Structural and Thermal Analysis of Cannabidiol Orodispersible Formulations

Abstract

Cannabidiol (CBD) is an alkaloid that can be found in the Cannabis species, currently used in United States of America under the name of Epidiolex ® , which was approved by Food and Drug Administration (FDA) for seizures treatment. The purpose of this study was to investigate the structural characteristics of the raw materials and to compare 2 film formulations with different analytical methods. In order to differentiate the structural properties, the following methods were used: X-ray powder diffraction (XRPD) and Fourier transform-infrared (FTIR) spectroscopy. The thermal properties of the raw materials and films was also obtained using differential scanning calorimetry (DSC) and thermogravimetry analysis (TGA). As in the case of structural properties for the thermal decomposition, two films formulations that presented the highest differences were selected. Thermal analysis, FTIR and XRPD were utilized to present the characteristics of the raw materials and the selected orodispersible films. RezumatCanabidiolul (CBD) este unul din alcaloizii ce se regăsește în speciile de Cannabis. Ca produs medicamentos este prezent în Statele Unite ale Americii sub denumirea comercială de Epidiolex ® (medicament aprobat de Food and Drug Administration -FDA) pentru tratamentul epilepsiei. Scopul acestui studiu constă în prezentarea caracteristicilor structurale ale excipienților, substanței active, respectiv compararea a două formulări de filme orodispersabile prin metode analitice diferite. Pentru a pune în evidență proprietățile structurale ale formularilor s-au folosit următoarele metode: difracția de raze X și spectrometria în infraroșu cu transformată Fourier. Proprietățile termice ale excipienților, substanței active precum și cele ale filmelor au fost analizate utilizând calorimetria cu scanare diferențială și analiza termogravimetrică. La fel ca în cazul analizei proprietăților structurale, și în cazul analizei termice au fost selectate două formulări de filme ce au prezentat proprietăți distincte. FTIR și XRPD au fost utilizate pentru a evidenția proprietățile structurale, cele termice fiind evaluate utilizând DSC și ATG.

Stability, biofunctional, and antimicrobial characteristics of cannabidiol isolate for the design of topical formulations

“…The initiation of degradation was observed above 140 °C, which is in line with the TGA observations. The DSC endothermic peak at 68.97 °C for CBD-IS was also observed by Andriotis et al 21 and Vlad et al 22 According to the authors, CBD-IS decomposition might occur at temperatures higher than 300 °C. The melting of CBD-IS powder was measured to be 68.6 ± 0.2 °C which substantiated the TGA and DSC observations.…”

Experimental Solubility of Cannabidiol (CBD) in Different Organic Solvents

“…As shown, our experimental values are numerically close to those from previous studies, indicating the accuracy of the DSC method. The differences might be related to the sample purity, though this is reported in only one of the previous works (ref ).…”

“…Previous works have also studied the melting point and the enthalpy of fusion of CBD with DSC analysis, − reporting values in the range of 67.5–71.3 °C and 19–28 kJ mol –1 , respectively. A comparison of the thermal analysis data for CBD that were collected in this study and those reported in previous works is provided in Table .…”

“…As shown, our experimental values are numerically close to those from previous studies, indicating the accuracy of the DSC method. The differences might be related to the sample purity, though this is reported in only one of the previous works (ref 32). In this work, CBD exhibited only one thermal transition, and the endotherm peak corresponded to the melting of the crystals.…”

Development and Characterization of the Novel Cannabidiol Loaded Polycaprolactone Nanoparticles to Boost the Bioavailability in Medicinal Oral Supplements

“…Characteristic bands of CBD were identi ed at 3518 cm -1 , 3404 cm -1 , 1628 cm -1 , and 1585 cm -1 [21]. In the FT-IR spectrum of CBD, the prominent bands in the range of 3404 cm -1 to 3518 cm -1 corresponded to O-H stretching vibrations, while the bands at 3074 cm -1 represented C-H stretching (phenyl), the band at 2924 cm -1 indicated methyl and methylene groups, the band at 1585 cm -1 represented C = C stretching in the phenyl ring, and C-O stretching vibrations were observed at 1213 cm -1 [22].…”