2007
DOI: 10.1016/j.amjhyper.2007.03.016
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Structural Alterations of Subcutaneous Small-Resistance Arteries May Predict Major Cardiovascular Events in Patients With Hypertension

Abstract: Structural alterations of small-resistance arteries may predict FCE and SMI. The prognostic role of small-resistance artery structure also applies to medium-risk patients with essential hypertension, at least when MCEs are included in the analysis.

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Cited by 132 publications
(76 citation statements)
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“…Skin circulation also is altered in a number of disease states, including renal disease (2), hypercholesterolemia (3), peripheral vascular disease (4), heart failure, and hypertension (5). Identification of structural alterations to the subcutaneous microvasculature provides a powerful prognostic tool to predict cardiovascular events in hypertensive patients (6), and impaired microvascular vasodilation and capillary rarefaction is associated with familial predisposition to hypertension (7).…”
Section: Hif-alpha | Arginase | Vascular Tonementioning
confidence: 99%
“…Skin circulation also is altered in a number of disease states, including renal disease (2), hypercholesterolemia (3), peripheral vascular disease (4), heart failure, and hypertension (5). Identification of structural alterations to the subcutaneous microvasculature provides a powerful prognostic tool to predict cardiovascular events in hypertensive patients (6), and impaired microvascular vasodilation and capillary rarefaction is associated with familial predisposition to hypertension (7).…”
Section: Hif-alpha | Arginase | Vascular Tonementioning
confidence: 99%
“…This parameter is widely used in resistance-sized arteries structural analysis and its increment has been related to an increased risk of cardiovascular disease in hypertensive patients [20][21].…”
Section: Discussionmentioning
confidence: 99%
“…Hypoxia, in turn, is a condition that activates angiogenic genes, such as HIF, which further stimulate the formation of new vessels [20].…”
Section: Discussionmentioning
confidence: 99%
“…There are now numerous studies which support the notion that changes in small artery structure have strong prognostic significance in hypertensive patients, over and above all other known cardiovascular risk factors (Rizzoni et al, 2003;De Ciuceis et al, 2007;Mathiassen, Buus, et al, 2007b). Understanding the mechanisms which may modulate resistance arterial eutrophic remodelling is thus important, but these remain poorly understood.…”
Section: Resistance Artery Structure and Hypertensionmentioning
confidence: 99%