Structural Changes in Pseudoexfoliation Syndrome Evaluated with Spectral Domain Optical Coherence Tomography

Eltutar, Kadir; Acar, Fahrettin; Öztürker, Zeynep Kayaarası; Unsal, Erkan; Erkul, Sezin Ozdogan

doi:10.3109/02713683.2015.1039651

Cited by 16 publications

(18 citation statements)

References 32 publications

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“…It is one of the commonest causes of secondary open angle glaucoma and in the Blue Mountains Eye study, patients with PEX in either eye have a two to threefold higher risk of open angle glaucoma 11,12. Although blindness is the most feared outcome, there is growing evidence that even mild visual field loss may have an adverse effect on quality of life.…”

Section: Discussionmentioning

confidence: 99%

“…Most of the work done on measurement of RNFL thickness in PXF syndrome without glaucoma using different OCT machines revealed thinner mean global peripapillary RNFL in eyes with PXF as compared to control group with some variations in quadrantic measurements that may be attributed to variation in age, sample size, ethnicity and type of OCT machine used 2,3,6,12. Ozge et al in their study compared RNFL thickness in eyes with PXF glaucoma, PXF syndrome and healthy controls 15.…”

Section: Discussionmentioning

confidence: 99%

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Comparison of retinal nerve fiber layer thickness in patients having pseudo exfoliation syndrome with healthy adults

Yasmeen

Fatima

Islam³

2016

Pak J Med Sci

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Objective:To compare mean retinal nerve fiber layer (RNFL) thickness in patients having pseudo exfoliation (PXF) with normal age matched controls using spectral domain optical coherence tomography (SD-OCT).Methods:This was a case control study conducted at Armed Forces Institute of Ophthalmology (AFIO) Rawalpindi from 12 June 2013 to 12 January 2014. Seventy eyes (Group A - 35 patients with PXF and Group B - 35 healthy age matched subjects) of more than 40 years of age were included in the study. Intraocular pressure (IOP) was measured with Goldmann applanation tonometer (GAT) and peripapillary RNFL thickness was measured in four quadrants with SD-OCT (Topcon 3D OCT-1000 Mark II) in all subjects. Data was analyzed using the SPSS version 14.Results:Mean age of group A (PXF patients) was 65.63 ± 8.47 years and of group B (Healthy subjects) was 64.31 ± 6.51 years (p = 0.470). Both groups were gender matched with male preponderance (p = 0.673). Mean IOP in each group was 13.80 ± 2.59 mm Hg, and 13.49 ± 2.07 mm Hg respectively (p= 0.578). Mean average peripapillary RNFL thickness was 77.46 ± 12.17 µm in group A and 83.96 ± 10.58 µm in group B. Statistically significant differences were detected between two groups for mean average RNFL thickness (p= 0.020) and mean RNFL thickness in inferior quadrant (p=0.014).Conclusion:PXF patients with normal IOP and visual fields have thin RNFL as compared to healthy age matched controls. Therefore routine assessment and follow up of PXF patients with OCT may help in early diagnosis of PXF glaucoma.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Comparison of retinal nerve fiber layer thickness in patients having pseudo exfoliation syndrome with healthy adults

Yasmeen

Fatima

Islam³

2016

Pak J Med Sci

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“…For the other 3 quadrants, the significance of RNFL thickness reduction varied by OCT type. These variations in measurements may be attributable to the small sample size, different ethnicities and possible systemic diseases of the study participants, and the susceptibility of each quadrant to "thinning" or "cell damage" [7,11,13,33] .…”

Section: Discussionmentioning

confidence: 99%

Retinal Nerve Fiber Layer Thickness Changes in the Pseudoexfoliation Syndrome: A Meta-Analysis of Case-Control Studies

et al. 2017

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Purpose: To evaluate and compare changes in retinal nerve fiber layer (RNFL) thickness in patients with the pseudoexfoliation syndrome (PXS) and healthy controls. Methods: Case-control studies were selected through an electronic search of the Cochrane Controlled Trials Register, PubMed, and Embase. Results were reviewed to ensure that the included studies met prespecified inclusion/exclusion criteria, and the quality of each study was assessed using the Newcastle-Ottawa Scale. All included studies measured average and 4-quadrant (temporal, superior, nasal, and inferior) RNFL thickness using optical coherence tomography (OCT). For the continuous outcomes, we calculated the weighted mean difference (WMD) and 95% confidence intervals (CIs). Results: Eight case-control studies were included in this meta-analysis involving 225 eyes of PXS patients and 208 eyes of healthy controls in total. Statistical analysis revealed that the average RNFL thickness in PXS patients was significantly reduced compared to healthy controls (WMD = −6.91, 95% CI: −9.99 to −3.82, p < 0.0001). Additionally, differences in RNFL thickness in the superior quadrant (WMD = −10.68, 95% CI: −16.40 to −4.95, p = 0.0003), inferior quadrant (WMD = −8.20, 95% CI: −10.85 to −5.55, p < 0.00001), nasal quadrant (WMD = −3.05, 95% CI: −5.21 to −0.90, p = 0.005), and temporal quadrant (WMD = −6.39, 95% CI: −9.98 to −2.80, p = 0.0005) were all significant between the two groups. Conclusions: These results suggest that it is important to evaluate RNFL thickness and the optic nerve head through OCT in patients with PXS in order to determine early glaucomatous damage and start timely intervention prior to visual field loss.

