2024
DOI: 10.1073/pnas.2320388121
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Structural basis for EROS binding to human phagocyte NADPH oxidase NOX2

Shiyu Liang,
Aijun Liu,
Yezhou Liu
et al.

Abstract: Essential for reactive oxygen species (EROS) protein is a recently identified molecular chaperone of NOX2 (gp91 phox ), the catalytic subunit of phagocyte NADPH oxidase. Deficiency in EROS is a recently identified cause for chronic granulomatous disease, a genetic disorder with recurrent bacterial and fungal infections. Here, we report a cryo-EM structure of the EROS–NOX2–p22 phox heterotrimeric complex at an overall resolution of 3.56Å. EROS and p22 … Show more

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