Structural Changes Associated with Delayed Dark Adaptation in Age-Related Macular Degeneration

Laíns, Inês; Miller, John B.; Park, Dong H.; Tsikata, Edem; Davoudi, Samaneh; Rahmani, Safa; Pierce, Jonathan L.; Silva, Rufino; Chen, Teresa C.; Kim, Ivana K.; Vavvas, Demetrios G.; Miller, Joan W.; Husain, Deeba

doi:10.1016/j.ophtha.2017.03.061

Cited by 64 publications

(74 citation statements)

References 60 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…30,31 On this basis, the 58 retinal eccentricity would seem a more logical choice for longitudinal evaluation of AMD than the 128 retinal location. However, this study and others 19,21,26 have demonstrated that the time taken for people with iAMD to reach the rod intercept in the 58 location is substantial and may exceed 20 minutes in a quarter or more of participants. Threshold measurement continues throughout this time, which is fatiguing for patients (a factor known to reduce performance in psychophysical tests 35 ), and is inconvenient and costly in terms of clinic time.…”

Section: Discussioncontrasting

confidence: 52%

“…44 Analysis of color fundus photographs and near-infrared images from the Rotterdam study cohort revealed a prevalence of 35% for individuals with soft drusen OR pigmentary changes, and 14.5% for those with soft drusen AND pigmentary changes. 45 In the current study, as there is substantial evidence to suggest that those with SDD will take longer to reach the rod intercept, 21,26 the composition of the group with respect to SDD status is likely to have had an impact on the performance characteristics under each test condition. Future studies employing a higher proportion of participants with SDD may find that the test conditions identified as optimal here require an unacceptably long recovery time, while the 58 location may provide a higher sensitivity to progression of disease-related changes in a group which has a lower proportion of participants with SDD than the current study.…”

Section: Assessing Dark Adaptation In People Withmentioning

confidence: 81%

“…It has been reported that the presence of any structural abnormality in the retinal testing spot is associated with a significantly prolonged RIT during dark adaptation assessment. 26 Thus, the variability is likely to reflect the topographical heterogeneity of the disease process in AMD, and the focal nature of the test stimulus used in this device. This variability in results was also high for the control group.…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Determining Optimal Test Parameters for Assessing Dark Adaptation in People With Intermediate Age-Related Macular Degeneration

Binns

Taylor

Edwards

et al. 2018

Invest. Ophthalmol. Vis. Sci.

View full text Add to dashboard Cite

Citation: Binns AM, Taylor DJ, Edwards LA, Crabb DP. Determining optimal test parameters for assessing dark adaptation in people with intermediate age-related macular degeneration. Invest Ophthalmol Vis Sci. 2018;59:AMD114-AMD121. https:// doi.org/10.1167/iovs.18-24211 PURPOSE. The primary aim was to determine optimal test conditions for evaluating dark adaptation in intermediate age-related macular degeneration (iAMD) in order to minimize test time while maintaining diagnostic sensitivity.METHODS. People with AMD and age-similar controls were recruited (aged >55 years). Rod intercept time (RIT) was assessed after a 76%, 70%, and 65% rhodopsin bleach at 58 eccentricity and 76% and 70% bleach at 128. Test order was randomized and a 30-minute washout period added between tests. Results were compared between control and iAMD groups and receiver operating characteristics (ROC) curves were constructed. RESULTS.A total of 26 participants with variable grades of macular health attended for two visits. There was a statistically significant difference in average RIT between the control and iAMD groups at 58 (median, IQR controls ¼ 5.8 minutes, 3.8-7.5; iAMD ¼ 20.6 minutes, 11.1-30.0; Mann-Whitney, P ¼ 0.01) and at 128 (mean, controls: 4.54 minutes 6 2.12 SD, iAMD ¼ 7.72 minutes 6 3.37 SD; independent samples t-test, P ¼ 0.03) following a 76% bleach. Area under the ROC curves was 0.83 (confidence interval [CI]: 0.64-1.0) and 0.79 (CI: 0.59-0.99) for these two test conditions, respectively. Five participants (45%) in the iAMD group had RITs >20 minutes for 76% bleach at 58, but none for any other test condition.CONCLUSIONS. Nearly half of the participants with iAMD produced unacceptably long recovery times (>20 minutes) using a 76% bleach at 58 eccentricity. The 76% bleach at 128 provided almost equivalent separation between AMD and controls but recovery was achieved within 20 minutes.

