“…The myosin motor is thus subject to substantial conformational changes along that cycle, traversing through different actin-attached and –detached states, eventually amplifying them to a large scale rotation of the converter domain and swinging of the adjacent lever arm in the force-generating power stroke [ 10 ]. Many of the subprocesses have been extensively studied in the past, and newly observed conformations, obtained through cryo-electron microscopy (cryoEM) [ 11 , 12 , 13 ] or crystallization with native and artificial ligands [ 14 , 15 , 16 , 17 ] that trapped myosin in a specific state, have been assigned as states of the actomyosin cycle according to the status of the characteristic structural elements in the myosin motor domain, thus building the basis for the motor function. Numerous studies have significantly contributed to our understanding of the mechanism of the recovery stroke [ 18 , 19 , 20 , 21 , 22 , 23 ], which primes the myosin motor for force production while dissociated from the actin filament.…”