Structural and spectroscopic investigation on a new potentially bioactive di-hydrazone containing thiophene heterocyclic rings

Antioxidant and Anticancer Activity of Novel Derivatives of 3-[(4-Methoxyphenyl)amino]propanehydrazide

“…It has been established that the biological activity of hydrazone compounds is associated with the presence of the active azomethine -NH-N=CH- pharmacophore [ 7 ] and these compounds, in combination with various heterocyclic scaffolds, possess diverse biological activity, including anticancer, antibacterial, antiviral, antiplatelet [ 8 , 9 ], as well as antioxidant one [ 10 , 11 ]. As a model of a hybrid drug, bearing hydrazone and thiophene moieties, 2,5-dimethoxy-terephthalaldehyde bis(thiophene-2-carbonylhydrazone) was synthesized by the condensation reaction between 2,5-dimethoxyterephthalaldehyde and 2-thiophenecarboxylic acid hydrazide to be evaluated by computational pharmacological evaluation for the drug’s pharmacokinetics in the human body and presented a drug score of 45% according to the Lipinski rule of five [ 12 ]. Phthalimide ring (isoindoline-1,3-dione) represents another promising pharmacophore subunit for incorporation into hydrazone molecule.…”

Preparation, characterization and Microbicide activities of N'-((3-(hydroxyimino)butan-2-ylidene)-2-(phenylamino)acetohydrazide and its complexes

“…Both hydrazide and hydrazone compounds have drawn much concern in order to investigate their structures as well as their enormous biomedical activities as: antioxidant [8,9], analgesic, anti-inflammatory [10], antimalarial, anti-leishmanial and anti-trypanosomal [11], anti-convulsant [(12)], antibacterial [13,14], antiplatelet [15], antitumor [16] and antiviral [17,18] activities. The presence of active azomethine NHN=CH-protons in these compounds imparts them a major importance as good candidates for the development of new drugs [19][20][21]. For this behavior, hydrazone derivatives are widely used in organic synthesis as well as designing of new drugs.…”

Physico-Chemical Optimization and Structure-Activity Relationship Studies of Aldehyde-Derived N-Acylhydrazones: Towards the Improvement of Moderate Metal Chelators as a Strategy Against Metal-Enhanced Aggregopathies

“…Additionally, specific absorptions rising from the aromatic substituent in the hydrazide-derived moieties are also present. The thiophene C-S-C stretching, for example, occurs at 852 cm -1 in compound 4d (Nogueira et al, 2016), while a pair of bands related to ν(C-O) modes of the furan ring are noted at 1033 and 957 cm -1 in compound 3d's spectrum (Kwiatkowski et al, 1997). As mentioned before, isoniazid-derived compound 1d was obtained both in its polycrystalline free-base and single crystal hydrochloric (1d') forms.…”