Strontium ranelate: long-term efficacy against vertebral, nonvertebral and hip fractures in patients with postmenopausal osteoporosis

Reginster, Jean‐Yves; Hiligsmann, Mickaël; Bruyère, Olivier

doi:10.1177/1759720x10362824

Cited by 5 publications

(4 citation statements)

References 55 publications

(98 reference statements)

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“…Trial evidence suggests that it is effective in a wide range of patient profiles, from early postmenopausal women with osteopenia to elderly women over the age of 80 years, and its antifracture efficacy is independent of baseline severity of osteoporosis, bone turnover level or the presence of clinical risk factors [Reginster et al 2010]. Furthermore, the antifracture efficacy of strontium ranelate is sustained over 8 years ].…”

Section: Dual Mode Of Actionmentioning

confidence: 99%

Aging and bone loss: new insights for the clinician

Demontiero¹,

Vidal²,

Duque³

2011

Therapeutic Advances in Musculoskeletal

434

291

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IntroductionAs a result of the aging process, the bone deteriorates in composition, structure and function, which predisposes to osteoporosis. Osteoporosis is defined as deterioration in bone mass and micro-architecture, with increasing risk to fragility fractures [Raisz and Rodan, 2003]. Owing to the close relationship between the aging process of bone and the pathogenesis of osteoporosis, research on the mechanisms of age-related bone loss has increased significantly in recent years involving a combination of basic, clinical, observational and translational studies.Bone is a dynamic organ that serves mechanical and homeostatic functions. It undergoes a continual self-regeneration process called remodeling. Remodeling removes old bone and replaces it with new bone. This regenerative process occurs in distinct areas of bone known as bone metabolic units (BMUs) [Riggs et al. 2002]. Within each BMU bone formation by osteoblasts and bone resorption by osteoclasts is coupled tightly in a delicate balance to maintain bone mass and strength to resist deformity. With aging this balance shifts in a negative direction, favoring greater bone resorption and less bone formation. This combination of bone mass deficiency and reduction in strength ultimately results in osteoporosis and fractures.Aging in combination with intrinsic and extrinsic factors accelerates the decline in bone mass that predisposes to fractures. Intrinsic factors include genetics, peak bone mass accrual in youth, alterations in cellular components, hormonal, biochemical and vasculature status. Extrinsic factors include nutrition, physical activity, comorbid medical conditions and drugs. In this article we review the mechanisms of age-related bone deterioration and their impact on the pathogenesis of osteoporosis. In addition, current and future therapeutic approaches focused on the correction of mechanisms associated with aging bone will also be outlined. Bone remodeling in aging boneRemodeling is continuous and coordinated cycle of removal of old bone by osteoclasts followed by the deposition of new bone by osteoblasts in response to micro damage and variable mechanical loadings. Bone remodeling is a continuous process throughout life. In the first three decades of life, bone turnover is coupled tightly to maintain a steady state between bone resorption and bone formation. Although there are variances in turnover rates, peak bone mass and size is achieved around the age of 15-20 years in women and later in men [Raisz and Seeman, 2001]. After this, long before sex steroids deficiency occurs, bone loss Aging and bone loss: new insights for the clinicianOddom Demontiero, Christopher Vidal and Gustavo Duque Abstract: It is well known that the underlying mechanisms of osteoporosis in older adults are different than those associated with estrogen deprivation. Age-related bone loss involves a gradual and progressive decline, which is also seen in men. Markedly increased bone resorption leads to the initial fall in bone mineral density. With increasing age, th...

