Structural brain splitting is a hallmark of Granulin-related frontotemporal dementia

Background and ObjectivesPathogenic variants in the GRN gene cause frontotemporal dementia (FTD-GRN) with marked brain asymmetry. This study aims to assess whether the disease progression of FTD-GRN depends on the initial side of the atrophy. We also investigated the potential use of brain asymmetry as a biomarker of the disease. MethodsRetrospective examination of data from the prospective Genetic Frontotemporal Initiative (GENFI) cohort study that recruits individuals who carry or were at risk of carrying a pathogenic variant causing FTD. GENFI participants underwent a standardized clinical and neuropsychological assessment, MRI, and a blood sample test yearly. We generated an asymmetry index for brain MRI to characterize brain asymmetry in participants with or at risk of FTD-GRN. Depending on the side of the asymmetry, we classified symptomatic GRN patients as

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Structural brain splitting is a hallmark of Granulin-related frontotemporal dementia

Cited by 2 publications

References 54 publications

The human functional connectome in neurodegenerative diseases: relationship to pathology and clinical progression

The human functional connectome in neurodegenerative diseases: relationship to pathology and clinical progression

Association of Initial Side of Brain Atrophy With Clinical Features and Disease Progression in Patients With GRN Frontotemporal Dementia

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