there is a consistent knowledge of their characteristic concentrations throughout the various stages of lactation, their dependence on maternal nutritional status, inter-individual and geographical variability, metabolic pathways, inter-elemental relationships, and effects on child development. For many other elements, this knowledge does not exist or is quite limited.

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Strontium biokinetic model for the lactating woman and transfer to breast milk: application to Techa River studies

Cited by 9 publications

References 56 publications

Incidence and Mortality of Solid Cancers in People Exposed In Utero to Ionizing Radiation: Pooled Analyses of Two Cohorts from the Southern Urals, Russia

Incidence and Mortality of Solid Cancers in People Exposed In Utero to Ionizing Radiation: Pooled Analyses of Two Cohorts from the Southern Urals, Russia

In utero exposure to radiation and haematological malignancies: pooled analysis of Southern Urals cohorts

Trace Elements in the Human Milk

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