Structural Changes Induced By Gibberellic Acid in the Renal Cortex of Adult Male Albino Rats

Sabry, Marwa

doi:10.15406/mojap.2017.03.00080

Cited by 6 publications

(2 citation statements)

References 31 publications

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“…However, they pointed out that fibroblasts may be transformed from the flattened cells, with their flattened nuclei, lining some tubules. The lesion that occurred in the renal corpuscles in the treated group could be attributed to peritubular fibrosis and it was in agreement with that seen by Abdel-Rahman et al, (2017) [41] .…”

Section: Discussionsupporting

confidence: 91%

Effect of Perfluorooctane Sulfonate on the Renal Cortex of Adult Male Albino Rats and the Possible Ameliorating Role of Quercetin

Amin,

Agaga

2022

Journal of Medical Histology

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Introduction: Perfluorinated chemicals (PFCs) are materials that have many important industrial applications. Quercetin is a unique bioflavonoid that known with its antioxidant activity. Aim: To evaluate the histopathological effect of (PFOS) on rat renal cortex and the possible protective role of Quercetin. Materials and Methods: 45 adult male albino rats were divided into three groups, each contained 15 rats. The first group was the control group (I), which was splitted into three equal subgroups. The second group was (PFOS) receiving group (II) at a dose of 20mg /kg/day by gavage for 28 days. The third group was the protective group (III) which received the same dose of (PFOS) as group (II) in combination with Quercetin at a dose of 50 mg/kg b.w orally for 28 days. At the end of the study, the kidneys were dissected out and prepared for light microscopic examination. Results:The kidney sections of (PFOS) receiving group showed distortion of normal histology in the form of variations in the size and shape of renal glomeruli, peri glomerular inflammatory cell infiltrations, Disorganized renal tubules with dark stained (pyknotic) nuclei, cystic luminal dilatation and cytoplasmic vacuolations. In addition, some cortical convoluted tubules showed areas of interstitial hemorrhage, necrosis and exfoliation of tubular epithelial cells. Increased collagen fibers deposition and immune expression of PCNA and INOS stained sections. All these findings were improved by co-administration of Quercetin. Conclusion: Quercetin played an important role in improving the toxic effects of (PFOS) on kidney tissue of adult male rats.

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Section: Discussionsupporting

confidence: 91%

Effect of Perfluorooctane Sulfonate on the Renal Cortex of Adult Male Albino Rats and the Possible Ameliorating Role of Quercetin

Amin,

Agaga

2022

Journal of Medical Histology

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“…This is considered an adaptive physiological response attempting to limit cell damage by toxic materials or their metabolites. This inflammatory reaction observed in both treated groups in this study is considered a defensive response of tissues either to oxidative stress-induced injury caused by dimethoate and methomyl or the bacterial isolate [67,68].…”

Section: Discussionmentioning

confidence: 83%

Microbial Detoxification of Dimethoate and Methomyl Residues in Aqueous Media

Derbalah

Massoud

El‐Mehasseb

et al. 2021

Water

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The extensive and random application of major organic pollutants, mainly pesticides, threatens ecosystems and human health. The present study was conducted to isolate and identify microorganisms from some water resources contaminated with pesticides. We investigated the ability of the identified microbes to grow in water spiked with dimethoate and methomyl. We also evaluated the potential effect of the identified microbial isolates on dimethoate and methomyl biodegradation in water. In addition, the total detoxification of dimethoate and methomyl residues in water after treatment with the most effective microbial isolates was confirmed using toxicity tests and analyzing biochemical parameters and histopathological changes in the kidney and liver of treated rats. The microbial isolates were identified as Xanthomonas campestris pv. Translucens and Aspergillus fumigates. Results showed that X. campestris pv. Translucens and A. fumigatus grow in media supplemented with dimethoate and methomyl faster than in other media without both pesticides. About 97.8% and 91.2% of dimethoate and 95% and 87.8% of methomyl (initial concentration of both 5 mg L−1) were biodegraded within 32 days of incubation with X. campestris pv. Translucens and A. fumigatus, respectively. There was no remaining toxicity in rats treated with dimethoate- and methomyl-contaminated water with respect to biochemical parameters and histopathological changes. Collectively, the identified bacterial isolate showed high potential for the complete degradation of dimethoate and methomyl residues in water.

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Beneficial effects of folic acid on the kidneys and testes of adult albino rats after exposure to methomyl

et al. 2018

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The aim of this study was to evaluate the protective effect of folate against methomyl-induced toxicity on the kidneys and testes of male rats. Adult male albino rats were divided into four groups; Group I served as the control (vehicle), Group II received folic acid (1.1 mg per kg b.wt.), Group III methomyl (1 mg per kg b.wt.) and Group IV folic acid and methomyl. Treatments were administered oral gavage on a daily basis for 14 weeks. Thereafter blood samples were collected and serum creatinine, testosterone and total antioxidant capacity (TAC) were determined. Animals were sacrificed and semen analysis was conducted. The kidneys and testes were excised and malondialdehyde (MDA) levels were determined. Histopathological and immunohistochemical analyses for caspase-3 were also undertaken. Methomyl treatment resulted in a significant ( < 0.001) elevation of creatinine and MDA levels and significant ( < 0.001) reduction in testosterone and TAC levels. Furthermore, methomyl caused a significant ( < 0.001) reduction in sperm quality. Histopathological examination indicated testicular and renal damage with strong immunoreactivity for caspase-3. Functional and tissue damage was prevented in rats treated with a combination of methomyl and folic acid. This is ascribed to the ability of folate to directly scavenge reactive oxygen species and indirectly enhance cellular redox homeostasis. This study identified that folic acid supplementation may have a beneficial effect in preventing or reducing the deleterious effects of methomyl exposure on kidney as well as testis structure and function. Future studies should focus on the fertility outcome/pregnancy index in rats.

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Structural Changes Induced By Gibberellic Acid in the Renal Cortex of Adult Male Albino Rats

Cited by 6 publications

References 31 publications

Effect of Perfluorooctane Sulfonate on the Renal Cortex of Adult Male Albino Rats and the Possible Ameliorating Role of Quercetin

Effect of Perfluorooctane Sulfonate on the Renal Cortex of Adult Male Albino Rats and the Possible Ameliorating Role of Quercetin

Microbial Detoxification of Dimethoate and Methomyl Residues in Aqueous Media

Beneficial effects of folic acid on the kidneys and testes of adult albino rats after exposure to methomyl

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