Structural and surface characterization of nanostructured spray dried titanosilicate microspheres

Ponta, O.; Vanea, E.; Cheniti, A.; Berce, Petru; Simon, S.

doi:10.1016/j.matchemphys.2012.05.071

Cited by 10 publications

(4 citation statements)

References 37 publications

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“…The sol–gel method used for obtaining this coating is now preferred to the classical melting method because of its advantages [ 46 ]. It is a much more flexible method for obtaining amorphous multi-component oxide systems of high purity and homogeneity, at lower temperatures, with a controlled porosity [ 47 ]. By forming nanopores in the glass, the surface area becomes enlarged and provides sites for cell attachment [ 48 , 49 ].…”

Section: Discussionmentioning

confidence: 99%

Comparative in vitro study regarding the biocompatibility of titanium-base composites infiltrated with hydroxyapatite or silicatitanate

et al. 2014

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BackgroundThe development of novel biomaterials able to control cell activities and direct their fate is warranted for engineering functional bone tissues. Adding bioactive materials can improve new bone formation and better osseointegration. Three types of titanium (Ti) implants were tested for in vitro biocompatibility in this comparative study: Ti6Al7Nb implants with 25% total porosity used as controls, implants infiltrated using a sol–gel method with hydroxyapatite (Ti HA) and silicatitanate (Ti SiO2). The behavior of human osteoblasts was observed in terms of adhesion, cell growth and differentiation.ResultsThe two coating methods have provided different morphological and chemical properties (SEM and EDX analysis). Cell attachment in the first hour was slower on the Ti HA scaffolds when compared to Ti SiO2 and porous uncoated Ti implants. The Alamar blue test and the assessment of total protein content uncovered a peak of metabolic activity at day 8–9 with an advantage for Ti SiO2 implants. Osteoblast differentiation and de novo mineralization, evaluated by osteopontin (OP) expression (ELISA and immnocytochemistry), alkaline phosphatase (ALP) activity, calcium deposition (alizarin red), collagen synthesis (SIRCOL test and immnocytochemical staining) and osteocalcin (OC) expression, highlighted the higher osteoconductive ability of Ti HA implants. Higher soluble collagen levels were found for cells cultured in simple osteogenic differentiation medium on control Ti and Ti SiO2 implants. Osteocalcin (OC), a marker of terminal osteoblastic differentiation, was most strongly expressed in osteoblasts cultivated on Ti SiO2 implants.ConclusionsThe behavior of osteoblasts depends on the type of implant and culture conditions. Ti SiO2 scaffolds sustain osteoblast adhesion and promote differentiation with increased collagen and non-collagenic proteins (OP and OC) production. Ti HA implants have a lower ability to induce cell adhesion and proliferation but an increased capacity to induce early mineralization. Addition of growth factors BMP-2 and TGFβ1 in differentiation medium did not improve the mineralization process. Both types of infiltrates have their advantages and limitations, which can be exploited depending on local conditions of bone lesions that have to be repaired. These limitations can also be offset through methods of functionalization with biomolecules involved in osteogenesis.

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Section: Discussionmentioning

confidence: 99%

Comparative in vitro study regarding the biocompatibility of titanium-base composites infiltrated with hydroxyapatite or silicatitanate

et al. 2014

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“…One of the most explored techniques to form various morphologies of TiO 2 layers is electrochemical anodization of the metallic surface . Compared with conventional methods like plasma spray method sol–gel technique , heat treatment , or chemical treatment , the electrochemical method introduces major advantages. The oxide films fabricated by anodization not only show various surface morphologies , but also may contain valuable chemical species incorporated from the electrolyte, which can be more effective for bioactive calcium phosphate formation after being implanted in the human body .…”

Section: Introductionmentioning

confidence: 99%

Corrosion behavior of TiO₂‐coated Ti–6Al–7Nb surfaces obtained by anodic oxidation in sulfuric or acetic acid

Cotolan

Pop

Marconi

et al. 2014

Materials & Corrosion

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The morpho-structural and electrochemical properties of the oxide film formed on the implants surface play a decisive role for the bio-compatibility of titaniumbased prosthesis. The aim of the present work is to investigate and compare the corrosion behavior of titanium dioxide (TiO 2 ) coated Ti-6Al-7Nb prepared by anodic oxidation in two different electrolytes (1 M acetic acid (CH 3 COOH) and sulfuric acid (H 2 SO 4 ) solutions) and at two different oxidation potentials. The corrosion behavior of oxidized samples was investigated in Hank's simulated physiological solution, using cyclic polarization method and electrochemical impedance spectroscopy and the obtained results were compared with those recorded on bare Ti-6Al-7Nb in the same experimental conditions. The oxidation in CH 3 COOH was proven to be more beneficial for the corrosion resistance of Ti-6Al-7Nb samples than the oxidation in H 2 SO 4 of same concentration.

