Structural analysis of the interaction between human cytokine BMP-2 and the antagonist Noggin reveals molecular details of cell chondrogenesis inhibition

Robert, Charly; Kerff, Frédéric; Bouillenne, Fabrice; Gavage, Maxime; Vandevenne, Marylène; Filée, Patrice; Matagne, André

doi:10.1016/j.jbc.2023.102892

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2024

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Cited by 3 publications

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Combined toxicity of trifloxystrobin and fluopyram to zebrafish embryos and the effect on bone development

Zhang,

Yuan,

Guo

et al. 2024

Aquatic Toxicology

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Combined toxicity of trifloxystrobin and fluopyram to zebrafish embryos and the effect on bone development

Zhang,

Yuan,

Guo

et al. 2024

Aquatic Toxicology

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The future of integrated structural biology

Schwalbe,

Audergon,

Haley

et al. 2024

Structure

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Interleukin-34 orchestrates bone formation through its binding to Bone Morphogenic Proteins

Heymann,

Lézot,

Munoz-Garcia

et al. 2024

Preprint

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During growth, the contribution of IL34, a ligand of MCSFR, have not been established. The aim of this work was therefore to establish these implications using two models of IL34 invalidation generated in zebrafish and mouse. Significant growth delay and hypo-mineralization of skeletal elements were observed in both models, as well as craniofacial dysmorphoses in mice. With regard to bone cells, an unexpected increase in the number of osteoclasts and an accumulation of pre-osteoblasts were observed. In vitro analyses complemented by protein binding and molecular docking studies established that IL34 interacts directly with certain Bone Morphogenetic Proteins, modulating their various activities such as the stimulation of osteoblast differentiation. A new mechanism of action for IL34 has thus been characterized, opening up new therapeutic perspectives.

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Structural analysis of the interaction between human cytokine BMP-2 and the antagonist Noggin reveals molecular details of cell chondrogenesis inhibition

Cited by 3 publications

References 71 publications

Combined toxicity of trifloxystrobin and fluopyram to zebrafish embryos and the effect on bone development

Combined toxicity of trifloxystrobin and fluopyram to zebrafish embryos and the effect on bone development

The future of integrated structural biology

Interleukin-34 orchestrates bone formation through its binding to Bone Morphogenic Proteins

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