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“…In our study we found that average, superior and nasal RNFL thickness thinner than control group. In that study they reported that the superior and total macular nerve fiber layer thickness, superior total GCC and inner plexiform layer thickness, superior, inner and total GCC thickness were thinner than control subjects [31]. In our study, we just compared mean and minimum GCC thickness and we detected significant difference in these GCC values.…”

Section: Rnfl (µ) Pexsmentioning

confidence: 76%

“…The first study about this subject was that Eltutar et al [31] compared pseudoexfoliation syndrome with control subjects. Macular NFL, ganglion cell layer and inner plexiform layer, total peripapillary nerve fiber layer and ONH parameters were compared.…”

Section: Rnfl (µ) Pexsmentioning

confidence: 99%

Comparison of the ganglion cell complex and retinal nerve fiber layer thickness in pseudoexfoliation syndrome, pseudoexfoliation glaucoma and healthy subjects

Saricaoğlu¹,

Karakurt²,

Hamurcu³

et al. 2017

New Front Ophthalmol

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Purpose: To evaluate the ganglion cell complex (GCC) and retinal nerve fiber layer (RNFL) thickness in the pseudoexfoliation syndrome (PEXS) and pseudoexfoliation glaucoma (PEXG) patients and comparison of the results with the healthy subjects. Methods:In our study, 72 eyes of 45 patients were examined by the Cirrus HD-OCT after pupillary dilation. Nineteen eyes in PEXS (group 1), 23 eyes in PEXG (group 2) and 30 eyes in the control group (group 3) were included. The mean values of GCC, RNFL thickness measurements and quadrant measurement values (superior, inferior, nasal and temporal) were recorded. Results were compared statistically and statistical significance was accepted as p<0.05.Results: Central corneal thickness (CCT) mean values were 566.4 ± 33µ in group 1, 548.1 ± 22.5µ in group 2 and 563.4 ± 27.5µ in group 3. Furthermore, no significant difference was detected in the CCT values (p>0.05). RNFL thickness measurements were 88.1 ± 8.3µ in group 1, 85.6 ± 10.9µ in group 2 and 100.7 ± 11.9µ in group 3. Quadrant measurement values (superior, inferior, nasal and temporal) were respectively 110.2 ± 15.4µ, 112.9 ± 16.4µ, 71.8 ± 10.6µ and 62.9 ± 9.9µ in group 1, 104.4 ± 25.9µ, 113.6 ± 15µ, 65.6 ± 6.2µ, 59.9 ± 9.5µ in group 2 and 122.8 ± 18.1µ, 124.6 ± 29.4µ, 78.9 ± 25.7µ, 68.9 ± 15.4µ in group 3. The significant difference was detected in superior and nasal quadrant values of the RNFL thickness between the groups (p<0.05), no significant differences in the inferior and temporal quadrant values (p>0.05). PEX groups (group 1 and group 2) compared with the control group, the significant difference was detected in the mean and minimum GCC values (p<0.05). Conclusions:The evaluation of the GCC and RNFL thickness measurements in the PEXS and PEXG patients can give valuable information to the clinician. Moreover, they can help to detect the transition from PEXS to PEXG.

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Structural Changes in Pseudoexfoliation Syndrome Evaluated with Spectral Domain Optical Coherence Tomography

Abstract: In PEX syndrome, similar decreases of the GCC and NFL occurred, and a high correlation existed between the two. Therefore, GCC can potentially be used to detect the early stages of PEX glaucoma.

Cited by 16 publications

References 32 publications

Comparison of retinal nerve fiber layer thickness in patients having pseudo exfoliation syndrome with healthy adults

Comparison of retinal nerve fiber layer thickness in patients having pseudo exfoliation syndrome with healthy adults

Retinal Nerve Fiber Layer Thickness Changes in the Pseudoexfoliation Syndrome: A Meta-Analysis of Case-Control Studies

Comparison of the ganglion cell complex and retinal nerve fiber layer thickness in pseudoexfoliation syndrome, pseudoexfoliation glaucoma and healthy subjects

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