Structural Alterations of Mucosal Microvascular System in Human Chronic Gastritis

Tsuchihashi, Yasunari; Tani, Toshio; Maruyama, Kyohei; Yorioka, S; Okada, Konosuke; Sudo, Hiromasa; Ashihara, Tsukasa; Fujita, Setsuya; Kawai, Keiichi

doi:10.1007/978-4-431-68078-9_17

Cited by 16 publications

(19 citation statements)

References 4 publications

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“…4 In this study, 96.2% (381/396) of RAC-negative patients had H. pylori-induced gastritis and 93.8% (151/161) of RACpositive patients had normal stomachs without H. pylori infection.This result indicates that the presence of RAC was a significant finding in the H. pylori-negative normal stomach. 10 In our study, we found one cardiac cancer (mucosal type) and three adenocarcinomas in shortsegment Barrett's esophagus (one mucosal and two submucosal cancer).The stomachs in all four cases were diagnosed as RAC positive during endoscopic examination.…”

Section: Discussionsupporting

confidence: 46%

“…(see Fig. 10 Histologically, the width of pits and epithelia forming pits measured 60 mm with a micrometer. 4 In this study, 96.2% (381/396) of RAC-negative patients had H. pylori-induced gastritis and 93.8% (151/161) of RACpositive patients had normal stomachs without H. pylori infection.This result indicates that the presence of RAC was a significant finding in the H. pylori-negative normal stomach.…”

Section: Discussionmentioning

confidence: 99%

“…The appearances of the wDRP and Z-0 in the antrum and corpus of the H. pylori-negative normal stomach differ because the mucosal microvascular system, which includes the collecting venules, is not as well developed in the antrum as in the corpus, 10 and the structures of the surface mucosal epithelia are different. However, 39% (25/64) of patients with H. pylori-induced gastritis had wDRP.This result means that iDRP is a characteristic finding in H. pyloriinduced gastritis, whereas wDRP is not unique to the H. pylori-negative normal stomach.…”

mentioning

confidence: 97%

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Characteristic endoscopic and magnified endoscopic findings in the normal stomach without Helicobacter pylori infection

Yagi

Nakamura

Sekine

2002

J of Gastro and Hepatol

177

206

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Section: Discussionsupporting

confidence: 46%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 97%

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Characteristic endoscopic and magnified endoscopic findings in the normal stomach without Helicobacter pylori infection

Yagi

Nakamura

Sekine

2002

J of Gastro and Hepatol

177

206

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“…The loop-like pattern we observed coincides with that reported by Tsuchihashi et al (1988), who employed an Indian inkinjection method. Unlike their method, ours does not require fresh tissues and could be applied to the study of the microvasculature of tissues using the standard paraffin blocks prepared for pathological diagnosis.…”

Section: Discussionsupporting

confidence: 93%

Histochemical, ultrastructural, and three-dimensional observation of smooth muscle cells in human gastric mucosa

Arai

Ota

Hidaka

et al. 2004

Histochemistry and Cell Biology

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The present study was undertaken to clarify the histochemical and ultrastructural properties and the three-dimensional distribution of the smooth muscle cells (SMCs) located in the lamina propria (LP) of the human gastric mucosa. Standard paraffin sections obtained from stomachs surgically resected for gastric cancer were immunostained for alpha-smooth muscle actin (alpha-SMA), vimentin, desmin, laminin, and type IV collagen. In addition, 100-microm-thick sections were fluorostained for alpha-SMA and CD34, while three-dimensional images were prepared by confocal laser scanning microscope. Ultrastructural studies were carried out using normal gastric biopsy specimens. The results indicated that SMCs in the LP differed between the upper and lower regions, SMCs in the lower LP being fairly typical SMCs, whereas those in the upper LP had apparently lost reactivity for desmin but gained that for vimentin. The basal lamina became sparser, but a fibronexus was occasionally seen in SMCs in the upper LP. Three-dimensional images revealed bundles of SMCs in the upper LP encircling several foveolae to form acinus-like structures and, in the upper LP, SMCs branching into fine fibrils with a brush-like (corpus) or besom-like (i.e., a twiggy "witch's broom") appearance (antrum).

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“…True capillaries surround each of the glands and connect to the collecting venules. 13 The interval between collecting venules was estimated to be about 350 µm, as measured on an endoscopic monitor.…”

Section: Magnified Views Of Rac and Histological Findingsmentioning

confidence: 99%

Regular arrangement of collecting venules (RAC): a characteristic endoscopic feature of Helicobacter pylori-negative normal stomach and its relationship with esophago-gastric adenocarcinoma

et al. 2005

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found that if collecting venules were visible as numerous minute points, regularly distributed over the entire gastric body, the patients had a normal stomach and no H. pylori infection. 8,9,11 We termed this finding "regular arrangement of collecting venules (RAC)." Further characterization using magnified views showed RAC to consist of collecting venules, a network of true capillaries, and gastric pits with a pinhole-like appearance. [8][9][10][11] Patients in whom RAC was not observed endoscopically (RAC-negative) had H. pylori infection. Compared to culturing and histological diagnosis, the accuracy of RAC in identifying H. pylori infection was 95%. From 1998 onwards, we began using RAC as a diagnostic method, and subsequently we studied the incidence of adenocarcinomas arising in patients with and without H. pylori infection. The RAC method is very practical, given that almost all chronic gastritis is induced by H. pylori and that this bacterium is involved in various disease states. Regular arrangement of collecting venules (RAC): a characteristic endoscopic feature of the H. pylorinegative normal stomachOn conventional endoscopy, H. pylori-negative normal stomach shows numerous minute points throughout the gastric body (Fig. 1), and it is not unusual to observe these minute points near the pyloric ring, especially in young patients. This endoscopic finding was termed "regular arrangement of collecting venules (RAC)," because the minute points were revealed to be collecting venules. 8-11 On closer observation, the points were shown to be star-fish like arrangements of vessels. Patients in whom RAC is observed endoscopically are termed 9,11 In patients with duodenal ulcer, or young patients with H. pylori infection, minute points are often observed in the middle body or upper gastric body, because the infection does not always ex-

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Structural Alterations of Mucosal Microvascular System in Human Chronic Gastritis

Cited by 16 publications

References 4 publications

Characteristic endoscopic and magnified endoscopic findings in the normal stomach without Helicobacter pylori infection

Characteristic endoscopic and magnified endoscopic findings in the normal stomach without Helicobacter pylori infection

Histochemical, ultrastructural, and three-dimensional observation of smooth muscle cells in human gastric mucosa

Regular arrangement of collecting venules (RAC): a characteristic endoscopic feature of Helicobacter pylori-negative normal stomach and its relationship with esophago-gastric adenocarcinoma

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