Structural and functional network mechanisms of rescuing cognitive control in aging

Jones, Kevin T.; Johnson, Elizabeth L.; Gazzaley, Adam; Zanto, Theodore P.

doi:10.1016/j.neuroimage.2022.119547

Cited by 13 publications

(15 citation statements)

References 80 publications

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“…We recently demonstrated that tACS in the theta range (6 Hz) improves cognitive control in healthy younger adults across a single session of CCT 17 , 18 . In healthy older adults we also observed that 6 Hz theta tACS applied during CCT enhanced multitasking more than sham 38 or 1 Hz delta 28 tACS. These prior results guided our pre-registered approach in the current study, as we included a frequency control (delta) as opposed to a duration control (sham) in the current study.…”

Section: Introductionsupporting

confidence: 53%

“…4 ). In our past research employing tACS with paired cognitive training, we observed behavioral gains following just three sessions in healthy older adults 28 , 38 and five in healthy younger adults 39 . Here, we assess gains in outcome measures at the 1-week and 1-month time points to measure gains and how additional sessions maintain or further rescue cognitive gains in MCI patients.…”

Section: Methodsmentioning

confidence: 84%

“…The applied oscillatory electrical stimulation results in the recruitment of neurons to join a local oscillating network, that affects both local and broad network computations 22 , 23 . The oscillatory entrainment from tACS leads to changes in observed amplitude 24 , frequency 25 , coherence 24 , 26 , 27 , connectivity 28 , 29 , and cross-frequency activity 29 , 30 in the EEG and in resting-state fMRI 31 (further reviewed in: 32 , 33 ), believed to be due to enhanced cortical plasticity 34 , 35 . This lasting aftereffect or plasticity can impact behavior in cognitive tasks 24 , 35 , making tACS an ideal tool to pair with CCT in vulnerable populations.…”

Section: Introductionmentioning

confidence: 99%

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Enhancing cognitive control in amnestic mild cognitive impairment via at-home non-invasive neuromodulation in a randomized trial

Jones

Ostrand

Gazzaley

et al. 2023

Sci Rep

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Individuals with multi-domain amnestic mild cognitive impairment (md-aMCI) have an elevated risk of dementia and need interventions that may retain or remediate cognitive function. In a feasibility pilot study, 30 older adults aged 60–80 years with md-aMCI were randomized to 8 sessions of transcranial alternating current stimulation (tACS) with simultaneous cognitive control training (CCT). The intervention took place within the participant’s home without direct researcher assistance. Half of the participants received prefrontal theta tACS during CCT and the other half received control tACS. We observed high tolerability and adherence for at-home tACS + CCT. Within 1-week, only those who received theta tACS exhibited improved attentional abilities. Neuromodulation is feasible for in-home settings, which can be conducted by the patient, thereby enabling treatment in difficult to reach populations. TACS with CCT may facilitate cognitive control abilities in md-aMCI, but research in a larger population is needed to validate efficacy.

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Section: Introductionsupporting

confidence: 53%

Section: Methodsmentioning

confidence: 84%

Section: Introductionmentioning

confidence: 99%

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Enhancing cognitive control in amnestic mild cognitive impairment via at-home non-invasive neuromodulation in a randomized trial

Jones

Ostrand

Gazzaley

et al. 2023

Sci Rep

Self Cite

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“…PLV EEG is used to remotely examine the task-induced changes in neural activities, synchronized in EEG recordings, which is a classic metric for computing functional brain connectivity features. Jones et al (2022) have used PLV EEG functional connectivity features as an evaluation metric for assessing the efficacy of transcranial alternating current stimulation (tACS) on age-associated cognitive decline. Li et al (2022) have constructed a model combining the clinical and PLV EEG features to diagnose Alzheimer’s disease (AD), which exhibits satisfactory performance and robustness.…”

Section: Discussionmentioning

confidence: 99%

An objective model for diagnosing comorbid cognitive impairment in patients with epilepsy based on the clinical-EEG functional connectivity features

