Strontium ranelate-loaded POFC/β-TCP porous scaffolds for osteoporotic bone repair

Abstract

It is of considerable significance to fabricate scaffolds with satisfactory osteogenic activities and high osteogenesis quality to accelerate osteoporotic repair.

Complexation of Injectable Biphasic Calcium Phosphate with Phosphoserine-Presenting Dendrons with Enhanced Osteoregenerative Properties

“…The integration of Sr presented a positive effect on cell viability of MSCs until day 3 and promoted the early Runx2 osteogenic marker expression. This result was in line with a previous study, which showed that porous Sr-loaded β-TCP-based scaffold could significantly increase the gene expression of Runx2 in the rat bone marrow-derived MSCs on day 4, compared to the nonloaded scaffold . Panzavolta et al also found that Sr-containing HA-based scaffold enhanced osteoblast activity and reduced both the number and differentiation of osteoclast from monocyte precursors .…”

“…This result was in line with a previous study, which showed that porous Sr-loaded β-TCP-based scaffold could significantly increase the gene expression of Runx2 in the rat bone marrow-derived MSCs on day 4, compared to the nonloaded scaffold. 49 Panzavolta et al also found that Sr-containing HA-based scaffold enhanced osteoblast activity and reduced both the number and differentiation of osteoclast from monocyte precursors. 50 It was demonstrated by several preclinical studies that the Sr element could improve the osteoporotic bone strength, bone microarchitecture, and fracture healing by enhancing preosteoblastic proliferation and inhibiting osteoclastic differentiation via extracellular regulated protein kinase (ERK)-related pathways.…”

Effect of Different Additives on the Mechanical Properties of Gelatin Methacryloyl Hydrogel: A Meta-analysis

“…GelMA has been applied in bone tissue engineering. However, the disadvantage of GelMA as a scaffold for bone tissue process is its poor mechanical properties (the compressive modulus of a human trabecular bone is 50–500 18 and 2–12 MPa; 19 the stiffness range of a native spongy bone is 55–480 MPa 20 ), which limits its application. 21 In order to improve the mechanical properties of GelMA, one method is to change the synthetic parameters of the GelMA hydrogel (such as acylation, photocrosslinking conditions, etc.).…”

Core–Shell Nanofibers with a Shish-Kebab Structure Simulating Collagen Fibrils for Bone Tissue Engineering

“…Suitable pore size and porosity of bone tissue engineering scaffold are the key points for osteoconductivity, osteoinductivity, and biocompatibility, which provide a suitable microenvironment for cell growth. , Researchers have adopted many techniques such as solvent casting, selective laser sintering, electrospinning, and 3D printing to manufacture effective bone tissue engineering scaffolds. − Currently, electrospinning technology is considered to be an effective technology for producing nanofibrous membranes that mimic the morphology of the natural extracellular matrix (ECM) of bone tissues. − Collagen molecules are arranged along the helical axis in a staggered configuration to form collagen fibers, which are the main components of bone tissues. − Continuous collagen molecules at both ends are connected to form a periodic structure called D-banding, which provides a three-dimensional environment and enough space for cell growth. , The surface of electrospun nanofibers is smooth and lacks enough three-dimensional space for cell growth . In addition, the micro- or nanoscale topological structure of bone tissue engineering scaffold affects cell adhesion, proliferation, and differentiation .…”

“…7,8 Suitable pore size and porosity of bone tissue engineering scaffold are the key points for osteoconductivity, osteoinductivity, and biocompatibility, which provide a suitable microenvironment for cell growth. 9,10 Researchers have adopted many techniques such as solvent casting, selective laser sintering, electrospinning, and 3D printing to manufacture effective bone tissue engineering scaffolds. 11−14 Currently, electrospinning technology is considered to be an effective technology for producing nanofibrous membranes that mimic the morphology of the natural extracellular matrix (ECM) of bone tissues.…”