2010
DOI: 10.1111/j.1530-0277.2010.01176.x
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Structural and Functional Effects of Developmental Exposure to Ethanol on the Zebrafish Heart

Abstract: These results show that exposure of the zebrafish to ethanol during development results in structural and functional changes in the heart that mimic malformations that occur in patients with fetal alcohol syndrome (FAS). These findings promote the zebrafish heart as a future model for investigating the mechanisms responsible for ethanol's adverse effects on vertebrate heart development.

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Cited by 35 publications
(28 citation statements)
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“…For instance, 0.5% ethanol can cause significant increases in the occurrence of cardiac edema, reduction in heart volume, and reduced ventricular thickness. 39 Slightly higher doses of 100 or 150 mM (0.6%-0.9%) can disrupt cardiac precursor migration, heart looping, and cardiac gene expression. 40 The zebrafish inner ear is disrupted in embryos treated with 2% ethanol.…”
Section: Zebrafish Models Of Fasdmentioning
confidence: 99%
“…For instance, 0.5% ethanol can cause significant increases in the occurrence of cardiac edema, reduction in heart volume, and reduced ventricular thickness. 39 Slightly higher doses of 100 or 150 mM (0.6%-0.9%) can disrupt cardiac precursor migration, heart looping, and cardiac gene expression. 40 The zebrafish inner ear is disrupted in embryos treated with 2% ethanol.…”
Section: Zebrafish Models Of Fasdmentioning
confidence: 99%
“…In order to best understand the damage produced by ethanol, plus produce a model with which to test potential interventions, we developed a model of developmental ethanol exposure using the zebrafish embryo. Zebrafish are ideal for this kind of teratogen study [3][4][5][6][7][8] . Each pair lays hundreds of eggs, which can then be collected without harming the adult fish.…”
mentioning
confidence: 99%
“…Abnormal embryonic cardiac function (as well as abnormal valves) was identified through ultrasound and histology, respectively at late stages (embryonic day 15.5) [italics researchers] of mouse development after ethanol exposure at gastrulation [27,28]. Functional and structural defects, including anomalies in heart volume/ morphology and conduction, were observed in latestage zebrafish after ethanol exposure, thus mimicking malformations occurring in patients with FASD [29].…”
Section: Congenital Heart Defects and Fetal Alcohol Spectrum Disordermentioning
confidence: 99%