Structural analysis and simulation of solid microneedle array for vaccine delivery applications

J, Chandbadshah S B V; Mannayee, Giriraj

doi:10.1016/j.matpr.2022.06.483

Cited by 12 publications

(5 citation statements)

References 18 publications

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“…Hence, the Von Mises stress failure criterion is adopted in this work. Because the hyper-elastic models in Abaqus/Explicit do not incorporate the material failure mechanism, a special user material subroutine with a Von Mises stress failure criterion is put forward [ 57 ]. When the effective stress of the unit near the MN tip meets the failure criteria shown in (2) , the unit will be identified and removed from the grid [ 46 , 58 ].…”

Section: Methodsmentioning

confidence: 99%

A flexible and dissolving traditional Chinese medicine microneedle patch for sleep-aid intervention

He,

Fang,

et al. 2024

Heliyon

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Section: Methodsmentioning

confidence: 99%

A flexible and dissolving traditional Chinese medicine microneedle patch for sleep-aid intervention

He,

Fang,

et al. 2024

Heliyon

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“…Generally, the filling mould methods mainly include centrifugation or vacuum [ 126 ]. Lithography, as a print process, transfers the master pattern of the MNs geometry to the surface of the substrate without any moulds [ 127 ]. The novel technique could use 3D printing and centrifugal lithography [ 125 , 128 ].…”

Section: Challenges In Scale Manufacture and Regulations Of Polymeric...mentioning

confidence: 99%

Recent progress of polymeric microneedle-assisted long-acting transdermal drug delivery

Meng,

Qiao,

Xin

et al. 2024

J. pharm. pharm. sci.

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Microneedle (MN)-assisted drug delivery technology has gained increasing attention over the past two decades. Its advantages of self-management and being minimally invasive could allow this technology to be an alternative to hypodermic needles. MNs can penetrate the stratum corneum and deliver active ingredients to the body through the dermal tissue in a controlled and sustained release. Long-acting polymeric MNs can reduce administration frequency to improve patient compliance and therapeutic outcomes, especially in the management of chronic diseases. In addition, long-acting MNs could avoid gastrointestinal reactions and reduce side effects, which has potential value for clinical application. In this paper, advances in design strategies and applications of long-acting polymeric MNs are reviewed. We also discuss the challenges in scale manufacture and regulations of polymeric MN systems. These two aspects will accelerate the effective clinical translation of MN products.

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“…A micron-scale needle, also known as a microneedle (MN), 1,2 is a minimally invasive needle used for injection, 3,4 dermal and transdermal delivery of drugs, 5−8 biological substances, 9 skin care therapy, 10,11 and monitoring glucose levels 10 through extraction of a special fluid known as interstitial fluid (ISF). 5,12 MNs have been a substitute of hypodermic needles due to their rapid painless procedure, 11,13−15 affordable fabrication methods, 9 reduced tissue rupturing, and self-handle and compact administration. 11 Their capabilities of penetrating the skin layer with the goal of transferring proteins, 9 DNA, 9,14 and vaccines 9,14,16,17 in the most efficient and minimally invasive manner make MNs a promising technology for various medical applications.…”

Section: ■ Introductionmentioning

confidence: 99%

“…5,12 MNs have been a substitute of hypodermic needles due to their rapid painless procedure, 11,13−15 affordable fabrication methods, 9 reduced tissue rupturing, and self-handle and compact administration. 11 Their capabilities of penetrating the skin layer with the goal of transferring proteins, 9 DNA, 9,14 and vaccines 9,14,16,17 in the most efficient and minimally invasive manner make MNs a promising technology for various medical applications. 11,18,19 Moreover, researchers show that MNs can be incorporated with diagnostic capabilities to assess diseases based on painless experience and monitoring the health condition by means of invasive and noninvasive methods.…”

Section: ■ Introductionmentioning

confidence: 99%

Optimizing Solid Microneedle Design: A Comprehensive ML-Augmented DOE Approach

Abdullah,

Ahmadinejad,

Tasoglu

2024

ACS Meas. Sci. Au

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Microneedles (MNs), that is, a matrix of micrometer-scale needles, have diverse applications in drug delivery, skincare therapy, and health monitoring. MNs offer a minimally invasive alternative to hypodermic needles, characterized by rapid and painless procedures, cost-effective fabrication methods, and reduced tissue damage. This study explores four MN designs, cone-shaped, tapered cone-shaped, pyramidal with a square base, and pyramidal with a triangular-shaped base, and their optimization based on predefined criteria. The workflow encompasses three loading conditions: compressive load during insertion, critical buckling load, and bending loading resulting from incorrect insertion. Geometric parameters such as base radius/width, tip radius/width, height, and tapered angle tip influence the output criteria, namely, total deformation, critical buckling loads, factor of safety (FOS), and bending stress. The comprehensive framework employing a design of experiment approach within the ANSYS workbench toolbox establishes a mathematical model and a response surface fitting model. The resulting regression model, sensitivity chart, and response curve are used to create a multiobjective optimization problem that helps achieve an optimized MN geometrical design across the introduced four shapes, integrating machine learning (ML) techniques. This study contributes valuable insights into a potential ML-augmented optimization framework for MNs via needle designs to stay durable for various physiologically relevant conditions.

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Structural analysis and simulation of solid microneedle array for vaccine delivery applications

Cited by 12 publications

References 18 publications

A flexible and dissolving traditional Chinese medicine microneedle patch for sleep-aid intervention

A flexible and dissolving traditional Chinese medicine microneedle patch for sleep-aid intervention

Recent progress of polymeric microneedle-assisted long-acting transdermal drug delivery

Optimizing Solid Microneedle Design: A Comprehensive ML-Augmented DOE Approach

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