Structural and functional myocardial abnormalities and arrhythmias in patients with type 1 diabetes complicated with ketoacidosis

Muha, N.V.; Говорин, А. В.; Зайцев, Д. Н.; Филев, А. П.

doi:10.15829/1560-4071-2020-3891

Cited by 3 publications

(2 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Выявленные изменения МЦР у больных СД-1, осложненным ДКА, возможно объяснить констрикцией метаартериол и прекапилляров в результате рос та симпатической активности и увеличения миогенного тонуса сосудов. Этот факт подтверждается и проведенным нами ранее исследованием у па циентов с СД, которое демонстрируют наличие вегетативного дисбаланса с преобладанием симпатических влияний на сердечный ритм и снижением защитного вагусного контроля сердечной деятельности [5]. Увеличение внутрисосудистого сопро тивления сопровождается снижением нутритивного кровотока.…”

Section: результатыunclassified

Microcirculation disorders and structural and functional left ventricular abnormalities in patients with type 1 diabetes complicated by ketoacidosis

et al. 2020

Self Cite

View full text Add to dashboard Cite

Aim. To assess the patterns of microcirculation disorders and its effect on the left ventricular (LV) structure and function in patients with type 1 diabetes (T1D) complicated by diabetic ketoacidosis (DKA).Material and methods. The study included 128 patients with T1D complicated by DKA. Echocardiography was performed according to the standard technique. To study the microcirculation and vascular tone regulation, we used a laser Doppler flowmetry (LDF) using the LAKK-02 machine (Lazma, Russia).Results. In patients with T1D complicated by DKA, there was an increase in thepassive blood flow modulation with a depression of active factors. The most pronounced changes are recorded in 1-5 days of the disease. Along with this, a spectral redistribution in favour of respiratory and cardiac microcirculation ranges was demonstrated. With DKA, the myocardial remodelling is recorded: an increase in left atrial (LA) size by 5,6%, LV end systolic and diastolic dimension and volume by 5,3% and 6,7%, respectively, LV mass by 17,3% and LV mass index by 17,8%. Decreased LV ejection fraction (EF) in comparison with healthy individuals was obtained. Significant unidirectional changes in these parameters were revealed in comparison with the T1D patients without DKA.Conclusion. In patients with T1D complicated by DKA, the microcirculation decreases, as a result of which the adequate tissue supply is limited, vascular resistance and hemodynamic load increases, which leads to LV structural and functional changes.

show abstract

Section: результатыunclassified

Microcirculation disorders and structural and functional left ventricular abnormalities in patients with type 1 diabetes complicated by ketoacidosis

et al. 2020

Self Cite

View full text Add to dashboard Cite

show abstract

“…Показано, что смертность при СД-1 типа от ДКА в среднем составляет около 5% [5]. Для больных сахарным диабетом характерно атеротромботическое состояние, обусловленное множественными нарушениями в системе гемостаза, включая эндотелиальную дисфункцию, подавление фибринолитической активности, а также различные нарушения функции тромбоцитов [6][7][8]. Возникающее при острой и хронической гипергликемии повышение функциональной активности тромбоцитов и снижение антитромбогенных свойств сосудистой стенки может создать условия для возникновения внутрисосудистой агрегации тромбоцитов, их адгезии к сосудистой стенке и развитию острых сосудистых осложнений [9].…”

unclassified

Platelet Aggregation Function in Patients With Type 1 Diabetes Mellitus With Ketoacidosis of Varying Degrees of Severity

Mukha,

Govirin,

Filev

et al. 2024

jour

View full text Add to dashboard Cite

The aim of the research. To study the aggregation function of platelets in the blood of patients with type 1 diabetes mellitus complicated by ketoacidosis, depending on the severity of ketoacidosis in the dynamics of the disease.Materials and methods. 135 patients with type 1 diabetes mellitus complicated by mild and moderate ketoacidosis were examined, respectively, on the 1st, 5th and 10th days of the disease. The average age of the patients was 29,2±8,9 years. Platelet aggregation was studied using a Biola two-channel laser platelet aggregation analyzer (model LA230, Russia).Results. It was found that in patients with type 1 diabetes mellitus complicated by moderate and severe ketoacidosis, spontaneous platelet aggregation was sharply increased compared with patients with type 1 diabetes mellitus complicated by mild ketoacidosis. The most pronounced changes were registered on the 1st and 5th days of the disease in patients with type 1 diabetes mellitus complicated by moderate and severe ketoacidosis, and on the 5th day in the same cohort of patients complicated by mild ketoacidosis.Conclusion. Clinically significant laboratory parameters in patients with type 1 diabetes mellitus complicated by ketoacidosis, indirectly indicating hypercoagulation, require drug correction.

show abstract

Adipokines and the cardiorespiratory system in young patients with type 1 diabetes mellitus

Vengrzhinovskaya¹,

Bondarenko²,

Shatskaya³

et al. 2022

Terapevticheskii arkhiv

View full text Add to dashboard Cite

Early screening of complications of diabetes mellitus (DM) is one of the priorities for public health. Most patients with type 1 diabetes mellitus (T1DM) are patients of working age. New strategies for the primary prevention of cardiovascular disease (CVD) are needed to prevent their early disability. Aim. To assess the predictive value of adipokines in relation to a personalized approach to the need for an in-depth examination of young patients with T1DM. Materials and methods. The study included 98 patients without CVD: 70 patients with T1DM (mean age 26.48.1 years) and 28 patients without DM (mean age 279 years). All patients underwent a general clinical examination, the levels of adipokines were determined, ergospirometry, echocardiography, and bioimpedancemetry were performed. Results. Changes in the cardiorespiratory system in patients with T1DM were revealed, in comparison with persons without T1DM: anaerobic threshold was reached faster (p=0.001), maximum oxygen consumption was lower (p=0.048), metabolic equivalent was reduced (p=0.0001). Signs of myocardial remodeling were found in the T1DM group: there was an increase in the relative wall thickness (p=0.001), the posterior wall of the left ventricle (p=0.001), myocardial mass index (p=0.049), in comparison with persons without T1DM. Changes in the adipokines system were revealed: higher levels of resistin (p=0.002) and visfatin (p=0.001), lower level of adiponectin (p=0.040) in T1DM. A positive correlation was found between posterior wall of the left ventricle and visfatin (p=0.014) and a negative relationship between adiponectin and relative wall thickness (p=0.018) in T1DM. Conclusion. In T1DM, even at a young age, there are multifactorial changes in the heart, which can be detected even at the preclinical stage. The data obtained can be used to identify groups of patients at high risk of developing dangerous CVD in T1DM, which can form the basis for determining the timing of the start of preventive therapy.

show abstract

Structural and functional myocardial abnormalities and arrhythmias in patients with type 1 diabetes complicated with ketoacidosis

Cited by 3 publications

References 7 publications

Microcirculation disorders and structural and functional left ventricular abnormalities in patients with type 1 diabetes complicated by ketoacidosis

Microcirculation disorders and structural and functional left ventricular abnormalities in patients with type 1 diabetes complicated by ketoacidosis

Platelet Aggregation Function in Patients With Type 1 Diabetes Mellitus With Ketoacidosis of Varying Degrees of Severity

Adipokines and the cardiorespiratory system in young patients with type 1 diabetes mellitus

Contact Info

Product

Resources

About