Structural changes in human brain tissue during prenatal alcoholization at different stages of intrauterine development

Solonsky, A V; Shumilova, S N; Potapov, A. V.; Логвинов, С. В.; Махмутходжаев, А. Ш.; Zhdankina, A. A.; Бохан, Н. А.

doi:10.17116/jnevro2023123061100

Cited by 1 publication

(1 citation statement)

References 19 publications

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“…The prenatal development of the mammalian brain consists of four stages [28]: the first stage, the generation of precursor cells from stem cells; the second stage, the migration of precursor cells to the target brain region; the third stage, the differentiation of new neurons into mature synaptic active cells; and the fourth stage, the pruning of new neurons via apoptosis. Therefore, factors that influence brain migration and differentiation in mammals play an important role in adult neurogenesis.…”

Section: The Regulatory Role Of Wnt/β-catenin In Adult Neurogenesismentioning

confidence: 99%

Curcumin Improves Neurogenesis in Alzheimer’s Disease Mice via the Upregulation of Wnt/β-Catenin and BDNF

Lou,

Gong,

Yang

et al. 2024

IJMS

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Adult neurogenesis in the dentate gyrus (DG) is impaired during Alzheimer’s disease (AD) progression. Curcumin has been reported to reduce cell apoptosis and stimulate neurogenesis. This study aimed to investigate the influence of curcumin on adult neurogenesis in AD mice and its potential mechanism. Two-month-old male C57BL/6J mice were injected with soluble β-amyloid (Aβ1–42) using lateral ventricle stereolocalization to establish AD models. An immunofluorescence assay, including bromodeoxyuridine (BrdU), doublecortin (DCX), and neuron-specific nuclear antigen (NeuN), was used to detect hippocampal neurogenesis. Western blot and an enzyme-linked immunosorbent assay (ELISA) were used to test the expression of related proteins and the secretion of brain-derived neurotrophic factor (BDNF). A Morris water maze was used to detect the cognitive function of the mice. Our results showed that curcumin administration (100 mg/kg) rescued the impaired neurogenesis of Aβ1–42 mice, shown as enhanced BrdU+/DCX+ and BrdU+/NeuN+ cells in DG. In addition, curcumin regulated the phosphatidylinositol 3 kinase (PI3K)/protein kinase B (Akt) -mediated glycogen synthase kinase-3β (GSK3β) /Wingless/Integrated (Wnt)/β-catenin pathway and cyclic adenosine monophosphate response element-binding protein (CREB)/BDNF in Aβ1–42 mice. Inhibiting Wnt/β-catenin and depriving BDNF could reverse both the upregulated neurogenesis and cognitive function of curcumin-treated Aβ1–42 mice. In conclusion, our study indicates that curcumin, through targeting PI3K/Akt, regulates GSK3β/Wnt/β-catenin and CREB/BDNF pathways, improving the adult neurogenesis of AD mice.

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Section: The Regulatory Role Of Wnt/β-catenin In Adult Neurogenesismentioning

confidence: 99%

Curcumin Improves Neurogenesis in Alzheimer’s Disease Mice via the Upregulation of Wnt/β-Catenin and BDNF

Lou,

Gong,

Yang

et al. 2024

IJMS

View full text Add to dashboard Cite

show abstract

Structural changes in human brain tissue during prenatal alcoholization at different stages of intrauterine development

Cited by 1 publication

References 19 publications

Curcumin Improves Neurogenesis in Alzheimer’s Disease Mice via the Upregulation of Wnt/β-Catenin and BDNF

Curcumin Improves Neurogenesis in Alzheimer’s Disease Mice via the Upregulation of Wnt/β-Catenin and BDNF

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