2020
DOI: 10.1101/2020.09.02.280008
|View full text |Cite
Preprint
|
Sign up to set email alerts
|

Structural and mechanistic basis of the EMC-dependent biogenesis of distinct transmembrane clients

Abstract: Membrane protein biogenesis in the endoplasmic reticulum (ER) is complex and failure-prone. The ER membrane protein complex (EMC), comprising eight conserved subunits, has emerged as a central player in this process. Yet, we have limited understanding of how EMC enables insertion and integrity of diverse clients, from tail-anchored to polytopic transmembrane proteins. Here, yeast and human EMC cryo-EM structures reveal conserved intricate assemblies and human-specific features associated with pathologies. Stru… Show more

Help me understand this report
View published versions

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

0
0
0

Publication Types

Select...

Relationship

0
0

Authors

Journals

citations
Cited by 0 publications
references
References 127 publications
(76 reference statements)
0
0
0
Order By: Relevance

No citations

Set email alert for when this publication receives citations?