Structural and antioxidant studies of a new arabinoxylan from green stem Andrographis paniculata (Kalmegh)

Maity, Gajendra Nath; Maity, Prasenjit; Dasgupta, Asish; Acharya, Krishnendu; Dalai, Sudipta; Mondal, Soumitra

doi:10.1016/j.carbpol.2019.02.051

Cited by 31 publications

(14 citation statements)

References 35 publications

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“…SOD accelerates the conversion of superoxide radicals to hydrogen peroxide while CAT or GPx converts hydrogen peroxide to water. An increase in LPO level was presumably associated with increased free radicals, confirming the fact that the free radicals reduced the antioxidant status in ovary of arsenic-treated mice 35 . The observed alterations might be attributed to the utilization of these antioxidants to alleviate free radical-induced oxidative stress 36 .…”

Section: Resultssupporting

confidence: 52%

“…Anticancer 8 , immunomodulatory, anti-inflammatory 9 , antipyretic , hepatoprotective 10,11 , hypoglycemic 12 , antiplatelet and antioxidant 10, 12 activities have all been reported 13 . Since, AP extract contains diterpenoids, flavonoids, and steroids of which diterpene lactones (andrographolides) are the main components and have been reported to contain various therapeutic efficacies 14,15,16 . Hence, the present study aimed to evaluate the possible pharmacological role of AP in arsenic mediated ovarian dysfunction.…”

Section: Quick Response Codementioning

confidence: 99%

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2019

IJPSR

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The present study was designed to determine the role of Andrographis paniculata (AP; 50 mg/kg) against the oxidative stress caused by the arsenic (0.5 and 1.0 mg/kg) for 30 days in adult mice. The results of in-vivo studies demonstrated that arsenic treatment resulted in a significant dose-dependent increase in the ovarian arsenic level and lipid peroxidation (LPO), followed by a marked reduction in gravimetric data, levels of total ascorbic acid, glutathione and in the activities of superoxide dismutase, catalase, and glutathione peroxidase. A significant reduction in the activities of 3 and 17 hydroxysteroid dehydrogenases along with elevated levels of cholesterol indicated ovarian endocrine dysfunction. These results suggest that an increase in free radical formation relative to loss of antioxidant defense system during arsenic exposure may render ovary more susceptible to oxidative damage leading to their functional inactivation. On the other hand, co-administration of arsenic with Andrographis paniculata (AP) restored altered biochemical variables, antioxidant balance, and gravimetry which suggests that the free radical-mediated damage during arsenic-induced oxidative stress could have been ameliorated by A. paniculata (AP) by its anti-oxidative potential.

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Section: Resultssupporting

confidence: 52%

Section: Quick Response Codementioning

confidence: 99%

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2019

IJPSR

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“…For example, two polysaccharides isolated from Rosa rugosa petals (RRPS, namely RRPS-1 and RRPS-2) were analyzed for their antioxidant activities and it was found that RRPS-2 had a good radical scavenging potential . In addition, a water soluble arabinoxylan (APPS), with a molecular weight of ∼1.49 × 10 5 Da was isolated from the green stem of Andrographis paniculate and showed strong antioxidant activity against superoxide and hydroxyl free radicals (Maity, Maity, & Dasgupta, 2019). Kiwifruit polysaccharides also exhibited high antioxidant activities (Han et al, 2019).…”

Section: Plant Polysaccharidesmentioning

confidence: 99%

“…These molecules play an important role in the development of pharmaceuticals, food, nutritional products, and biodegradable packaging materials (Yu, Shen, Song, & Xie, 2018;Copeland, Blazek, Salman, & Tang, 2009;Yang & Zhang, 2009;Cazon, Velazquez, Ramirez, & Vazquez, 2017). They are commonly derived from plants, fruits, vegetables, herbs, algae, mushrooms, and microorganisms (Kardasova & Machova, 2006;Maity, Maity, & Dasgupta, 2019;Han et al, 2019;Hajji et al, 2019, Liu, Ooi, & Chang, 1997Huang, Siu, Wang, Cheeung, & Wu, 2013;Hu, Gen, Zhang, & Jiang, 2001;Guo et al, 2010;Kodali & Sen, 2008).…”

Section: Introductionmentioning

confidence: 99%

In vitro Antioxidant Activities of Natural Polysaccharides: An overview

Nemzer¹,

Kalita²,

Yashin³

et al. 2019

JFR

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Polysaccharides are naturally occurring biomacromolecules composed of carbohydrate molecules linked by glycosidic bonds. A number of polysaccharides are known to possess beneficial therapeutic effects against inflammation, diabetes, cardiovascular diseases, and cancers. Indeed, polysaccharides are reportedly effective free radical scavengers and antioxidants, thereby playing a critical role in the prevention of damage to living organisms under oxidative stress. In this review we provide an overview of the sources, extraction, and antioxidant activities of some natural polysaccharides.

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“…Tamam, Abd-el-Hamid, Samah, & Marwa [ 12 ] reported antiviral and immunomodulatory activity of Cinnamomum zeylanicum oil against Newcastle disease virus (NDV). Aqueous extract of medicinal plants are enriched with several chemical compounds among which polysaccharides are the most active elements [ 13 ]. Low toxicity, high molecular mass, branching configuration and conformation of polysaccharides may become crucial for generation of suitable immune response in the incident of pathogenic invasion or other viral diseases.…”

Section: Introductionmentioning

confidence: 99%

A review on antiviral and immunomodulatory polysaccharides from Indian medicinal plants, which may be beneficial to COVID-19 infected patients

Sen¹,

Chakraborty

Mandal

et al. 2021

International Journal of Biological Macromolecules

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The emergence of the novel coronavirus, SARS-CoV-2 has pushed forward the world to experience the first pandemic of this century. Any specific drug against this RNA virus is yet to be discovered and presently, the COVID-19 infected patients are being treated symptomatically. During the last few decades, a number of polysaccharides with potential biological activities have been invented from Indian medicinal plants. Many polysaccharides, such as sulfated xylomannan, xylan, pectins, fucoidans, glucans, glucoarabinan, and arabinoxylan from Indian medicinal plants, have been shown to exhibit antiviral and immunomodulating activities. Plant polysaccharides exhibit antiviral activities through interference with the viral life cycle and inhibition of attachment of virus to host cell. Intake of certain immune stimulating plant polysaccharides may also protect from the virus to a certain extent. In process of continuous search for most potent drug, Indian plant polysaccharides may emerge as significant biomaterial to combat COVID-19. This review explores a number of polysaccharides from Indian medicinal plants which showed antiviral and immunomodulating activities. It is aimed to provide an overview about the composition, molecular mass, branching configuration and related bioactivities of polysaccharides which is crucial for their classification as possible drug to induce immune response in viral diseases.

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Structural and antioxidant studies of a new arabinoxylan from green stem Andrographis paniculata (Kalmegh)

Cited by 31 publications

References 35 publications

Untitled

Untitled

In vitro Antioxidant Activities of Natural Polysaccharides: An overview

A review on antiviral and immunomodulatory polysaccharides from Indian medicinal plants, which may be beneficial to COVID-19 infected patients

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