2014
DOI: 10.1105/tpc.113.118588
|View full text |Cite
|
Sign up to set email alerts
|

Structural and Functional Modularity of the Orange Carotenoid Protein: Distinct Roles for the N- and C-Terminal Domains in Cyanobacterial Photoprotection  

Abstract: The orange carotenoid protein (OCP) serves as a sensor of light intensity and an effector of phycobilisome (PB)-associated photoprotection in cyanobacteria. Structurally, the OCP is composed of two distinct domains spanned by a single carotenoid chromophore. Functionally, in response to high light, the OCP converts from a dark-stable orange form, OCP O , to an active red form, OCP R . The C-terminal domain of the OCP has been implicated in the dynamic response to light intensity and plays a role in switching o… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1

Citation Types

12
147
0

Year Published

2015
2015
2021
2021

Publication Types

Select...
6
2

Relationship

3
5

Authors

Journals

citations
Cited by 123 publications
(159 citation statements)
references
References 34 publications
12
147
0
Order By: Relevance
“…Simultaneously, a 2.2 Å decrease of the distance between the TMR dimer in the NTD and ECN was observed (Fig. 5), which is in line with the data considering that ECN in the red form stays in the NTD and even penetrates deeper into the protein core (15,18). It should be noted that the Förster theory considers donor and acceptor as point-like electromagnetic oscillators, i.e., objects without size and shape.…”
Section: Discussionsupporting
confidence: 87%
See 2 more Smart Citations
“…Simultaneously, a 2.2 Å decrease of the distance between the TMR dimer in the NTD and ECN was observed (Fig. 5), which is in line with the data considering that ECN in the red form stays in the NTD and even penetrates deeper into the protein core (15,18). It should be noted that the Förster theory considers donor and acceptor as point-like electromagnetic oscillators, i.e., objects without size and shape.…”
Section: Discussionsupporting
confidence: 87%
“…Although the structure of the red form of OCP is still unknown, recent efforts provided valuable information about photoinduced rearrangements of OCP (15)(16)(17)(18)(19)(20). It appeared that the red carotenoid protein (RCP), which is a spectral and functional analog of OCP R , could be obtained by partial proteolysis of OCP upon removal of its C-terminal domain (CTD) (15).…”
Section: Introductionmentioning
confidence: 99%
See 1 more Smart Citation
“…Previously, it has been demonstrated that the N-terminal globular domain of the OCP (green in Fig. 1, A and B) is a constitutively active energy quencher (Leverenz et al, 2014). Thus, its interaction with the C-terminal globular domain is essential for inhibiting OCP binding to PBS and energy quenching under low irradiance.…”
mentioning
confidence: 99%
“…The isolated NTD acts as an effector domain that binds to the antenna whereas the CTD has been proposed to play a sensory/regulatory role in controlling the OCP's photoprotective function (6). Exposure to blue light converts OCP O to the active (red) form, OCP R (7).…”
mentioning
confidence: 99%