Structural changes of a sodium dodecyl sulfate (SDS) micelle induced by alcohol molecules

Méndez-Bermúdez, José Guillermo; Domínguez, Héctor

doi:10.1007/s00894-015-2904-x

Cited by 17 publications

(13 citation statements)

References 32 publications

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“…The SANS data for the d 25 -SDS system is modelled instead to show the presence of corpuscular/oblate ellipsoidal aggregates which we take to be mixed SDS/co-surfactant bicelles, with around 30% SDS and 70% cetyl/stearyl alcohol. There have been no other reports of aggregates of this type being seen in aqueous creams but it is pertinent here to note that Zarbahksh et al have repeatedly observed surfactant-rich layers which they speculate to contain surfactant micelles in the aqueous phase close to the surfactant monolayers formed at the decane-and hexadecane-water interfaces 22,39,40 , and Méndez-Bermúdez and Dominguez have shown through coarse grain molecular dynamics simulations that bilayer aggregates of this type are formed in aqueous dispersions of SDS and hexadecanol when the proportion of hexadecanol is high 41 . Experimentally, when the component oil and aqueous phases are mixed in the preparation of a cream, such aggregates would likely serve as intermediaries in the transfer of amphiphiles between the lamellae and the surfaces of the oil droplets.…”

Section: Discussionmentioning

confidence: 84%

Revealing the Hidden Details of Nanostructure in a Pharmaceutical Cream

Ahmadi

Mahmoudi

et al. 2020

Sci Rep

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Creams are multi-component semi-solid emulsions that find widespread utility across a wide range of pharmaceutical, cosmetic, and personal care products, and they also feature prominently in veterinary preparations and processed foodstuffs. The internal architectures of these systems, however, have to date been inferred largely through macroscopic and/or indirect experimental observations and so they are not well-characterized at the molecular level. Moreover, while their long-term stability and shelflife, and their aesthetics and functional utility are critically dependent upon their molecular structure, there is no real understanding yet of the structural mechanisms that underlie the potential destabilizing effects of additives like drugs, anti-oxidants or preservatives, and no structure-based rationale to guide product formulation. In the research reported here we sought to address these deficiencies, making particular use of small-angle neutron scattering and exploiting the device of H/D contrast variation, with complementary studies also performed using bright-field and polarised light microscopy, smallangle and wide-angle X-ray scattering, and steady-state shear rheology measurements. through the convolved findings from these studies we have secured a finely detailed picture of the molecular structure of creams based on Aqueous Cream BP, and our findings reveal that the structure is quite different from the generic picture of cream structure that is widely accepted and reproduced in textbooks. Oil-in-water creams are widely used in pharmaceutical products formulated to treat conditions like atopic dermatitis, rosacea and psoriasis 1. They also form the basis of veterinary medications used to assist wound-healing and treat skin infections 2 , and they are the basis too of a great many personal care products, spanning make-up foundations, anti-perspirants, sun lotions and deodorants 3. All such products are complex, multi-component colloids in which the constituent oil and water phases are stabilised through the addition of one or more ionic, non-ionic or zwitterionic surfactants, in combination with one or more co-surfactants (sometimes referred to as consistency enhancers) which might be long chain fatty acids, fatty alcohols or monoglycerides 4,5. Other components which might be added include humectants such as propylene glycol, anti-oxidants like α-tocopherol acetate, and preservatives like phenoxyethanol 6. The molecular architecture of any given cream formulation will clearly vary according to its chemical composition, and this in turn will determine its chemical and physical stability, and also impact the cream's sensory aesthetics and efficacy as a cosmetic, pharmaceutical, or veterinary product. Despite much research into the properties of creams and their many years of use, however, our understanding of their internal molecular structure is still far from complete, with the unavoidable consequence, therefore, that they are still formulated only in a semi-empirical manner. Junginger and co-workers 7 ...