show abstract

Section: Discussioncontrasting

confidence: 52%

Section: Assessing Dark Adaptation In People Withmentioning

confidence: 81%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Determining Optimal Test Parameters for Assessing Dark Adaptation in People With Intermediate Age-Related Macular Degeneration

Binns

Taylor

Edwards

et al. 2018

Invest. Ophthalmol. Vis. Sci.

View full text Add to dashboard Cite

show abstract

“…Although this study examined static rod function, our findings are in agreement with those reported in previous studies where rod recovery was assessed. 19,26,27 In addition, we have further shown that static rod function of iAMD cases without SDD was indistinguishable from control cases when tested without photobleach. A difference in static rod function between iAMD without SDD and control group was only observed when tested with preceding photobleach.…”

Section: Discussionmentioning

confidence: 56%

“…Similarly, other high-risk features for progression, such as HF or nGA also failed to be associated with worse rod function in either iAMD group. Recently, Lains et al 27 reported a somewhat similar finding that abnormal rod function was associated with the presence of SDD anywhere in the macula. However, in the Lains et al study, 27 the rod intercept time was used to determine rod recovery function and it was tested only at one retinal location 58 superior to the fovea.…”

Section: Discussionmentioning

confidence: 80%

Subretinal Drusenoid Deposits and the Loss of Rod Function in Intermediate Age-Related Macular Degeneration

Tan

Guymer

Luu

2018

Invest. Ophthalmol. Vis. Sci.

View full text Add to dashboard Cite

METHODS. In this cross-sectional study, retinal sensitivities within the central 248 retina were obtained twice using a dark-adapted chromatic perimeter, both with 505-and 625-nm stimuli. Tests were performed after 30 minutes of dark-adaptation either with or without a preceding photobleach. Multimodal imaging was performed to grade AMD and SDD status, and other retinal changes considered being risk factors for progression to late AMD. The sensitivity difference between both stimuli was used to assess rod function. The average point wise sensitivity difference (PWSD) was compared among the study groups.RESULTS. Twenty-nine control subjects and 20 iAMD without SDD and 17 iAMD with SDD cases were recruited. The average PWSD of the SDD group was significantly reduced (more with photobleach) compared with that of the control (P < 0.001) and no-SDD groups (P < 0.001), but only within the central 88. The average PWSD of the non-SDD group was also reduced compared with the control group but only for measurements with photobleach (P ¼ 0.020). There was no difference in average PWSD between the presence and absence of hyperreflective foci and/or nascent geographic atrophy in iAMD eyes without SDD (P ¼ 0.60) or with SDD (P ¼ 0.12).CONCLUSIONS. iAMD eyes with SDD are associated with worse static rod function compared with eyes without SDD. The greatest abnormality in rods is observed within the central 88 and when tested with a preceding photobleach.

show abstract

Current Management of Age-Related Macular Degeneration

Ung

Miller

Kim

2021

Advances in Experimental Medicine and Biology

View full text Add to dashboard Cite

Structural Changes Associated with Delayed Dark Adaptation in Age-Related Macular Degeneration

Cited by 64 publications

References 60 publications

Determining Optimal Test Parameters for Assessing Dark Adaptation in People With Intermediate Age-Related Macular Degeneration

Determining Optimal Test Parameters for Assessing Dark Adaptation in People With Intermediate Age-Related Macular Degeneration

Subretinal Drusenoid Deposits and the Loss of Rod Function in Intermediate Age-Related Macular Degeneration

Current Management of Age-Related Macular Degeneration

Contact Info

Product

Resources

About