Structural and thermal analyses of metaxalone cocrystals with succinic, adipic and salicylic acids

Rajendrakumar, Satyasree; Sivanarayan, Palani; Sridhar, Balasubramanian

doi:10.1016/j.molstruc.2023.135019

Journal of Molecular Structure

2023

DOI: 10.1016/j.molstruc.2023.135019

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Structural and thermal analyses of metaxalone cocrystals with succinic, adipic and salicylic acids

Satyasree Rajendrakumar

Palani Sivanarayan

Balasubramanian Sridhar

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2024

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Cited by 1 publication

References 29 publications

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Preparation and Solid-State Characterization of Ketoprofen-Succinic Acid-Saccharin Co-Crystal With Improved Solubility

IMANTO,

WIKANTYASNING,

NURWAINI

et al. 2024

Int J App Pharm

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Objective: This study aimed to improve the solubility of Ketoprofen, a non-steroidal anti-inflammatory drug (NSAID) that belongs to the Biopharmaceutical Classification System (BCS) Class II, through co-crystallization using succinic acid and saccharin coformers in a 1:1:1 and 2:1:1 molar ratio. Methods: The slurry method was utilized to prepare the ketoprofen co-crystals, which were then subjected to various physical-chemical characterization techniques such as melting point determination, dissolution studies, differential scanning calorimetry (DSC), X-ray diffraction (XRD), and Fourier transform infrared (FTIR) spectroscopy. Results: The results showed that the 1:1:1 molar ratio of ketoprofen-succinic acid-saccharin co-crystal (Formula 1) exhibited higher solubility than the solubility standard of Ketoprofen and the 2:1:1 molar ratio of the co-crystal (Formula 2). The dissolution profile (Q30) of Formula 1, Formula 2, and standard Ketoprofen were 96.73±1.77, 93.09±1.16, and 70.22±4.72, respectively. These findings suggest that co-crystallization with succinic acid and saccharin conformers using the slurry method can significantly enhance the solubility of Ketoprofen. Conclusion: The 1:1:1 molar ratio of ketoprofen-succinic acid-saccharin co-crystal (Formula 1) was the most effective formulation among the tested samples, demonstrating the highest solubility. This research may provide valuable insights for developing novel drug formulations with improved bioavailability and therapeutic efficacy.

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Preparation and Solid-State Characterization of Ketoprofen-Succinic Acid-Saccharin Co-Crystal With Improved Solubility

IMANTO,

WIKANTYASNING,

NURWAINI

et al. 2024

Int J App Pharm

View full text Add to dashboard Cite

show abstract

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Structural and thermal analyses of metaxalone cocrystals with succinic, adipic and salicylic acids

Cited by 1 publication

References 29 publications

Preparation and Solid-State Characterization of Ketoprofen-Succinic Acid-Saccharin Co-Crystal With Improved Solubility

Preparation and Solid-State Characterization of Ketoprofen-Succinic Acid-Saccharin Co-Crystal With Improved Solubility

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