Structural and functional cardiovascular changes and their consequences following interventional patent ductus arteriosus occlusion in dogs: 24 cases (2000–2006)

Stauthammer, Christopher D.; Tobias, Anthony H.; Leeder, Damon; Kruger, Maxie

doi:10.2460/javma.242.12.1722

Cited by 16 publications

(37 citation statements)

References 20 publications

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“…At long‐term follow‐up, median FS was 28%, and 5 of 14 dogs with baseline FS <25% had values between 20 and 25%. Despite evidence of systolic dysfunction, these dogs were clinically doing well, similar to previous studies 13, 28. As with left ventricular dimensions, long‐term changes in left ventricular FS can be complicated by residual flow and acquired HD including DMVD 5…”

Section: Discussionsupporting

confidence: 78%

“…One‐ and 2‐year survival rates after PDA ligation are 92 and 87%, respectively 18. Median survival in 24 dogs with uncomplicated PDA was >11.5 years after ductal occlusion 13. In 1 study, maximum survival time was significantly longer with PDA closure (168 months) compared with dogs that were not occluded (114 months) 5.…”

Section: Discussionmentioning

confidence: 96%

“…Published information regarding long‐term changes in cardiac size and function after PDA closure in dogs is limited. Long‐term outcome generally is good after PDA closure, especially in uncomplicated cases 1, 12, 13…”

mentioning

confidence: 99%

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Long‐Term Outcome in Dogs with Patent Ductus Arteriosus: 520 Cases (1994–2009)

Saunders

Gordon

Boggess

et al. 2013

Veterinary Internal Medicne

111

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BackgroundPublished information regarding survival and long‐term cardiac remodeling after patent ductus arteriosus (PDA) closure in dogs is limited.ObjectivesTo report outcome and identify prognostic variables in dogs with PDA, and to identify risk factors for persistent remodeling in dogs with a minimum of 12 months of follow‐up after closure.AnimalsFive hundred and twenty client‐owned dogs.MethodsRetrospective review of medical records of 520 dogs with PDA. Outcome was determined by contacting owners and veterinarians. Dogs with PDA closure and ≥ 12 months of follow‐up were asked to return for a re‐evaluation.ResultsIn multivariable analysis of 506 dogs not euthanized at the time of diagnosis, not having a PDA closure procedure negatively affected survival (HzR = 16.9, P < .001). In 444 dogs undergoing successful PDA closure, clinical signs at presentation (HzR = 17, P = .02), concurrent congenital heart disease (HD) (HzR = 4.8, P = .038), and severe mitral regurgitation (MR) documented within 24 hours of closure (HzR = 4.5, P = .028) negatively affected survival. Seventy‐one dogs with ≥ 12 months follow‐up demonstrated a significant reduction in radiographic and echocardiographic measures of heart size (P = 0) and increased incidence of acquired HD (P = .001) at re‐evaluation. Dogs with increased left ventricular size and low fractional shortening at baseline were more likely to have persistent remodeling at re‐evaluation.Conclusions and Clinical ImportancePatent ductus arteriosus closure confers important survival benefits and results in long‐term reverse remodeling in most dogs. Clinical signs at presentation, concurrent congenital HD, and severe MR negatively affect survival. Increased left ventricular systolic dimensions and systolic dysfunction at baseline correlated significantly with persistent remodeling.

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Section: Discussionsupporting

confidence: 78%

Section: Discussionmentioning

confidence: 96%

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Long‐Term Outcome in Dogs with Patent Ductus Arteriosus: 520 Cases (1994–2009)

Saunders

Gordon

Boggess

et al. 2013

Veterinary Internal Medicne

111

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“…[6][7][8][29][30][31] These hemodynamic changes were investigated by standard transthoracic echocardiography in previous studies in humans and animals. [11][12][13][14][15][29][30][31][32][33][34] As a consequence of PDA closure and decreased preload, end-diastolic dimensions (EDVI M-B , AlloD) as well as end-systolic dimensions (ESVI M-B , AlloS) decrease, although they rarely normalize in the short term. [6][7][8][11][12][13][14][15][29][30][31][32][33][34] A more pronounced decrease in diastolic dimensions generally is appreciated, whereas systolic dimensions appear to decrease but to a lesser extent as compared to diastolic dimensions after PDA closure.…”

