Structural abnormalities in benign childhood epilepsy with centrotemporal spikes (BCECTS)

Kim, Eun‐Hee; Yum, Mi‐Sun; Shim, Woo-Hyun; Yoon, Hye-Kyung; Lee, Yun-Jeong; Ko, Tae‐Sung

doi:10.1016/j.seizure.2015.02.027

Cited by 41 publications

(50 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Among the basal ganglia structures, putamen was selectively hypertrophied in BECTS . A recent study using FreeSurfer to examine cortical and subcortical structures in newly diagnosed BECTS also reported selective putamen hypertrophy . Given the growing evidence for putamen anomaly in newly BECTS and in an effort to reduce the number of comparisons, we elected to focus on putamen and examine its prospective change in this study.…”

Section: Discussionmentioning

confidence: 99%

Cognition and brain development in children with benign epilepsy with centrotemporal spikes

et al. 2015

View full text Add to dashboard Cite

Objective Benign epilepsy with centrotemporal spikes (BECTS), the most common focal childhood epilepsy, is associated with subtle abnormalities in cognition and possible developmental alterations in brain structure when compared to healthy participants as indicated by previous cross-sectional studies. To examine the natural history of BECTS, we investigated cognition, cortical thickness, and subcortical volumes in children with new/recent onset BECTS and healthy controls (HC). Methods Participants were 8–15 years of age, including 24 children with new onset BECTS and 41 age- and gender-matched HC. At baseline and two years later, all participants completed a cognitive assessment and a subset (13 BECTS, 24 HC) underwent T1 volumetric MRI scans focusing on cortical thickness and subcortical volumes. Results Baseline cognitive abnormalities associated with BECTS (object naming, verbal learning, arithmetic computation, psychomotor speed/dexterity) persisted over two years, with the rate of cognitive development paralleling that of HC. Baseline neuroimaging revealed thinner cortex in BECTS compared to controls in frontal, temporal, and occipital regions. Longitudinally, HC showed widespread cortical thinning in both hemispheres, while BECTS participants showed sparse regions of both cortical thinning and thickening. Analyses of subcortical volumes showed larger left and right putamens persisting over two years in BECTS compared to HC. Significance Cognitive and structural brain abnormalities associated with BECTS are present at onset and persist (cognition) and/or evolve (brain structure) over time. Atypical maturation of cortical thickness antecedent to BECTS onset results in early-identified abnormalities that further continue to abnormally develop over time. However, cognition appears more resistant to further change over time compared to anatomical development.

show abstract

Section: Discussionmentioning

confidence: 99%

Cognition and brain development in children with benign epilepsy with centrotemporal spikes

et al. 2015

View full text Add to dashboard Cite

show abstract

“…13,14 Similarly, although interest has been longstanding in regard to the complications of language-based abilities in children with BECTS, [15][16][17] cognitive complications of BECTS have been reported in diverse areas of mentation compared to age-matched control peers, 8,15,18,19 including not only language-related skills but intelligence, memory, attention, and executive function (for reviews, see Wickens et al, 5,20 Pal et al 20 ). Importantly, cognitive and magnetic resonance (MR) abnormalities have been reported in new onset cases as well, with the nature and range of anomalies varying across studies, [21][22][23][24] attesting that these abnormalities are not necessarily secondary to the effects of epilepsy chronicity and medication treatment. 19 Prospective cognitive and imaging research in BECTS is much less common.…”

Section: Introductionmentioning

confidence: 99%

Network analysis of prospective brain development in youth with benign epilepsy with centrotemporal spikes and its relationship to cognition

et al. 2019

View full text Add to dashboard Cite

Objective Benign epilepsy with centrotemporal spikes (BECTS) is the most common childhood idiopathic localization‐related epilepsy syndrome. BECTS presents normal routine magnetic resonance imaging (MRI); however, quantitative analytic techniques have captured subtle cortical and subcortical magnetic resonance anomalies. Network science, including graph theory (GT) analyses, facilitates understanding of brain covariance patterns, potentially informing in important ways how this common self‐limiting epilepsy syndrome may impact normal patterns of brain and cognitive development. Methods GT analyses examined the developmental covariance among cortical and subcortical regions in children with new/recent onset BECTS (n = 19) and typically developing healthy controls (n = 22) who underwent high‐resolution MRI and cognitive assessment at baseline and 2 years later. Global (transitivity, global efficiency, and modularity index [Q]) and regional measures (local efficiency and hubs) were investigated to characterize network development in each group. Associations between baseline‐based GT measures and cognition at both time points addressed the implications of GT analyses for cognition and prospective cognitive development. Furthermore, an individual contribution measure was investigated, reflecting how important for cognition it is for BECTS to resemble the correlation matrices of controls. Results Groups exhibited similar Q and overall network configuration, with BECTS presenting significantly higher transitivity and both global and local efficiency. Furthermore, both groups presented a similar number of hubs, with BECTS showing a higher number in temporal lobe regions compared to controls. The investigated measures were negatively associated with 2‐year cognitive outcomes in BECTS. Significance Children with BECTS present a higher‐than‐normal global developmental configuration compared to controls, along with divergence from normality in terms of regional configuration. Baseline GT measures demonstrate potential as a cognitive biomarker to predict cognitive outcome in BECTS 2 years after diagnosis. Similarities and differences in developmental network configurations and their implications for cognition and behavior across common epilepsy syndromes are of theoretical interest and clinical relevance.

show abstract

“…The insular cortex is known to be involved in processing of emotional faces, mostly fear and disgust, whereas the dorsal striatum plays an important role in how individuals perceive fearful faces and in the processing of salient stimuli . This is particularly interesting, as recent morphometric studies showed delayed thickening of the insular cortex and striatal hypertrophy in BCECTS, suggestive of abnormal maturation of these structures.…”

Section: Discussionmentioning

confidence: 99%

Behavioral and fMRI responses to fearful faces are altered in benign childhood epilepsy with centrotemporal spikes (BCECTS)

et al. 2017

View full text Add to dashboard Cite

show abstract

Structural abnormalities in benign childhood epilepsy with centrotemporal spikes (BCECTS)

Cited by 41 publications

References 39 publications

Cognition and brain development in children with benign epilepsy with centrotemporal spikes

Cognition and brain development in children with benign epilepsy with centrotemporal spikes

Network analysis of prospective brain development in youth with benign epilepsy with centrotemporal spikes and its relationship to cognition

Behavioral and fMRI responses to fearful faces are altered in benign childhood epilepsy with centrotemporal spikes (BCECTS)

Contact Info

Product

Resources

About