Strontium ranelate-laden near-infrared photothermal-inspired methylcellulose hydrogel for arthritis treatment

Chiang, Chih Wei; Hsiao, Yu Cheng; Jheng, Pei Ru; Chen, Chih-Hwa; Manga, Yankuba B.; Lekha, R.; Chao, Kun-Mao; Ho, Yi Cheng; Chuang, Er Yuan

doi:10.1016/j.msec.2021.111980

Cited by 31 publications

(13 citation statements)

References 83 publications

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“…Photoresponsive nanomaterials have been extensively applied for energy conversion, electronic devices, and medical therapies [1][2][3][4][5][6][7][8]. Recently, the use of light-activated nanomaterials has been focused on phototherapy [9][10][11][12][13][14][15][16]. Phototherapy is defined as the use of photoresponsive nanomaterials to generate heat or noxious components to kill microorganisms or cells [17][18][19].…”

Section: Introductionmentioning

confidence: 99%

Gold Nanorod-Decorated Metallic MoS2 Nanosheets for Synergistic Photothermal and Photodynamic Antibacterial Therapy

et al. 2021

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Light-responsive nanocomposites have become increasingly attractive in the biomedical field for antibacterial applications. Visible-light-activated metallic molybdenum disulfide nanosheets (1T-MoS2 NSs) and plasmonic gold nanorods (AuNRs) with absorption at a wavelength of 808 nm were synthesized. AuNR nanocomposites decorated onto 1T-MoS2 NSs (MoS2@AuNRs) were successfully prepared by electrostatic adsorption for phototherapy applications. Based on the photothermal effect, the solution temperature of the MoS2@AuNR nanocomposites increased from 25 to 66.7 °C after 808 nm near-infrared (NIR) laser irradiation for 10 min. For the photodynamic effect, the MoS2@AuNR nanocomposites generated reactive oxygen species (ROS) under visible light irradiation. Photothermal therapy and photodynamic therapy of MoS2@AuNRs were confirmed against E. coli by agar plate counts. Most importantly, the combination of photothermal therapy and photodynamic therapy from the MoS2@AuNR nanocomposites revealed higher antibacterial activity than photothermal or photodynamic therapy alone. The light-activated MoS2@AuNR nanocomposites exhibited a remarkable synergistic effect of photothermal therapy and photodynamic therapy, which provides an alternative approach to fight bacterial infections.

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Section: Introductionmentioning

confidence: 99%

Gold Nanorod-Decorated Metallic MoS2 Nanosheets for Synergistic Photothermal and Photodynamic Antibacterial Therapy

et al. 2021

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“…Photothermal therapy (PTT) is an emerging approach to treat several diseases using electromagnetic radiation [ 193 ]. A variety of photothermal-based nanomaterials have been synthesized for RA treatment, such as metal NPs, metal oxide NPs, palladium nanosheets, black phosphorus nanosheets and polymeric nanocomposites [ 157 , [159] , [160] , [161] , 194 ] ( Table 4 ).…”

Section: Nanomaterials For Bone-related Disease Therapymentioning

confidence: 99%

Nanomaterial-assisted theranosis of bone diseases

Zheng

Bai

Yang

et al. 2023

Bioactive Materials

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“…Hydrogels are crosslinked polymer networks with a high-water content, and can be fabricated to simulate the physicochemical properties of cartilage tissue [ 14 ]. These approaches provide a new avenue for research in cartilage regeneration [ 15 ].…”

Section: Introductionmentioning

confidence: 99%

Adhesive hydrogels in osteoarthritis: from design to application

et al. 2023

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Osteoarthritis (OA) is the most common type of degenerative joint disease which affects 7% of the global population and more than 500 million people worldwide. One research frontier is the development of hydrogels for OA treatment, which operate either as functional scaffolds of tissue engineering or as delivery vehicles of functional additives. Both approaches address the big challenge: establishing stable integration of such delivery systems or implants. Adhesive hydrogels provide possible solutions to this challenge. However, few studies have described the current advances in using adhesive hydrogel for OA treatment. This review summarizes the commonly used hydrogels with their adhesion mechanisms and components. Additionally, recognizing that OA is a complex disease involving different biological mechanisms, the bioactive therapeutic strategies are also presented. By presenting the adhesive hydrogels in an interdisciplinary way, including both the fields of chemistry and biology, this review will attempt to provide a comprehensive insight for designing novel bioadhesive systems for OA therapy.

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Strontium ranelate-laden near-infrared photothermal-inspired methylcellulose hydrogel for arthritis treatment

Cited by 31 publications

References 83 publications

Gold Nanorod-Decorated Metallic MoS2 Nanosheets for Synergistic Photothermal and Photodynamic Antibacterial Therapy

Gold Nanorod-Decorated Metallic MoS2 Nanosheets for Synergistic Photothermal and Photodynamic Antibacterial Therapy

Nanomaterial-assisted theranosis of bone diseases

Adhesive hydrogels in osteoarthritis: from design to application

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