Structural brain abnormalities in adolescents and young adults with congenital heart defect: a systematic review

Bolduc, Marie-Ève; Lambert, Heather C.; Ganeshamoorthy, Sylviya; Brossard‐Racine, Marie

doi:10.1111/dmcn.13975

Cited by 39 publications

(35 citation statements)

References 49 publications

(372 reference statements)

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“…T A B L E 3 Total and regional brain volumes differences between CHD and controls The hippocampal alterations reported in our study were not associated with the presence of brain abnormalities as detected by conventional MRI. Mild brain abnormalities were detected in 24% of the CHD group which is consistent with previous studies performed in similar cohorts (Bolduc et al, 2018). Per their nature, the observed brain abnormalities in our cohort are thought to be sequelae of early life injury in neonates with CHD.…”

Section: Discussionsupporting

confidence: 92%

“…Mild brain abnormalities were detected in 24% of the CHD group which is consistent with previous studies performed in similar cohorts (Bolduc et al, 2018). Mild brain abnormalities were detected in 24% of the CHD group which is consistent with previous studies performed in similar cohorts (Bolduc et al, 2018).…”

Section: Discussionsupporting

confidence: 91%

“…The brains of individuals with CHD are at high risk for injury from the cumulative effect of hemodynamic stress and brain dysmaturation that occur in utero to the high risk for hypoxic-ischemia during the pre-, intra-, and post-operative periods (Andropoulos et al, 2010;Brossard-Racine et al, 2014;Dimitropoulos et al, 2013;. A recent meta-analysis concluded that youth with CHD were 15.6 times more likely to present with a brain abnormality (based on neuroimaging findings) compared to healthy controls (Bolduc, Lambert, Ganeshamoorthy, & Brossard-Racine, 2018). We have yet to understand whether the multiple early life risk factors have a persisting impact on their brain morphology 15-20 years after their open heart surgery.…”

Section: Introductionmentioning

confidence: 99%

“…We have yet to understand whether the multiple early life risk factors have a persisting impact on their brain morphology 15-20 years after their open heart surgery. A recent meta-analysis concluded that youth with CHD were 15.6 times more likely to present with a brain abnormality (based on neuroimaging findings) compared to healthy controls (Bolduc, Lambert, Ganeshamoorthy, & Brossard-Racine, 2018). Even in the absence of brain abnormalities seen on conventional magnetic resonance images (MRI), many youths with CHD presented with worse neurocognitive outcomes when compared to healthy peers (von Rhein et al, 2014).…”

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confidence: 99%

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Hippocampal alterations and functional correlates in adolescents and young adults with congenital heart disease

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Rohlicek

Saint‐Martin

et al. 2019

Human Brain Mapping

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There is a high prevalence of neurodevelopmental impairments in individuals living with congenital heart disease (CHD) and the neural correlates of these impairments are not yet fully understood. Recent studies have shown that hippocampal volume and shape differences may provide unique biomarkers for neurodevelopmental disorders. The hippocampus is vulnerable to early life injury, especially in populations at risk for hypoxemia or hemodynamic instability such as in neonates with CHD. We compared hippocampal gray and white matter volume and morphometry between youth born with CHD (n = 50) aged 16–24 years and healthy peers (n = 48). We also explored whether hippocampal gray and white matter volume and morphometry are associated with executive function and self‐regulation deficits. To do so, participants underwent 3T brain magnetic resonance imaging and completed the self‐reported Behavior Rating Inventory of Executive Function—Adult version. We found that youth with CHD had smaller hippocampal volumes (all statistics corrected for false discovery rate; q < 0.05) as compared to controls. We also observed significant smaller surface area bilaterally and inward displacement on the left hippocampus predominantly on the ventral side (q < 0.10) in the CHD group that were not present in the controls. Left CA1 and CA2/3 were negatively associated with working memory (p < .05). Here, we report, for the first‐time, hippocampal morphometric alterations in youth born with CHD when compared to healthy peers, as well as, structure–function relationships between hippocampal volumes and executive function. These differences may reflect long lasting alterations in brain development specific to individual with CHD.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 91%

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

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Hippocampal alterations and functional correlates in adolescents and young adults with congenital heart disease

Fontes

Rohlicek

Saint‐Martin

et al. 2019

Human Brain Mapping

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“…In the article by Bolduc et al., the odds ratio given in the results section of the abstract was incorrect. It should have been 41.7.…”

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confidence: 99%

Corrigendum

2019

Develop Med Child Neuro

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Academic achievement and needs of school‐aged children born with selected congenital anomalies: A systematic review and meta‐analysis

Glinianaia

McLean

Moffat

et al. 2021

Birth Defects Research

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Children with congenital anomalies have poorer intellectual and cognitive development compared to their peers, but evidence for academic achievement using objective measures is lacking. We aimed to summarize and synthesize evidence on academic outcomes and special education needs (SEN) of school-aged children born with selected major structural congenital anomalies. Electronic databases (MEDLINE, EMBASE, Scopus, PsycINFO, CINAHL, ProQuest Natural Science and Education Collections), reference lists and citations for 1990-2020 were systematically searched. We included original-research articles on academic achievement in children with non-syndromic congenital anomalies that involved school test results, standardized tests and/or SEN data. Randomeffects meta-analyses were performed to estimate pooled mean test scores in mathematics and/or reading where possible and pooled odds ratios (ORs) for SEN in children with severe congenital heart defects (CHDs) and children with orofacial clefts (OFCs). Thirty-nine eligible studies (n = 21,066 children) were synthesized narratively. Sixteen studies were included in meta-analyses. Children with non-syndromic congenital anomalies were at a higher risk of academic underachievement than controls across school levels. Children with severe CHD (pooled OR = 2.32, 95% CI: 1.90, 2.82), and children with OFC (OR = 1.38 (95% CI: 1.20, 1.57), OR = 3.07 (95% CI: 2.65, 3.56), and OR = 3.96 (95% CI: 3.31, 4.72) for children with cleft lip, cleft palate and cleft lip/palate, respectively) had significantly higher ORs for SEN than controls. Children with non-syndromic congenital anomalies underperform academically and have higher SEN rates compared to their peers. Early monitoring and development of differential SEN are important to promote academic progress in these children.

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Structural brain abnormalities in adolescents and young adults with congenital heart defect: a systematic review

Cited by 39 publications

References 49 publications

Hippocampal alterations and functional correlates in adolescents and young adults with congenital heart disease

Hippocampal alterations and functional correlates in adolescents and young adults with congenital heart disease

Corrigendum

Academic achievement and needs of school‐aged children born with selected congenital anomalies: A systematic review and meta‐analysis

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