Structural changes in the oviductal wall during passage of unfertilized cumulus‐Oocyte complexes in mice

Sato, Eimei; Ando, Naoki; Takahashi, Yūji; Miyamoto, Hajime; Toyoda, Yutaka

doi:10.1002/ar.1092410207

Cited by 6 publications

(4 citation statements)

References 22 publications

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“…In animals with a long luteal phase, movement of cilia is considered to be useful for transfer of the gametes from the ovary to the uterus [10,24]. In the mouse, however, relaxation of the muscle coat surrounding the oviductal epithelium was reported to aid in this transportation [25]. We observed that ciliated cells were dominant in diestrus and proestrus.…”

Section: Discussionmentioning

confidence: 83%

Alterations in Cell Proliferation and Morphology of Ampullar Epithelium of the Mouse Oviduct during the Estrous Cycle.

Morita

Miyamoto

Sugimoto

et al. 1997

Journal of Reproduction and Development

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Abstract. We examined cell proliferation and morphological changes in the ampullar epithelium of mouse oviducts. Oviducts were labeled in vivo by administration of 5-bromo-2'-deoxyuridine (BrdU) on each day of the estrous cycle. The frequency of the ampullar S-phase epithelial cells labeled with BrdU changed according to the estrous cycle, with the highest proportion at proestrus. The morphology of the ampullar epithelia also changed during the estrous cycle. In estrus and metestrus, most of the ampullar epithelial cells were comprised of non-ciliated secretory cells. In diestrus and proestrus, however, the ciliated cells were dominant among the ampullar epithelial cells. Electron microscopic observations indicated that the ampullar non-ciliated secretory cells in metestrus had numerous secretory granules, and fusion of these granules with the plasma membrane, i.e. exocytosis, was evident. The present results indicate that cell proliferation and morphology of ampullar epithelia of mouse oviducts vary according to phase of the estrous cycle.

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Section: Discussionmentioning

confidence: 83%

Alterations in Cell Proliferation and Morphology of Ampullar Epithelium of the Mouse Oviduct during the Estrous Cycle.

Morita

Miyamoto

Sugimoto

et al. 1997

Journal of Reproduction and Development

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“…This phenomenon, known as “cumulus expansion”, facilitates the detachment of the COC from the follicular wall, the extrusion of the COC during ovulation, 49 ) and its capture by the oviductal fimbria; 50 ) promotes the acrosomal reaction in spermatozoa; 51 ) and transports the ovulated COC in the oviduct. 52 ) Furthermore, we have clarified that granulosa cells express an inhibitor of the induction of meiotic resumption and that cumulus expansion interferes with this inhibitor to induce the resumption of meiosis in oocytes in mammals. 53 – 56 )…”

Section: The Intraovarian Mechanism Controlling the Induction Of Oocymentioning

confidence: 97%

Intraovarian control of selective follicular growth and induction of oocyte maturation in mammals

Sato

2015

Proceedings of the Japan Academy. Ser. B: Physical and Biologic

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In newborn mammals, most of the germ cell population rests in a pool of quiescent small follicles in the ovaries. Regularly throughout adulthood, a small percentage of these oocytes and follicles grows to a certain stage of development and then either degenerates or matures and ovulates. This entire process is under both exogenous and endogenous control. Recent work, including my laboratory’s, has clarified that cytokines and glycosaminoglycans are involved as exogenous and endogenous factors in ovarian follicular development, atresia, and maturation in mammals. The present article describes our contribution regarding the cytokines and ovarian glycosaminoglycans that act as intraovarian regulators of follicular development and oogenesis, including oocyte maturation, in mammals.

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“…Our approach will certainly facilitate the elucidation of gene expression profiles during the series of morphophysiological events that characterize the Mu¨llerian duct-derived organs during the estrous cycle. [38][39][40] In addition, our study indicates that the upper vagina of the laboratory mouse is a convenient model organ for addressing basic and applied questions concerning the process of cornification in a developing stratified squamous epithelium.…”

Section: Discussionmentioning

confidence: 80%

A simple method for inducing estrous cycle stage-specific morphological changes in the vaginal epithelium of immature female mice

et al. 2016

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The vaginal epithelium of the adult female laboratory rodent changes from mucous secretion to cornification over the course of the estrous cycle. The morphophysiological changes occur with such regularity, accuracy and precision that the specific stage of the estrous cycle in the rat can be determined by inspection of the vaginal opening and/or exfoliative vaginal cytology. However, in the mouse, post-mortem vaginal histology is often required to determine the estrous cycle stage for ensuring the required level of reliability. Consequently, an excess number of female adult mice are needed to allow for the delivery of sufficient numbers of mice in a desired estrous cycle stage. In this study, we demonstrate that the standard procedure for oocyte superovulation and collection in the laboratory mouse (e.g. injection of equine chorionic gonadotropin followed 48 h later by human chorionic gonadotropin) can also be reliably used to induce changes in the epithelium of 3.5-week-old mouse vaginas in an estrous cycle stage-specific manner (e.g. establishment and replacement of a mucous secreting epithelium with a cornified epithelium; induction of cornification-associated loricrin expression). The superovulation protocol thus allows for the efficient and economic induction of estrous cycle stage-specific characteristics in the Müllerian duct-derived vagina thereby avoiding the necessity of post-mortem identification of the estrous cycle stage. In addition, our study indicates that the laboratory mouse vagina is an excellent organ for studying the sequence of events leading to cornification.

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Structural changes in the oviductal wall during passage of unfertilized cumulus‐Oocyte complexes in mice

Abstract: These results indicate that oocyte-cumulus cell complexes influence the structure of the oviductal wall during the passage in the oviduct.

Cited by 6 publications

References 22 publications

Alterations in Cell Proliferation and Morphology of Ampullar Epithelium of the Mouse Oviduct during the Estrous Cycle.

Alterations in Cell Proliferation and Morphology of Ampullar Epithelium of the Mouse Oviduct during the Estrous Cycle.

Intraovarian control of selective follicular growth and induction of oocyte maturation in mammals

A simple method for inducing estrous cycle stage-specific morphological changes in the vaginal epithelium of immature female mice

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