Structural and temporal dynamics analysis of zinc-based biomaterials: History, research hotspots and emerging trends

Yuan, Kunshan; Deng, Chengchen; Tan, Lili; Wang, Xiangxiu; Yan, Wenhua; Dai, Xiaozhen; Du, Ruolin; Zheng, Yufeng; Zhang, Haijun; Wang, Guixue

doi:10.1016/j.bioactmat.2024.01.017

Cited by 4 publications

(1 citation statement)

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“…Insufficient vascularization is still a great challenge in the regeneration of critical-sized bone tissue defects ( Takaoka et al, 2024 ; Yuan et al, 2024 ). The formation of the H-type vessel plays a key role in the progress.…”

Section: Application Of Endogenous Stimulus-responsive In S...mentioning

confidence: 99%

Smart responsive in situ hydrogel systems applied in bone tissue engineering

Wu,

Gai,

Chen

et al. 2024

Front. Bioeng. Biotechnol.

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The repair of irregular bone tissue suffers severe clinical problems due to the scarcity of an appropriate therapeutic carrier that can match dynamic and complex bone damage. Fortunately, stimuli-responsive in situ hydrogel systems that are triggered by a special microenvironment could be an ideal method of regenerating bone tissue because of the injectability, in situ gelatin, and spatiotemporally tunable drug release. Herein, we introduce the two main stimulus-response approaches, exogenous and endogenous, to forming in situ hydrogels in bone tissue engineering. First, we summarize specific and distinct responses to an extensive range of external stimuli (e.g., ultraviolet, near-infrared, ultrasound, etc.) to form in situ hydrogels created from biocompatible materials modified by various functional groups or hybrid functional nanoparticles. Furthermore, “smart” hydrogels, which respond to endogenous physiological or environmental stimuli (e.g., temperature, pH, enzyme, etc.), can achieve in situ gelation by one injection in vivo without additional intervention. Moreover, the mild chemistry response-mediated in situ hydrogel systems also offer fascinating prospects in bone tissue engineering, such as a Diels–Alder, Michael addition, thiol-Michael addition, and Schiff reactions, etc. The recent developments and challenges of various smart in situ hydrogels and their application to drug administration and bone tissue engineering are discussed in this review. It is anticipated that advanced strategies and innovative ideas of in situ hydrogels will be exploited in the clinical field and increase the quality of life for patients with bone damage.

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Section: Application Of Endogenous Stimulus-responsive In S...mentioning

confidence: 99%

Smart responsive in situ hydrogel systems applied in bone tissue engineering

Wu,

Gai,

Chen

et al. 2024

Front. Bioeng. Biotechnol.

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Synergistic Role of Green‐Synthesized Zinc Oxide Nanomaterials in Biomedicine Applications

Muhammad Salman Ajmal,

Muneer,

Saeed

et al. 2024

ChemistrySelect

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The substantial impact of nanotechnology on material sciences is exemplified through zinc oxide nanomaterials (ZnO NMs), which play a pivotal role in healthcare and environmental applications. This comprehensive review focuses on the eco‐friendly synthesis of ZnO NMs and their cutting‐edge practices in biomedical, including drug delivery, bioimaging, and anticancer therapies. Exploring environmentally responsible production techniques for ZnO NMs aims to mitigate risks associated with conventional methods, such as the use of costly and toxic precursors. In addition, these green methodologies present opportunities for generating diverse and significant morphologies. The study delves into the inhibitory effects of these NMs against microbes, cancer, and inflammation. The utilization of ZnO NMs in disease treatment and diagnosis prompts us to explore recent developments in emerging biomedical applications. Leveraging ZnO variable optical characteristics, biodegradability, inherent biocompatibility, adaptable surface chemistry, and high stability, the review covers a range of remarkable research studies for novel applications that possibly open up the potential for identifying, treating, and preventing serious human diseases.

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