et al. 2023

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ObjectiveCognitive impairment (CI) is a common disorder in patients with epilepsy (PWEs). Objective assessment method for diagnosing CI in PWEs would be beneficial in reality. This study proposed to construct a diagnostic model for CI in PWEs using the clinical and the phase locking value (PLV) functional connectivity features of the electroencephalogram (EEG).MethodsPWEs who met the inclusion and exclusion criteria were divided into a cognitively normal (CON) group (n = 55) and a CI group (n = 76). The 23 clinical features and 684 PLVEEG features at the time of patient visit were screened and ranked using the Fisher score. Adaptive Boosting (AdaBoost) and Gradient Boosting Decision Tree (GBDT) were used as algorithms to construct diagnostic models of CI in PWEs either with pure clinical features, pure PLVEEG features, or combined clinical and PLVEEG features. The performance of these models was assessed using a five-fold cross-validation method.ResultsGBDT-built model with combined clinical and PLVEEG features performed the best with accuracy, precision, recall, F1-score, and an area under the curve (AUC) of 90.11, 93.40, 89.50, 91.39, and 0.95%. The top 5 features found to influence the model performance based on the Fisher scores were the magnetic resonance imaging (MRI) findings of the head for abnormalities, educational attainment, PLVEEG in the beta (β)-band C3-F4, seizure frequency, and PLVEEG in theta (θ)-band Fp1-Fz. A total of 12 of the top 5% of features exhibited statistically different PLVEEG features, while eight of which were PLVEEG features in the θ band.ConclusionThe model constructed from the combined clinical and PLVEEG features could effectively identify CI in PWEs and possess the potential as a useful objective evaluation method. The PLVEEG in the θ band could be a potential biomarker for the complementary diagnosis of CI comorbid with epilepsy.

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“…The acquisition of novel motor skills, a cornerstone of human behavior, underscores the signi cance of motor learning [44]. Numerous research articles have con rmed the bene cial impact of tACS, particularly 40 Hz tACS, in exploring memory [45], learning [46] and higher cognitive function [11,47], all of which are pivotal for effective motor learning. Despite these ndings, the impact of 40 Hz tACS on the motor learning of stroke patients is still unclear.…”

Section: Discussionmentioning

confidence: 99%

Effectiveness and brain mechanism of 40 Hz multitarget transcranial alternating current stimulation (tACS) on motor learning in stroke patients: Study protocol for a randomized controlled trial

Lai,

Yu,

et al. 2023

Preprint

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Background:40 Hz transcranial alternating current stimulation (tACS) has proven to be an effective treatment for improving cognition, a crucial factor in motor learning. However, current studies are predominantly focused on the motor cortex, and the potential brain mechanisms responsible for the therapeutic effects are still unclear. Given the interconnected nature of motor learning within the brain network, we have proposed a novel approach known as multitarget tACS. This study aims to ascertain whether multitarget tACS is more effective than single-target stimulation in stroke patients and to further explore the potential underlying brain mechanisms by using techniques such as transcranial magnetic stimulation (TMS) and magnetic resonance imaging (MRI). Methods: This study employs a double-blind, sham-controlled, randomized controlled trial design with a 2-week intervention period. Both participants and outcome assessors will remain unaware of treatment allocation throughout the study. Thirty-nine stroke patients will be recruited and randomized into three distinct groups, including the sham tACS group (SS group), the single-target tACS group (ST group), and the multitarget tACS group (MT group), at a 1:1:1 ratio. The primary outcomes are series reaction time tests (SRTTs) combined with electroencephalograms (EEGs). The secondary outcomes include motor evoked potential (MEP), central motor conduction time (CMCT), short interval intracortical inhibition (SICI), intracortical facilitation (ICF), magnetic resonance imaging (MRI), box and block test (BBT) and blood sample RNA sequencing. The tACS interventions for all three groups will be administered over a 2-week period, with outcome assessments conducted at baseline (T0) and 1 day (T1), 7 days (T2), and 14 days (T3) of the intervention phase. Discussion: The study’s findings will determine the potential of 40 Hz tACS to improve motor learning in stroke patients. Additionally, it will compare the effectiveness of multitarget and single-target approaches, shedding light on their respective improvement effects. Through the utilization of techniques such as TMS and MRI, the study aims to uncover the underlying brain mechanisms responsible for the therapeutic impact. Furthermore, the intervention has the potential to facilitate motor learning efficiency, thereby contributing to the advancement of future stroke rehabilitation treatment. Trial registration: Chinese Clinical Trial Registry ChiCTR2300073465. Registered on July 11, 2023.

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Structural and functional network mechanisms of rescuing cognitive control in aging

Cited by 13 publications

References 80 publications

Enhancing cognitive control in amnestic mild cognitive impairment via at-home non-invasive neuromodulation in a randomized trial

Enhancing cognitive control in amnestic mild cognitive impairment via at-home non-invasive neuromodulation in a randomized trial

An objective model for diagnosing comorbid cognitive impairment in patients with epilepsy based on the clinical-EEG functional connectivity features

Effectiveness and brain mechanism of 40 Hz multitarget transcranial alternating current stimulation (tACS) on motor learning in stroke patients: Study protocol for a randomized controlled trial

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