Structural Brain Alterations in Community Dwelling Individuals with Chronic Joint Pain

Kruijf, Marjolein de; Bos, Daniël; Huygen, Frank; Niessen, Wiro J.; Tiemeier, Henning; Hofman, Albert; Uitterlinden, A.G.; Vernooij, Meike W.; Ikram, M. Arfan; Meurs, Joyce B. J. van

doi:10.3174/ajnr.a4556

Cited by 21 publications

(27 citation statements)

References 52 publications

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“…Previous studies have indicated that chronic pain can induce volume changes in the brain (May, 2008; Kregel et al, 2015; de Kruijf et al, 2016). The brain gray matter is closely associated with the body’s pain perception (Cauda et al, 2014; Emerson et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

Microstructural Abnormalities Were Found in Brain Gray Matter from Patients with Chronic Myofascial Pain

et al. 2016

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Myofascial pain, presented as myofascial trigger points (MTrPs)-related pain, is a common, chronic disease involving skeletal muscle, but its underlying mechanisms have been poorly understood. Previous studies have revealed that chronic pain can induce microstructural abnormalities in the cerebral gray matter. However, it remains unclear whether the brain gray matters of patients with chronic MTrPs-related pain undergo alteration. In this study, we employed the Diffusion Kurtosis Imaging (DKI) technique, which is particularly sensitive to brain microstructural perturbation, to monitor the MTrPs-related microstructural alterations in brain gray matter of patients with chronic pain. Our results revealed that, in comparison with the healthy controls, patients with chronic myofascial pain exhibited microstructural abnormalities in the cerebral gray matter and these lesions were mainly distributed in the limbic system and the brain areas involved in the pain matrix. In addition, we showed that microstructural abnormalities in the right anterior cingulate cortex (ACC) and medial prefrontal cortex (mPFC) had a significant negative correlation with the course of disease and pain intensity. The results of this study demonstrated for the first time that there are microstructural abnormalities in the brain gray matter of patients with MTrPs-related chronic pain. Our findings may provide new insights into the future development of appropriate therapeutic strategies to this disease.

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Section: Introductionmentioning

confidence: 99%

Microstructural Abnormalities Were Found in Brain Gray Matter from Patients with Chronic Myofascial Pain

et al. 2016

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“…In our study, two-third of the subjects with daily chronic pain were females; comorbid daily chronic pain and chronic cough were also more prevalent in females. DE KRUIJF et al [30] found that females with chronic pain have smaller total gray matter volume suggesting sex-specific changes in the brain in response to chronic pain.…”

Section: Discussionmentioning

confidence: 99%

The interrelatedness of chronic cough and chronic pain

et al. 2020

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BackgroundSince chronic cough has common neurobiological mechanisms and pathophysiology with chronic pain, both clinical disorders might be interrelated. Hence, we examined the association between chronic cough and chronic pain in adult subjects in the Rotterdam Study, a large prospective population-based cohort study.MethodsUsing a standardised questionnaire, chronic pain was defined as pain lasting up to 6 months and grouped into a frequency of weekly/monthly or daily pain. Chronic cough was described as daily coughing for at least 3 months duration. The longitudinal and cross-sectional associations were investigated bi-directionally.ResultsOf 7141 subjects in the study, 54% (n=3888) reported chronic pain at baseline. The co-prevalence of daily chronic pain and chronic cough was 4.4%. Chronic cough was more prevalent in subjects with daily and weekly/monthly chronic pain compared with those without chronic pain (13.8% and 10.3% versus 8.2%, p<0.001). After adjustment for potential confounders, prevalent chronic pain was significantly associated with incident chronic cough (OR 1.47, 95% CI 1.08–1.99). The association remained significant in subjects with daily chronic pain (OR 1.49, 95% CI 1.06–2.11) with a similar effect estimate, albeit non-significant, in those with weekly/monthly chronic pain (OR 1.43, 95% CI 0.98–2.10). After adjustment for covariables, subjects with chronic cough had a significant risk of developing chronic pain (OR 1.63, 95% CI 1.02–2.62) compared with those without chronic cough.ConclusionChronic cough and chronic pain confer risk on each other among adult subjects, indicating that both conditions might share common risk factors and/or pathophysiologic mechanisms.

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“…Grey matter volume of the temporal and frontal lobes and the hippocampus were found to be smaller in women with pain compared to those without pain, indicated involvement of emotional processing. The volumetric differences found indicated a sex-specific neuroplasticity in chronic pain [ 211 ]. Lower sex hormone levels were found to be associated with chronic musculoskeletal pain, independent from lifestyle and health-related factors in women, suggesting that sex hormones play a role in chronic pain and should be taken into account when a patient presents with chronic pain [ 212 ].…”

Section: Locomotor Diseasesmentioning

confidence: 99%

The Rotterdam Study: 2018 update on objectives, design and main results

et al. 2017

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The Rotterdam Study is a prospective cohort study ongoing since 1990 in the city of Rotterdam in The Netherlands. The study targets cardiovascular, endocrine, hepatic, neurological, ophthalmic, psychiatric, dermatological, otolaryngological, locomotor, and respiratory diseases. As of 2008, 14,926 subjects aged 45 years or over comprise the Rotterdam Study cohort. Since 2016, the cohort is being expanded by persons aged 40 years and over. The findings of the Rotterdam Study have been presented in over 1500 research articles and reports (see www.erasmus-epidemiology.nl/rotterdamstudy). This article gives the rationale of the study and its design. It also presents a summary of the major findings and an update of the objectives and methods.

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Structural Brain Alterations in Community Dwelling Individuals with Chronic Joint Pain

Cited by 21 publications

References 52 publications

Microstructural Abnormalities Were Found in Brain Gray Matter from Patients with Chronic Myofascial Pain

Microstructural Abnormalities Were Found in Brain Gray Matter from Patients with Chronic Myofascial Pain

The interrelatedness of chronic cough and chronic pain

The Rotterdam Study: 2018 update on objectives, design and main results

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