Structural analysis of point mutations in the Hairless gene and their association with the activity of the Hairless protein

Paz-Gómez, Daniel; Baizabal-Aguirre, Víctor M.; Valdéz-Alarcón, Juan José; Cajero-Juárez, Marcos; Nagel, Anja C.; Preiss, Anette; Maier, Dieter; Bravo-Patiño, Alejandro

doi:10.1016/j.ijbiomac.2008.08.012

Cited by 2 publications

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“…For example single mutations of both N ( N −/+) or H ( H −/+) show a dominant loss of function phenotype in the adult wings and bristles (mechanosensory organs of the peripheral nervous system). However, in double mutants ( N −/+; H −/+) the wings are almost wild type [ 22 , 32 , 34 , 35 ]. In other words, H functions in a dose dependent manner, reflecting the strategic role of this protein in the NSP [ 22 ], with the peculiarity that, until now, H protein has been identified only in insects [ 33 , 36 ].…”

Section: Introductionmentioning

confidence: 99%

The CSL proteins, versatile transcription factors and context dependent corepressors of the notch signaling pathway

et al. 2016

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The Notch signaling pathway is a reiteratively used cell to cell communication pathway that triggers pleiotropic effects. The correct regulation of the pathway permits the efficient regulation of genes involved in cell fate decision throughout development. This activity relies notably on the CSL proteins, (an acronym for CBF-1/RBPJ-κ in Homo sapiens/Mus musculus respectively, Suppressor of Hairless in Drosophila melanogaster, Lag-1 in Caenorhabditis elegans) which is the unique transcription factor and DNA binding protein involved in this pathway. The CSL proteins have the capacity to recruit activation or repression complexes according to the cellular context. The aim of this review is to describe the different co-repressor proteins that interact directly with CSL proteins to form repression complexes thereby regulating the Notch signaling pathway in animal cells to give insights into the paralogous evolution of these co-repressors in higher eumetazoans and their subsequent effects at developmental processes.

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Section: Introductionmentioning

confidence: 99%

The CSL proteins, versatile transcription factors and context dependent corepressors of the notch signaling pathway

et al. 2016

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The Notch Signaling Pathway and Breast Cancer: The Importance of Balance and Cellular Self-Control

Baizabal-Aguirre¹,

Shen²,

Deshmukh³

et al. 2021

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Notch is a cell-signaling pathway that is highly conserved in all metazoans and is responsible for cell differentiation and cross-talk communication with other signaling pathways such as WNT and Hh. In most cancers, the Notch signaling pathway is altered, causing atypical activity of vital processes such as cell cycle, differentiation and apoptosis, leading the cell to a carcinogenic state. Currently, the Notch signaling pathway has taken a special interest to design strategies in order to regulate the activity of this pathway since it is known that in the cancer molecular micro-environment the Notch pathway is over-expressed or presents an aberrant function, which, in consequence, corrupts the cross-talk communication with WNT and Hh pathways. Most of the existing strategies are focused on the systematic and whole inhibition of Notch pathway at the membrane level by the use of γ-secretases inhibitors. There are few strategies that act at the nuclear level inhibiting the activity of the transcriptional activation complex composed by the Notch intracellular domain, the transcriptional factor CSL and the Mastermind co-activator. In this review, by the fact that there are not any strategy focused to revert the over expression effect caused by the Notch pathway constitutive activity, we propose that the efforts to develop new strategies against cancer should be focused to understand the complexity of the cross-talk communication between Notch, WNT and Hh pathways to neutralize the gene aberrant activity characteristic of cancer cells which are responsible for those corrupted cross-talk communication.

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Structural analysis of point mutations in the Hairless gene and their association with the activity of the Hairless protein

Cited by 2 publications

References 31 publications

The CSL proteins, versatile transcription factors and context dependent corepressors of the notch signaling pathway

The CSL proteins, versatile transcription factors and context dependent corepressors of the notch signaling pathway

The Notch Signaling Pathway and Breast Cancer: The Importance of Balance and Cellular Self-Control

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