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“…The first one occurs before 200°C, the second one between 200 and 330°C, the third one between 330 and 530°C, and the last one between 530 and 620°C. The first weight loss with an endothermic event around 100°C corresponds to the elimination of residual water and the dehydration of hydroxide hydrates in the precursors . The weight loss recorded in 180–350°C temperature range is likely related to the first step of decomposition and removal of residual nitrate groups from calcium nitrate used as precursor in the sol–gel synthesis process, as well as to pyrolysis of the residual organic component .…”

Section: Resultsmentioning

confidence: 99%

Molybdenum effect on the structure of SiO₂–CaO–P₂O₅ bioactive xerogels and on their interface processes with simulated biofluids

Ponta

Lucacel

Vulpoi

et al. 2013

J Biomedical Materials Res

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The study is focused on synthesis, investigation of the structural and morphological changes induced by MoO3 addition, and thermal treatment, as well as in vitro characterization of a new sol-gel derived SiO2-CaO-P2O5 bioactive materials. The obtained systems are composite materials consisting of nanocrystalline apatite, bioactive glass and CaMoO4 nanoparticles, which are of interest for both regenerative medicine and specific medical applications of the releasable molybdenum ions. The changes induced by the thermal treatments and MoO3 addition with respect to the structure and morphology were completed using differential thermal analysis\thermogravimetric analysis, X-ray diffraction (XRD), scanning electron microscopy (SEM), energy dispersive X-ray (EDX), X-ray photoelectron spectroscopy (XPS), Fourier transform infrared (FTIR) spectroscopy, electron paramagnetic resonance, and Brunauer-Emmett-Teller. The biological performance of these materials was evaluated in vitro by performing bioactivity and biocompatibility tests. The bioactive properties in terms of hydroxyapatite layer formation on the biomaterial surface after simulated body fluid immersion were studied by XRD and SEM. To establish their biocompatibility, the biomaterials surface was functionalized with protein and the resulted sample was investigated using SEM, FTIR, and XPS. The obtained results suggest that the addition of molybdenum oxide in proper concentration improves the biocompatibility in terms of enhancement of protein adherence on Si-Ca-P surface due to CaMoO4 crystalline phase development and does not inhibit bioactivity.

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Structural and surface characterization of nanostructured spray dried titanosilicate microspheres

Cited by 10 publications

References 37 publications

Comparative in vitro study regarding the biocompatibility of titanium-base composites infiltrated with hydroxyapatite or silicatitanate

Comparative in vitro study regarding the biocompatibility of titanium-base composites infiltrated with hydroxyapatite or silicatitanate

Corrosion behavior of TiO₂‐coated Ti–6Al–7Nb surfaces obtained by anodic oxidation in sulfuric or acetic acid

Molybdenum effect on the structure of SiO₂–CaO–P₂O₅ bioactive xerogels and on their interface processes with simulated biofluids

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Structural and surface characterization of nanostructured spray dried titanosilicate microspheres

Cited by 10 publications

References 37 publications

Comparative in vitro study regarding the biocompatibility of titanium-base composites infiltrated with hydroxyapatite or silicatitanate

Comparative in vitro study regarding the biocompatibility of titanium-base composites infiltrated with hydroxyapatite or silicatitanate

Corrosion behavior of TiO2‐coated Ti–6Al–7Nb surfaces obtained by anodic oxidation in sulfuric or acetic acid

Molybdenum effect on the structure of SiO2–CaO–P2O5 bioactive xerogels and on their interface processes with simulated biofluids

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Product

Resources

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Corrosion behavior of TiO₂‐coated Ti–6Al–7Nb surfaces obtained by anodic oxidation in sulfuric or acetic acid

Molybdenum effect on the structure of SiO₂–CaO–P₂O₅ bioactive xerogels and on their interface processes with simulated biofluids