Structural and Functional Analyses in Nonarteritic Anterior Ischemic Optic Neuropathy: Optical Coherence Tomography Angiography Study

Hata, Masaharu; Oishi, Akio; Muraoka, Yuki; Miyamoto, Kazuaki; Kawai, Kentaro; Yokota, Satoshi; Fujimoto, Masahiro; Miyata, Manabu; Yoshimura, Nagahisa

doi:10.1097/wno.0000000000000470

Cited by 70 publications

(72 citation statements)

References 19 publications

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“…A significant correlation between the peripapillary vessel density and pRNFL thickness in chronic NAION has been described [9]. Similarly, we found a significant correlation between temporal pRNFL thickness and PCD at temporal quadrant (0.635; p = 0.032).…”

Section: Discussionsupporting

confidence: 85%

“…In this patient, the predominantly superior location of the peripapillary microvascular abnormalities detected with OCT-A matched the correspondent inferior VF loss and superior GCIPL thinning. Similar findings have been reported using OptoVue [9,10].…”

Section: Discussionsupporting

confidence: 80%

“…A decrease in the peripapillary microvasculature has been reported in acute [3][4][5][6] and chronic NAION [5,[7][8][9][10][11]. Most studies have used OCT-A Angiovue (Optovue) providing quantitative values for vessel and flow density.…”

Section: Doi: 101159/000489226mentioning

confidence: 99%

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Reduction of Peripapillary Vessel Density by Optical Coherence Tomography Angiography from the Acute to the Atrophic Stage in Non-Arteritic Anterior Ischaemic Optic Neuropathy

et al. 2018

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Purpose: To analyse superficial peripapillary vascularization in non-arteritic anterior ischaemic optic neuropathy (NAION) at acute and atrophic (3 months) stage. Procedures: Prospective case-control study including 6 patients with NAION and 10 age-matched healthy controls evaluated with optical coherence tomography angiography (OCT-A; Angioplex-Cirrus) at acute and atrophic stage. Apart from the commercially provided measurements for vessel density (VD) and perfusion density (PD), a custom image analysis was used to quantify the peripapillary capillary density (PCD). Results: NAION-group demonstrated a significant decrease in the PCD, VD and PD compared with fellow unaffected and control groups at acute and atrophic stage. At 3 months, the average and the temporal sector in PCD correlated with logMAR VA (–0.943, p = 0.005 and –0.829, p = 0.042 for average and temporal sectors respectively) and with MD (0.943, p = 0.005; and 0.899; p = 0.015, respectively). Over 3 months, there was a significant PCD reduction at the temporal sector and at the inner circle in VD and PD, which correlated with ganglion cell–inner plexiform layer (GCIPL) thinning over the 3 months period after the acute NAION (0.749, p = 0.020; 0.885, p = 0.002; 0.767, p = 0.016 respectively). Conclusion: Both strategies demonstrated a significant peripapillary microvascular dropout in NAION, but the customized analysis detected them earlier. A progressive vessel reduction occurs within the first 3 months, which correlates with GCIPL thinning.

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Section: Discussionsupporting

confidence: 85%

Section: Discussionsupporting

confidence: 80%

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Reduction of Peripapillary Vessel Density by Optical Coherence Tomography Angiography from the Acute to the Atrophic Stage in Non-Arteritic Anterior Ischaemic Optic Neuropathy

et al. 2018

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“…Interestingly, while the peripapillary RNFL and visual field defect correlated with peripapillary vessel density, they did not correlate with optic nerve head vessel density. They hypothesized that this may be due to the fact that in acute non-arteritic ischemic optic neuropathy, disc swelling may cause additional damage to neighboring capillaries within the optic nerve head, leading to more diffusely reduced vessel density within the optic nerve head (Hata, Oishi et al 2016). Falavarjani et al also recently described the findings of 21 eyes with disc edema, pseudoedema, or atrophy as compared to healthy normal eyes using SS-OCTA.…”

Section: Review Of Clinical Studies Utilizing Octamentioning

confidence: 99%

Optical coherence tomography angiography: A comprehensive review of current methods and clinical applications

Kashani

Chen

Gahm

et al. 2017

Progress in Retinal and Eye Research

768

561

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OCT has revolutionized the practice of ophthalmology over the past 10 to 20 years. Advances in OCT technology have allowed for the creation of novel OCT-based methods. OCT-Angiography (OCTA) is one such method that has rapidly gained clinical acceptance since it was approved by the FDA in late 2016. OCTA images are based on the variable backscattering of light from the vascular and neurosensory tissue in the retina. Since the intensity and phase of backscattered light from retinal tissue varies based on the intrinsic movement of the tissue (e.g. red blood cells are moving, but neurosensory tissue is static), OCTA images are essentially motion-contrast images. This motion-contrast imaging provides reliable, high resolution, and non-invasive images of the retinal vasculature in an efficient manner. In many cases, these images are approaching histology level resolution. This unprecedented resolution coupled with the simple, fast and non-invasive imaging platform have allowed a host of basic and clinical research applications. OCTA has been shown to demonstrate many important clinical findings including areas of macular telangiectasia, impaired perfusion, microaneurysms, capillary remodeling, some types of intraretinal fluid, and neovascularization among many others. More importantly, OCTA provides depth-resolved information that has never before been available. Correspondingly, OCTA has been used to evaluate a spectrum of retinal vascular diseases including diabetic retinopathy (DR), retinal venous occlusion (RVO), uveitis, retinal arterial occlusion, and age-related macular degeneration among others. In this review, we will discuss the methods used to create OCTA images, the practical applications of OCTA in light of invasive dye-imaging studies (e.g. fluorescein angiography) and review clinical studies demonstrating the utility of OCTA for research and clinical practice.

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“…Non-arteritic anterior ischaemic optic neuropathy (NAION) is a kind of serious ischaemic optic neuropathy, patients with NAION show a sudden, painless, decrease in vision accompanied with a visual field defect and optic disc edema [1][2][3][4]. It's believed that the pathogenesis of NAION is multifactorial [5,6], and the hypoperfusion of short posterior ciliary arteries (SPCAs) was proved to be the major cause [7].…”

Section: Introductionmentioning

confidence: 99%

Analyses of the relation between internal carotid artery siphon and non-arteritic anterior ischaemic optic neuropathy

Wang³

2020

Preprint

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Structural and Functional Analyses in Nonarteritic Anterior Ischemic Optic Neuropathy: Optical Coherence Tomography Angiography Study

Cited by 70 publications

References 19 publications

Reduction of Peripapillary Vessel Density by Optical Coherence Tomography Angiography from the Acute to the Atrophic Stage in Non-Arteritic Anterior Ischaemic Optic Neuropathy

Reduction of Peripapillary Vessel Density by Optical Coherence Tomography Angiography from the Acute to the Atrophic Stage in Non-Arteritic Anterior Ischaemic Optic Neuropathy

Optical coherence tomography angiography: A comprehensive review of current methods and clinical applications

Analyses of the relation between internal carotid artery siphon and non-arteritic anterior ischaemic optic neuropathy

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