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Section: Discussionmentioning

confidence: 84%

Revealing the Hidden Details of Nanostructure in a Pharmaceutical Cream

Ahmadi

Mahmoudi

et al. 2020

Sci Rep

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“…As an important component in chemical flooding, understanding the roles of cosurfactants is of great significance. Many studies have been carried out to clarify their roles at water–air or water–oil interfaces, such as theories, experiments, − and simulations ,, (Table ). The most commonly used cosurfactants in chemical flooding are medium-chain alcohols, including propyl, butyl, and pentyl alcohols.…”

Section: Introductionmentioning

confidence: 99%

Role of Alcohol as a Cosurfactant at the Brine–Oil Interface under a Typical Reservoir Condition

Nan

Jin

2020

Langmuir

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A cosurfactant is a chemical used in combination with a surfactant to enrich the properties of the primary surfactant formulation. Understanding the roles of a cosurfactant is of great importance in designing a chemical solution with desired features. Herein, we report a molecular dynamics simulation study to explore the roles of alcohol (propanol) as a cosurfactant at a brine−oil interface in chemical flooding under a typical reservoir condition (353 K and 200 bar). We demonstrate that propanol, as a cosurfactant, can be transported through oil and brine phases; such a dislocation of propanol in the system is a dynamic process. The interfacial tension between brine and oil decreases as propanol concentration in the system increases. This is because propanol can form hydrogen bonds with water molecules while it decreases the density of hydrogen bonds formed between the surfactant and water. The introduction of propanol does not always increase the local fluidity of surfactants at the interfaces. A local maximum fluidity was observed when the surfactants are more perpendicular to the interfaces. Our work should provide important insights into the design of the surfactant formulas for chemical flooding during enhanced oil recovery.

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“…to determine the effect of methanol, ethanol, n-propanol and iso-propanol on SDS/water systems [18][19][20] . Research on other SDS/alcohol/water systems has been reported by several authors [21][22][23][24][25][26][27][28][29][30][31][32][33][34][35] .…”

Section: Volumetric Measurements Have Been Madementioning

confidence: 99%

“…Among many the structure of SDS micelles in water has been characterized by various methods, e.g. have been chosen for this study 18 .…”

Section: Introductionmentioning

confidence: 99%

The Solvent Influence on Thymidine-SDS-Alcohol Micelle System: Studies With UV-Vis Technique

Bhattarai¹,

Hw²,

Grzegorek³

2018

Am J Pharmacol Pharmacother

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Vis technique are reported. The solvents selected were the following aliphatic alcohols: ethanol, n-butanol, n-heptanol and n-decanol. In this paper first time are presented data for SDS micelles in alcohols with some addition of water. In all studied systems concentrations of SDS (sodium dodecyl sulphate) were above CMC. Water concentration in the studied systems was defined by R parameter according to relation: R=[H 2 O]/[AOT] and was between 0 to 50 depending on the system. In the present work SDS micelles mimicked in a very simple way the structural aspects of some domain in bio membranes. The distribution of thymidine, which is one of the pyrimidine bases of living matter (is found in the nucleic acid DNA) between organic and micellar phase was the object of our study. Using UV-Vis technique the investigation of thymidine/alcohol/SDS/water system at 25°C were done, and next the results were discussed in the context of influence an aliphatic alcohol on thymidine interaction with SDS micelles. Moreover, obtained results involve us to predict the privilege location of thymidine molecules in SDS micelles. The experimental values of thymidine absorbance as a function of surfactant Wachnik et al.

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Structural changes of a sodium dodecyl sulfate (SDS) micelle induced by alcohol molecules

Cited by 17 publications

References 32 publications

Revealing the Hidden Details of Nanostructure in a Pharmaceutical Cream

Revealing the Hidden Details of Nanostructure in a Pharmaceutical Cream

Role of Alcohol as a Cosurfactant at the Brine–Oil Interface under a Typical Reservoir Condition

The Solvent Influence on Thymidine-SDS-Alcohol Micelle System: Studies With UV-Vis Technique

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