Structural changes of polymer-coated microgranules and excipients on tableting investigated by microtomography using synchrotron X-ray radiation

Kajihara, Ryusuke; Noguchi, Shuji; Iwao, Yasunori; Suzuki, Yoshio; Terada, Yasuko; Uesugi, Kentaro; Itai, Shigeru

doi:10.1016/j.ijpharm.2015.02.007

Cited by 9 publications

(4 citation statements)

References 24 publications

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“…In this method, high purity silicone detection is used to take the XRF emitted from the matter (specimen). 10,11) A schematic of the particle coating process is shown in Fig. 2.…”

Section: Methodsmentioning

confidence: 99%

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An Application of X-Ray Fluorescence as Process Analytical Technology (PAT) to Monitor Particle Coating Processes

Nakano¹,

Katakuse

Azechi

2018

CHEMICAL & PHARMACEUTICAL BULLETIN

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An attempt to apply X-Ray Fluorescence (XRF) analysis to evaluate small particle coating process as a Process Analytical Technologies (PAT) was made. The XRF analysis was used to monitor coating level in small particle coating process with at-line manner. The small particle coating process usually consists of multiple coating processes. This study was conducted by a simple coating particles prepared by first coating of a model compound (DL-methionine) and second coating by talc on spherical microcrystalline cellulose cores. The particles with two layered coating are enough to demonstrate the small particle coating process. From the result by the small particle coating process, it was found that the XRF signal played different roles, resulting that XRF signals by first coating (layering) and second coating (mask coating) could demonstrate the extent with different mechanisms for the coating process. Furthermore, the particle coating of the different particle size has also been investigated to evaluate size effect of these coating processes. From these results, it was concluded that the XRF could be used as a PAT in monitoring particle coating processes and become powerful tool in pharmaceutical manufacturing.

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“…In this method, high purity silicone detection is used to take the XRF emitted from the matter (specimen). 10,11) A schematic of the particle coating process is shown in Fig. 2.…”

Section: Methodsmentioning

confidence: 99%

“…9) An X-ray fluorescence (XRF) has been used as an in-process control for estimating the thickness of laminating and coating in electronics fields for long time. 10,11) The XRF enables simple and effective measurement with non-destructive manner. Although the XRF is widely used for other fields such as material science, painting etc.…”

mentioning

confidence: 99%

An Application of X-Ray Fluorescence as Process Analytical Technology (PAT) to Monitor Particle Coating Processes

Nakano¹,

Katakuse

Azechi

2018

CHEMICAL & PHARMACEUTICAL BULLETIN

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“…Critical parameter of the coating layer is the coating thickness uniformity and their distribution. The thickness of the coating layer can typically vary from 5 to 100

m [ 198 ], and the uniformity of the coating layer is affected during the coating process [ 199 , 320 , 321 ]. The performance and the quality of the coating layer can also be determined by simulation and modelling tools such as discrete element method, and can be used to optimize the coating process [ 322 ].…”

Section: Tablet Characterizationmentioning

confidence: 99%

Characterization of Pharmaceutical Tablets by X-ray Tomography

et al. 2023

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Solid dosage forms such as tablets are extensively used in drug administration for their simplicity and large-scale manufacturing capabilities. High-resolution X-ray tomography is one of the most valuable non-destructive techniques to investigate the internal structure of the tablets for drug product development as well as for a cost effective production process. In this work, we review the recent developments in high-resolution X-ray microtomography and its application towards different tablet characterizations. The increased availability of powerful laboratory instrumentation, as well as the advent of high brilliance and coherent 3rd generation synchrotron light sources, combined with advanced data processing techniques, are driving the application of X-ray microtomography forward as an indispensable tool in the pharmaceutical industry.

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“…Prior to this the method was used to take a look inside blended materials like e.g. fibre reinforced polymers or other materials with rapid density gradients like foamed elastomers, fatigue damaged polymer composites or polymer coated materials . X‐Ray tomography is predicated on the transmission of the X‐ray beam, which is reduced in intensity depending on the density of the material irradiated.…”

Section: Experimental Investigationsmentioning

confidence: 99%

Consumption and diffusion of oxygen during the thermoxidative ageing process of elastomers

Herzig

Johlitz

Lion

2016

Materialwissenschaft Werkst

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Thermoxidative ageing of elastomers is investigated by having a closer look on the consumption and diffusion of oxygen during the exposure to elevated temperatures. After the introduction of some basic theory an experimental set‐up is described, which enables the measurement of the oxygen amount being absorbed during weathering. Hence the oxygen consumption of natural rubber was detected at elevated temperatures and for varying exposure times. The correlation of changes in the mechanical properties and the oxygen consumption is analysed in order to get new awareness of oxidation affecting the mechanical behaviour. Influences of diffusion effects on the degradation are investigated by the use of micro X‐ray tomography, which detects minor changes in density generated by oxidation. Density profiles over the cross‐section of the samples are created, which illustrate the appearance of diffusion‐limiting oxidation. The results offer a closer look at the thermoxidative ageing of natural rubber and should help to get a better understanding of the degradation during ageing. Finally the findings may improve the life‐time prediction of elastomeric components by providing the basis for the development of advanced material models.

show abstract

Structural changes of polymer-coated microgranules and excipients on tableting investigated by microtomography using synchrotron X-ray radiation

Cited by 9 publications

References 24 publications

An Application of X-Ray Fluorescence as Process Analytical Technology (PAT) to Monitor Particle Coating Processes

An Application of X-Ray Fluorescence as Process Analytical Technology (PAT) to Monitor Particle Coating Processes

Characterization of Pharmaceutical Tablets by X-ray Tomography

Consumption and diffusion of oxygen during the thermoxidative ageing process of elastomers

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