2014
DOI: 10.1080/07391102.2014.899924
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Structural basis ofBacillus anthracisMoxXT disruption and the modulation of MoxT ribonuclease activity by rationally designed peptides

Abstract: Bacillus anthracis MoxXT is a Type II proteic Toxin-Antitoxin (TA) module wherein MoxT is a ribonuclease that cleaves RNA specifically while MoxX interacts with MoxT and inhibits its activity. Disruption of the TA interaction has been proposed as a novel antibacterial strategy. Peptides, either based on antitoxin sequence or rationally designed, have previously been reported to disrupt the MoxXT interaction but cause a decrease in MoxT ribonuclease activity. In the present study, we report the crystal structur… Show more

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Cited by 12 publications
(25 citation statements)
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“…This region corresponds to an area called Site 1 (Fig. 4), which was named in previous MazF studies (30,33). This agrees well with the E. coli EDF and EDF-like peptide docking studies performed on E. coli MazF and B. anthracis MoxT (26,33).…”
Section: Biological Implication Of M Tuberculosis Mazf4 Activity Enhsupporting
confidence: 88%
See 4 more Smart Citations
“…This region corresponds to an area called Site 1 (Fig. 4), which was named in previous MazF studies (30,33). This agrees well with the E. coli EDF and EDF-like peptide docking studies performed on E. coli MazF and B. anthracis MoxT (26,33).…”
Section: Biological Implication Of M Tuberculosis Mazf4 Activity Enhsupporting
confidence: 88%
“…4), which was named in previous MazF studies (30,33). This agrees well with the E. coli EDF and EDF-like peptide docking studies performed on E. coli MazF and B. anthracis MoxT (26,33). In the peptide docking model of MoxT, the opening of the S1-S2 loop is required for peptide binding at the bottom of the S1-S2 loop of MoxT, as the area is buried under the S1-S2 loop (33).…”
Section: Biological Implication Of M Tuberculosis Mazf4 Activity Enhsupporting
confidence: 88%
See 3 more Smart Citations