2024
DOI: 10.1101/2024.09.10.612331
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Structural and biochemical characterization of the ALX4 dimer reveals novel insights into how disease alleles impact ALX4 function

Brittany Cain,
Zhenyu Yuan,
Evelyn Thoman
et al.

Abstract: 1.AbstractHow homeodomain proteins gain sufficient DNA binding specificity to regulate diverse processes has been a long-standing question. Here, we determine how the ALX4 Paired-like protein achieves DNA binding specificity for a TAAT – NNN – ATTA dimer site. We first show that ALX4 binds this motif independently of its co-factor, TWIST1, in cranial neural crest cells. Structural analysis identified seven ALX4 residues that participate in dimer binding, many of which are conserved across the Paired-like famil… Show more

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