2000
DOI: 10.1016/s0378-1119(99)00477-1
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Structural analysis of the gene encoding RP58, a sequence-specific transrepressor associated with heterochromatin

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Cited by 15 publications
(13 citation statements)
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“…Repressor protein 58 (RP58) and insulinomaassociated 1 (Insm1) are zinc-finger proteins that are upregulated due to Notch signaling inhibition (Fig 11). RP58 is a DNA-binding protein that mediates sequence-specific transcriptional repression from E-box motifs, is associated with heterochromatin, and recruits a corepressor complex with Dnmt3a methylase and HDAC1 histone deacetylase (Aoki et al, 1998;Meng et al, 2000;Fuks et al, 2001). Insm1 is a transcription factor necessary for endocrine cell differentiation in the pancreas (Gierl et al, 2006), and is regulated by NeuroD1 and Ngn3 (Breslin et al, 2003;Mellitzer et al, 2006); its function during retinal development is not known.…”
Section: Synchronized Notch Signaling Inactivation Reveals New Componmentioning
confidence: 99%
“…Repressor protein 58 (RP58) and insulinomaassociated 1 (Insm1) are zinc-finger proteins that are upregulated due to Notch signaling inhibition (Fig 11). RP58 is a DNA-binding protein that mediates sequence-specific transcriptional repression from E-box motifs, is associated with heterochromatin, and recruits a corepressor complex with Dnmt3a methylase and HDAC1 histone deacetylase (Aoki et al, 1998;Meng et al, 2000;Fuks et al, 2001). Insm1 is a transcription factor necessary for endocrine cell differentiation in the pancreas (Gierl et al, 2006), and is regulated by NeuroD1 and Ngn3 (Breslin et al, 2003;Mellitzer et al, 2006); its function during retinal development is not known.…”
Section: Synchronized Notch Signaling Inactivation Reveals New Componmentioning
confidence: 99%
“…It contains a Pox virus and zinc finger (POZ) domain that functions as a sequence-specific DNA-binding transcriptional repressor. 24,33,34 No animal models have been reported. A single highly conserved noncoding sequence, designated "UC.43," is located in intron 1 of AKT3 but may regulate ZNF238 expression, since such noncoding sequences are preferentially found near transcription factors.…”
Section: Akt3 and Znf238 Are Widely Expressed In Brainmentioning
confidence: 99%
“…This is also the region of DNMT3a and DNMT3b that interacts with HDAC1 (and most likely HDAC2). RP58 is a sequence-specific zinc finger DNA binding protein and transcriptional repressor associated with heterochromatin (Aoki et al, 1998;Meng et al, 2000). It contains a POZ domain and several Kru¨ppel-type zinc fingers commonly seen in other transcriptional repressors (Ryan et al, 1999).…”
Section: Rp58mentioning
confidence: 99%
“…Although the ability of DNMT3a and RP58 to cooperate in transcriptional repression was not dependent on the catalytic activity of DNMT3a, it still remains possible that one function of RP58 could be to target DNMT3a to specific DNA sequences that are destined to become de novo methylated. Post-translational modifications, other protein cofactors expressed in a tissue-specific manner (RP58 is highly expressed in the brain for example (Meng et al, 2000)), missing from the cell culture system used to first characterize this interaction, could influence the function of the RP58 -DNMT3a complex.…”
Section: Rp58mentioning
confidence: 99%