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Section: Dual Mode Of Actionmentioning

confidence: 99%

Aging and bone loss: new insights for the clinician

Demontiero¹,

Vidal²,

Duque³

2011

Therapeutic Advances in Musculoskeletal

434

291

View full text Add to dashboard Cite

show abstract

“…One of the most studied salts is strontium ranelate (SrR), a drug used, in particular, in the treatment of postmenopausal osteoporosis. Its effectiveness lies in its dual action, including increasing bone formation and inhibiting bone resorption [15]. These effects have been confirmed by many studies, both on animal models as well as in clinical trials conducted with the participation of humans [16][17][18].…”

Section: Discussionmentioning

confidence: 81%

“…Research conducted by Wronski et al [52] showed that more than 150 days after the OVX procedure, osteoblast surfaces and osteoclast surfaces in ovariectomized rats decreased to the levels of cells taken from the sham ovariectomy group. As well, micro-CT studies have shown that the most intense changes in bone tissue after OVX treatment occur between 8 and 16 weeks after surgery [15,18,52].…”

Section: Discussionmentioning

confidence: 98%

Influence of Various Strontium Formulations (Ranelate, Citrate, and Chloride) on Bone Mineral Density, Morphology, and Microarchitecture: A Comparative Study in an Ovariectomized Female Mouse Model of Osteoporosis

Tomczyk-Warunek,

Turżańska,

Posturzyńska

et al. 2024

IJMS

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Osteoporosis stands out as a prevalent skeletal ailment, prompting exploration into potential treatments, including dietary strontium ion supplements. This study assessed the efficacy of supplementation of three strontium forms—strontium citrate (SrC), strontium ranelate (SrR), and strontium chloride (SrCl)—for enhancing bone structure in 50 female SWISS mice, aged seven weeks. In total, 40 mice underwent ovariectomy, while 10 underwent sham ovariectomy. Ovariectomized (OVX) mice were randomly assigned to the following groups: OVX (no supplementation), OVX + SrR, OVX + SrC, and OVX + SrCl, at concentrations equivalent to the molar amount of strontium. After 16 weeks, micro-CT examined trabeculae and cortical bones, and whole-bone strontium content was determined. Results confirm strontium administration increased bone tissue mineral density (TMD) and Sr content, with SrC exhibiting the weakest effect. Femur morphometry showed limited Sr impact, especially in the OVX + SrC group. This research highlights strontium’s potential in bone health, emphasizing variations in efficacy among its forms.

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“…Both oral and in vitro studies confirm that Sr can pharmacologically increase bone formation and decrease bone resorption at the cellular level ( Reginster et al, 2010 ; Reginster et al, 2013 ) and Sr compounds can activate osteoblast and osteoclast activity through different signaling pathways ( Saidak and Marie, 2012 ). Li studies proved that Sr can promote osteogenic differentiation of stem cells, and up regulation of several osteogenic genes as well as an increase in ALP protein expression was observed when rat mesenchymal stem cell (MSCs) were cultured in Sr supplemented medium ( Li et al, 2012 ).…”

Section: Introductionmentioning

confidence: 91%

Regulation of Magnesium Matrix Composites Materials on Bone Immune Microenvironment and Osteogenic Mechanism

Nie

Zhang

Lei

et al. 2022

Front. Bioeng. Biotechnol.

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Despite magnesium based metal materials are widely used in bone defect repair, there are still various deficiencies, and their properties need to be optimized. Composites synthesized with magnesium based metal as matrix are the research hotspot, and the host immune response after biomaterial implantation is very important for bone binding. By studying the immunoregulation of bone biomaterials, it can regulate the immune response in the process of osteogenesis and create a good local immune microenvironment, which is conducive to biomaterials to reduce inflammatory response and promote good bone binding. This article introduces the osteogenic mechanism of magnesium based metal materials and its regulation on bone immune microenvironment in detail.

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Strontium ranelate: long-term efficacy against vertebral, nonvertebral and hip fractures in patients with postmenopausal osteoporosis

Cited by 5 publications

References 55 publications

Aging and bone loss: new insights for the clinician

Aging and bone loss: new insights for the clinician

Influence of Various Strontium Formulations (Ranelate, Citrate, and Chloride) on Bone Mineral Density, Morphology, and Microarchitecture: A Comparative Study in an Ovariectomized Female Mouse Model of Osteoporosis

Regulation of Magnesium Matrix Composites Materials on Bone Immune Microenvironment and Osteogenic Mechanism

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