Section: Discussionmentioning

confidence: 99%

“…[11][12][13][14][15] Dogs with PDA show increases in end-diastolic and end-systolic dimensions, which tend to decrease after PDA closure. Marked decrease in fractional shortening (FS) and ejection fraction (EF) are associated findings, [11][12][13][14][15] with some patients showing EF and FS values below reference ranges; [11][12][13][14][15] but no change in long-term survival was identified by previous studies. 14,15 The speculation that PDA closure in young patients may be accompanied by LV systolic dysfunction because of the inability of the LV to compensate for acute loading changes can be further investigated by advanced imaging modalities.…”

mentioning

confidence: 99%

Speckle‐Tracking Echocardiography in Dogs With Patent Ductus Arteriosus: Effect of Percutaneous Closure on Cardiac Mechanics

Spalla

Locatelli

Zanaboni

et al. 2016

Veterinary Internal Medicne

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BackgroundPatent ductus arteriosus (PDA) is 1 of the most common congenital heart defects in dogs and percutaneous closure is effective in achieving ductal closure; PDA closure is associated with abrupt hemodynamic changes.HypothesisA marked decrease in standard parameters of systolic function as assessed by M‐ or B‐mode echocardiography after PDA closure was identified in previous studies. Speckle tracking echocardiography can provide further insight into the effect of PDA closure on cardiac mechanics in dogs affected by PDA.AnimalsTwenty‐five client‐owned dogs with PDA.MethodsProspective study. Dogs were recruited over a 2‐year period. Complete echocardiographic evaluation was performed before and 24 hours after PDA closure, including standard (end‐diastolic volumes indexed to body surface area in B‐ and M‐mode [EDVIB /M], end‐systolic volumes indexed to body surface area in B‐ and M‐mode [ESVIB /M], allometric scaling in diastole [AlloD] and systole [AlloS], pulmonary flow to systemic flow [Qs/Qp], ejection fraction [EF], and fractional shortening [FS]), and advanced speckle‐tracking echocardiography (STE): global longitudinal, radial, circumferential and transverse strain (S), and strain rate (SR).ResultsPatent ductus arteriosus closure was associated with statistically significant decreases in EDVIM /B and ESVIM /B, AlloD and AlloS, SI, EF, and FS. A statistically significant decrease in the absolute values of radial, transverse, and circumferential S and SR was observed, whereas longitudinal S and SR did not change significantly.Conclusion and Clinical ImportancePatent ductus arteriosus closure by percutaneous approach is associated with marked decreases of conventional echocardiographic parameters as a result of the changes in loading conditions, but no evidence of systolic dysfunction was identified by means of STE, as none of the S and SR values were below reference ranges. In the short term, contractility is enhanced in the long axis (long S/SR values were not statistically different before and after closure) and decreases to normal values in short axis (circumferential, radial, and transversal S/SR decreased to normal reference range).

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Patent Ductus Arteriosus

Stauthammer

2015

Veterinary Image‐Guided Interventions

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Structural and functional cardiovascular changes and their consequences following interventional patent ductus arteriosus occlusion in dogs: 24 cases (2000–2006)

Cited by 16 publications

References 20 publications

Long‐Term Outcome in Dogs with Patent Ductus Arteriosus: 520 Cases (1994–2009)

Long‐Term Outcome in Dogs with Patent Ductus Arteriosus: 520 Cases (1994–2009)

Speckle‐Tracking Echocardiography in Dogs With Patent Ductus Arteriosus: Effect of Percutaneous Closure on Cardiac Mechanics

Patent Ductus Arteriosus

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