Strontium-doped hydroxyapatite and its role in osteogenesis and angiogenesis

Ran, Ling; Liu, Lishuang; Gao, Jingjing; Pan, Yang; Ramalingam, Murugan; Du, Xiaoyu; Liu, Ying; Cheng, Lijia; Shi, Zheng

doi:10.1387/ijdb.230091lc

Cited by 5 publications

(2 citation statements)

References 88 publications

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“…SrHA stimulates the formation of new bone by bone marrow stem cells (BMSCs), minimizes the time required for bone healing, and improves the integration of implants with the surrounding bone tissue. 25 …”

Section: Introductionmentioning

confidence: 99%

On the Ion Implantation Synthesis of Ag-Embedded Over Sr-Substituted Hydroxyapatite on a Nano-Topography Patterned Ti for Application in Acetabular Fracture Sites

Swain,

Pradhan,

Bhuyan

et al. 2024

IJN

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There is an ongoing need for improved healing response and expedited osseointegration on the Ti implants in acetabular fracture sites. To achieve adequate bonding and mechanical stability between the implant surface and the acetabular fracture, a new coating technology must be developed to promote bone integration and prevent bacterial growth. Methods: A cylindrical Ti substrate mounted on a rotating specimen holder was used to implant Ca 2+ , P 2+ , and Sr 2+ ions at energies of 100 KeV, 75 KeV and 180 KeV, respectively, using a low-energy accelerator to synthesize strontium-substituted hydroxyapatite at varying conditions. Ag 2+ ions of energy 100 KeV were subsequently implanted on the as-formed surface at the near-surface region to provide anti-bacterial properties to the as-formed specimen. Results:The properties of the as-formed ion-implanted specimen were compared with the SrHA-Ag synthesized specimens by cathodic deposition and low-temperature high-speed collision technique. The adhesion strength of the ion-implanted specimen was 43 ± 2.3 MPa, which is well above the ASTM standard for Ca-P coating on Ti. Live/dead cell analysis showed higher osteoblast activity on the ion-implanted specimen than the other two. Ag in the SrHA implanted Ti by ion implantation process showed superior antibacterial activity. Discussion: In the ion implantation technique, nano-topography patterned surfaces are not concealed after implantation, and their efficacy in interacting with the osteoblasts is retained. Although all three studies examined the antibacterial effects of Ag 2+ ions and the ability to promote bone tissue formation by MC3T3-E1 cells on SrHA-Ag/Ti surfaces, ion implantation techniques demonstrated superior ability. The synthesized specimen can be used as an effective implant in acetabular fracture sites based on their mechanical and biological properties.

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Section: Introductionmentioning

confidence: 99%

On the Ion Implantation Synthesis of Ag-Embedded Over Sr-Substituted Hydroxyapatite on a Nano-Topography Patterned Ti for Application in Acetabular Fracture Sites

Swain,

Pradhan,

Bhuyan

et al. 2024

IJN

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“…Additionally, the presence of Sr 2+ ions in the CPs-based implants can positively impact bone tissue due to their physiological similarity to calcium ions [19]. The presence of Sr 2+ ions in the implant can stimulate osteogenesis [20], and increase adhesion, proliferation and differentiation of osteoblasts [21,22]. The controlled release of a specific amount of Sr 2+ ions can facilitate the healing of osteoporotic bone defects [23].…”

Section: Introductionmentioning

confidence: 99%

Strontium and Copper Co-Doped Multifunctional Calcium Phosphates: Biomimetic and Antibacterial Materials for Bone Implants

Lebedev,

Kharovskaya,

Lazoryak

et al. 2024

Biomimetics

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β-tricalcium phosphate (β-TCP) is a promising material in regenerative traumatology for the creation of bone implants. Previously, it was established that doping the structure with certain cations can reduce the growth of bacterial activity. Recently, much attention has been paid to co-doped β-TCP, that is explained by their ability, on the one hand, to reduce cytotoxicity for cells of the human organism, on the other hand, to achieve a successful antibacterial effect. Sr, Cu-co-doped solid solutions of the composition Ca9.5–xSrxCu(PO4)7 was obtained by the method of solid-phase reactions. The Rietveld method of structural refinement revealed the presence of Sr2+ ions in four crystal sites: M1, M2, M3, and M4. The M5 site is completely occupied by Cu2+. Isomorphic substitution of Ca2+ → (Sr2+and Cu2+) expands the concentration limits of the existence of the solid solution with the β-TCP structure. No additional phases were formed up to x = 4.5 in Ca9.5–xSrxCu(PO4)7. Biocompatibility tests were performed on cell lines of human bone marrow mesenchymal stromal cells (hMSC), human fibroblasts (MRC-5) and osteoblasts (U-2OS). It was demonstrated that cytotoxicity exhibited a concentration dependence, along with an increase in osteogenesis and cell proliferation. Ca9.5–xSrxCu(PO4)7 powders showed significant inhibitory activity against pathogenic strains Escherichia coli and Staphylococcus aureus. Piezoelectric properties of Ca9.5–xSrxCu(PO4)7 were investigated. Possible ways to achieve high piezoelectric response are discussed. The combination of bioactive properties of Ca9.5–xSrxCu(PO4)7 renders them multifunctional materials suitable for bone substitutes.

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Synthesis of strontium and manganese co-doped hydroxyapatite nanoparticles by ultrasound-supported hydrothermal technique and Taguchi design of experiments for biomedical applications

Joshi,

Baraiya,

Shah

2024

Ceramics International

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Strontium-doped hydroxyapatite and its role in osteogenesis and angiogenesis

Cited by 5 publications

References 88 publications

On the Ion Implantation Synthesis of Ag-Embedded Over Sr-Substituted Hydroxyapatite on a Nano-Topography Patterned Ti for Application in Acetabular Fracture Sites

On the Ion Implantation Synthesis of Ag-Embedded Over Sr-Substituted Hydroxyapatite on a Nano-Topography Patterned Ti for Application in Acetabular Fracture Sites

Strontium and Copper Co-Doped Multifunctional Calcium Phosphates: Biomimetic and Antibacterial Materials for Bone Implants

Synthesis of strontium and manganese co-doped hydroxyapatite nanoparticles by ultrasound-supported hydrothermal technique and Taguchi design of experiments for biomedical applications

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