Strontium regulates stem cell fate during osteogenic differentiation through asymmetric cell division

Li, Yanqun; Yue, Jianhui; Liu, Yuan; Wu, Jun; Guan, Min; Chen, Di; Pan, Haobo; Zhao, Xiaoli; Lu, William W.

doi:10.1016/j.actbio.2020.10.030

Cited by 27 publications

(18 citation statements)

References 61 publications

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“…Not only this, but Sr also promotes the proliferation of MSCs and maintains the cell population for osteogenic differentiation. Li et al [ 38 ] found that Sr maintained more cell numbers in the cell cycle by raising the population of S and G2/M phase cells in initiating osteogenic differentiation, and the increased number of cells contributed to enhanced osteogenic differentiation. Cheng et al [ 39 ] demonstrated that Sr-containing scaffolds were able to induce the osteogenic differentiation of MSCs.…”

Section: Mechanisms Of Sr On Bone Regenerationmentioning

confidence: 99%

Recent Advance of Strontium Functionalized in Biomaterials for Bone Regeneration

et al. 2023

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Bone defect disease causes damage to people’s lives and property, and how to effectively promote bone regeneration is still a big clinical challenge. Most of the current repair methods focus on filling the defects, which has a poor effect on bone regeneration. Therefore, how to effectively promote bone regeneration while repairing the defects at the same time has become a challenge for clinicians and researchers. Strontium (Sr) is a trace element required by the human body, which mainly exists in human bones. Due to its unique dual properties of promoting the proliferation and differentiation of osteoblasts and inhibiting osteoclast activity, it has attracted extensive research on bone defect repair in recent years. With the deep development of research, the mechanisms of Sr in the process of bone regeneration in the human body have been clarified, and the effects of Sr on osteoblasts, osteoclasts, mesenchymal stem cells (MSCs), and the inflammatory microenvironment in the process of bone regeneration have been widely recognized. Based on the development of technology such as bioengineering, it is possible that Sr can be better loaded onto biomaterials. Even though the clinical application of Sr is currently limited and relevant clinical research still needs to be developed, Sr-composited bone tissue engineering biomaterials have achieved satisfactory results in vitro and in vivo studies. The Sr compound together with biomaterials to promote bone regeneration will be a development direction in the future. This review will present a brief overview of the relevant mechanisms of Sr in the process of bone regeneration and the related latest studies of Sr combined with biomaterials. The aim of this paper is to highlight the potential prospects of Sr functionalized in biomaterials.

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Section: Mechanisms Of Sr On Bone Regenerationmentioning

confidence: 99%

Recent Advance of Strontium Functionalized in Biomaterials for Bone Regeneration

et al. 2023

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“…Stem cells can undergo osteogenic differentiation to maintain bone homeostasis and regeneration. , The ability of particles to further induce stem cell differentiation to osteoblasts was evaluated by performing ALP and ARS staining after coculturing particles with stem cells under D-BM and D-CM conditions.…”

Section: Resultsmentioning

confidence: 99%

Cascade Regulation of the Proliferation, Recruitment, and Differentiation of Stem Cells to Prevent Aseptic Loosening by GNPs/ECPP Particles Responding to Macrophages: In Vitro and In Vivo

Lei

et al. 2023

ACS Biomater. Sci. Eng.

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Modulating both inflammation and stem cells by designing an artificial joint material to obtain the continuous prevention and control on aseptic loosening (AL) is a novel strategy. In this paper, graphene/europium-doped calcium polyphosphate (GNPs/ECPP) particles were obtained by ultrasound method and spark plasma sintering (SPS) method. The prepared particles were used to modulate the inflammatory response and further obtain cascade regulation on the proliferation, recruitment, and differentiation of stem cells. The results showed that particles obtained by SPS had a stronger effect on promoting the proliferation and differentiation of stem cells, while by ultrasound method more stem cells were recruited. Besides, the graphene and Eu3+ contained in the particles obtained by SPS method could effectively play a synergistic role on the differentiation of stem cells. In vivo experiment results demonstrated that the composite particles effectively suppress the inflammatory response, recruit stem cells, and prevent AL by inhibiting the secretion of inflammatory factors.

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“…In our study osteogenesis increased by increasing Cs/Alg/Sr‐MSN concentration in prepared scaffolds, but surprisingly the amount of osteogenic differentiation of Cs/Alg/Sr‐MSN30 scaffolds was lower than in Sr‐MSN20‐containing scaffolds. In this regard, it has been shown that an optimized amount of strontium can significantly improve stem cell proliferation and differentiation but a large amount of strontium will cause harm to cells 44,45 …”

Section: Resultsmentioning

confidence: 99%

Strontium‐doped mesoporous silica nanoparticles incorporated in chitosan/alginate biocomposite scaffolds for enhanced bone tissue regeneration

Yousefiasl

Manoochehri

Sharifi

2023

Polymers for Advanced Techs

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Critical-sized bone damage resulting from traumas, fractures, and tumors, impairs the bone tissues' inherent capacity for self-repair. Conventional therapies could be associated with infection and pain besides demanding additional surgery while being costly. These limitations highlight the paucity of potential unique treatment strategies such as bone tissue engineering. In this study, strontium-doped mesoporous silica nanoparticles (Sr-MSN) were successfully synthesized and incorporated into the chitosan/alginate scaffolds which were then freeze-dried and cross-linked using CaCl 2 .The physicochemical characteristics of the fabricated scaffolds containing various Sr-MSN contents were investigated using Fourier-transform infrared spectroscopy (FTIR), Scanning Electron Microscopy (SEM), and Energy Dispersive Spectroscopy (EDS). The hydrolytic degradation of the scaffolds was decreased with the increase in the Sr-MSN content while maintaining their water uptake capacity. All fabricated scaffolds showed biocompatibility and Sr-MSN-containing scaffolds showed significantly increased Bone marrow mesenchymal stem cells (BMSCs) cell viability compared to chitosan/alginate scaffold after 72 h. The osteogenic differentiation potential investigations via mineralization assay and alkaline phosphatase enzyme activity indicated that the chitosan/alginate scaffold containing 20% Sr-MSN showed the highest osteogenic differentiation capacity. Overall, bionanocomposite Cs/Alg/ Sr-MSN scaffolds integrated with desired physicochemical characteristics, biocompatibility, osteogenic differentiation capacity, and drug delivery potential show promising properties for attaining ideal results for bone repair and regeneration applications.

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Strontium regulates stem cell fate during osteogenic differentiation through asymmetric cell division

Cited by 27 publications

References 61 publications

Recent Advance of Strontium Functionalized in Biomaterials for Bone Regeneration

Recent Advance of Strontium Functionalized in Biomaterials for Bone Regeneration

Cascade Regulation of the Proliferation, Recruitment, and Differentiation of Stem Cells to Prevent Aseptic Loosening by GNPs/ECPP Particles Responding to Macrophages: In Vitro and In Vivo

Strontium‐doped mesoporous silica nanoparticles incorporated in chitosan/alginate biocomposite scaffolds for enhanced bone tissue regeneration

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