Structural, antioxidant, and emulsifying activities of fucoidan from Saccharina japonica using pressurized liquid extraction

Saravana, Periaswamy Sivagnanam; Cho, Yeon-Jin; Park, Yong Bum; Woo, Hee-Chul; Chun, Byung‐Soo

doi:10.1016/j.carbpol.2016.08.014

Cited by 152 publications

(85 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Fucoidan demonstrated good antioxidant and emulsifying activities were extracted from brown seaweed Saccharina japonica [99] and frequency of the microwave, extraction time, concentration of solvent, characteristics of the matrix, ratio of solid to liquid, extraction pressure, number of extraction cycles, and most importantly properties of the solvents and temperature [82,101]. MAE has a number of advantages, such as shorter extraction time, less solvent, higher extraction rate and lower cost, over traditional method of extraction of compounds from various matrices, especially natural products and large scale samples [104,105].…”

Section: Microwave-assisted Extraction (Mae)mentioning

confidence: 99%

“…Then, only recently, Saravana et al [99] managed to extracted sulphated polysaccharides (fucoidan) from brown seaweed Saccharina japonica (Table 5). They found that the best crude fucoidan with excellent emulsion-stabilizing and antioxidant capacities were obtained from temperature (140°C) and pressure (50 bars) with sodium hydroxide (NaOH) using PSE method.…”

Section: Pressurized Solvent Extraction (Pse)mentioning

confidence: 99%

See 1 more Smart Citation

A review of extractions of seaweed hydrocolloids: Properties and applications

Khalil¹,

Lai²,

Tye³

et al. 2018

Express Polym. Lett.

151

View full text Add to dashboard Cite

Section: Microwave-assisted Extraction (Mae)mentioning

confidence: 99%

Section: Pressurized Solvent Extraction (Pse)mentioning

confidence: 99%

A review of extractions of seaweed hydrocolloids: Properties and applications

Khalil¹,

Lai²,

Tye³

et al. 2018

Express Polym. Lett.

151

View full text Add to dashboard Cite

“…However, the production rate of fucoidan is low. Therefore, enzyme- [5], microwave- [6], and ultrasound-assisted extraction methods [7] and pressurized liquid extraction were developed [8]. According to different extraction methods, the molecular weight of fucoidan products can range from 20,000 to 200,000 daltons or from 400 to 5000 daltons, which is called low-molecular-weight fucoidan (LMF) [9].…”

Section: Introductionmentioning

confidence: 99%

Efficacy of Low-Molecular-Weight Fucoidan as a Supplemental Therapy in Metastatic Colorectal Cancer Patients: A Double-Blind Randomized Controlled Trial

et al. 2017

View full text Add to dashboard Cite

Background: Low-molecular-weight fucoidan (LMF) is widely used as a food supplement for cancer patients. However, all of the studies are in vitro or were conducted using mice. Therefore, powerful clinical evidence for LMF use is relatively weak. This study aimed to evaluate the efficacy of LMF as a supplemental therapy to chemo-target agents in metastatic colorectal cancer (mCRC) patients. Methods: We conducted a prospective, randomized, double-blind, controlled trial to evaluate the efficacy of LMF as a supplemental therapy to chemotarget agents in patients with metastatic colorectal cancer (mCRC). Sixty eligible patients with mCRC were included. Finally, 54 patients were enrolled, of whom 28 were included in the study group and 26 in the control group. The primary endpoint was the disease control rate (DCR), and secondary endpoints included the overall response rate (ORR), progression-free survival (PFS), overall survival (OS), adverse effects (AEs), and quality of life (QOL). Results: The DCRs were 92.8% and 69.2% in the study and control groups, respectively (p = 0.026), in a median follow-up period of 11.5 months. The OS, PFS, ORR, AEs, and QOL did not significantly differ between the two groups. Conclusion: This is the first clinical trial evaluating the efficacy of LMF as a supplemental therapy in the management of patients with mCRC. The results indicate that LMF combined with chemotarget agents significantly improved the DCR.

show abstract

“…However carrageenan included in cosmetic products was not reported to induce adverse effects on human skin . Crude extracts containing sulphated polysaccharides obtained from brown seaweeds (fucoidan) were shown to display promising emulsifying properties due to their protein content and mild amphiphilic character provided by the presence of methyl groups along their polymeric backbone . Ulvan, a sulphated heteropolysaccharide extracted from edible green algae belonging to the genus Ulva , shares similar structural properties with fucoidan, hence potentially resulting in an innovative emulsifying agent of natural origin.…”

Section: Introductionmentioning

confidence: 99%

Development of ulvan‐based emulsions containing flavour and fragrances for food and cosmetic applications

Morelli

Massironi

Puppi

et al. 2019

Flavour & Fragrance J

View full text Add to dashboard Cite

In the present work, ulvan, a sulphated polysaccharide of algal origin, was innovatively investigated as stabilizing and emulsifying agent in colloidal formulations containing functional agents for food and cosmetic applications in virtue of its edibility and amphiphilic character. Ulvan was successfully submitted to chemical modification with biocompatible fatty acid moieties to increase the amphiphilic properties of the polysaccharide without compromising its safety profile. Oil in water (O/W) emulsions were developed using the ultrasonication method as an easy and rapid homogenization process. The stability of the obtained formulations was assessed by visual inspection, size distribution and zeta potential analysis. Stable emulsions were obtained by using either native or chemically modified polysaccharide. The most promising formulations based on the use of native ulvan were successfully implemented as clouding and flavouring agents in soft drink beverages and as stabilizing and perfuming agents in body cream milk products. The obtained results may open new perspectives on the exploitation of abundant waste biomasses as sources of biocompatible high value added materials suitable for being applied in critical applications as a safe alternative to synthetic chemicals. In particular ulvan could represent a valuable platform of functional and bioactive compounds with promising properties as stabilizing and emulsifying agents for food and cosmetic applications.

show abstract

Structural, antioxidant, and emulsifying activities of fucoidan from Saccharina japonica using pressurized liquid extraction

Cited by 152 publications

References 38 publications

A review of extractions of seaweed hydrocolloids: Properties and applications

A review of extractions of seaweed hydrocolloids: Properties and applications

Efficacy of Low-Molecular-Weight Fucoidan as a Supplemental Therapy in Metastatic Colorectal Cancer Patients: A Double-Blind Randomized Controlled Trial

Development of ulvan‐based emulsions containing flavour and fragrances for food and cosmetic applications

Contact Info

Product

Resources

About