2023
DOI: 10.3389/fnagi.2023.1065191
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Structural brain signatures of frailty, defined as accumulation of self-reported health deficits in older adults

Abstract: BackgroundFrailty in older adults has been associated with reduced brain health. However, structural brain signatures of frailty remain understudied. Our aims were: (1) Explore associations between a frailty index (FI) and brain structure on magnetic resonance imaging (MRI). (2) Identify the most important FI features driving the associations.MethodsWe designed a cross-sectional observational study from a population-based study (The Irish Longitudinal Study on Aging: TILDA). Participants aged ≥50 years who und… Show more

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Cited by 2 publications
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References 42 publications
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