Structural characterisation and immunomodulatory activity of a polysaccharide isolated from lotus (Nelumbo nucifera Gaertn.) root residues

Hu, Weicheng; Jiang, Yunyao; Xue, Qi; Sun, Fengting; Zhang, Jianmei; Zhou, Jing; Niu, Zhiqiang; Li, Qiuting; Li, Fu; Shen, Ting

doi:10.1016/j.jff.2019.103457

Cited by 37 publications

(28 citation statements)

References 50 publications

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“…Macrophage production was mediated by signaling receptors such as toll-like 4 (TLR4), type A hijacker (RAS) and glucan (GR). Finally, Hu et al (2019) isolated and purified a homogeneous polysaccharide, with bioactive properties of the lotus root. It has been shown that the polysaccharide induces macrophage activation through the PI3K/Akt and MAPKs signal pathways, which had not yet been reported.…”

Section: Polysaccharides With Properties To Modulate the Immunementioning

confidence: 99%

Polysaccharides obtained from natural edible sources and their role in modulating the immune system: Biologically active potential that can be exploited against COVID-19

Barbosa

Carvalho

2021

Trends in Food Science & Technology

124

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Section: Polysaccharides With Properties To Modulate the Immunementioning

confidence: 99%

Polysaccharides obtained from natural edible sources and their role in modulating the immune system: Biologically active potential that can be exploited against COVID-19

Barbosa

Carvalho

2021

Trends in Food Science & Technology

124

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“…This study comprises three treatment groups, (1) AA-treated groups (50, 6.25, and 0.78 µg/ml), (2) MA-treated groups (50, 6.25, and 0.78 µg/ ml), and (3) a combination of AA-and MA-treated groups (AA + MA: 25 + 25, 3.13 + 3.13, and 0.39 + 0.39 µg/ml), as well as two control groups, (1) positive control [lipopolysaccharides (LPS) 100 ng/ml] and (2) untreated control (0.05% DMSO). Each sample collection and bioassay was conducted after a 24-hour incubation phase to assess immunomodulatory enhancing properties based on the measured parameters Hu et al, 2019).…”

Section: Cell Culture Maintenance and Treatmentmentioning

confidence: 99%

Immunostimulatory effects of asiatic acid and madecassoside on the phagocytosis activities of macrophages cell line (J774A.1)

Harun¹,

Ahmad²,

Suppian³

2021

J Appl Pharm Sci

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“…Antioxidant Antidiarrheal effect (Wang, Zhao, et al, 2015) Nelumbo nucifera Gaertn. Folium Nelumbinis Polysaccharides Immunomodulatory activity (Hu et al, 2019) Raphanus sativus L. Semen Raphani Isothiocyanates Anticancer (Pocasap, Weerapreeyakul, Tanthanuch, & Thumanu, 2017) (Continues) Antimicrobial Anticancer (Zhou et al, 2019) Piper longum L. Fructus Piperis Longi Piperine Neuroprotective effects (Peng et al, 2019) Anti-inflammatory activity (Wang et al, 2017) Codonopsis pilosula (Franch.) Nannf.…”

Section: Platycodon Grandiflorummentioning

confidence: 99%

Advances in understanding of health‐promoting benefits of medicine and food homology using analysis of gut microbiota and metabolomics

et al. 2020

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The health-promoting benefits of medicine and food homology (MFH) are known for thousands of years in China. However, active compounds and biological mechanisms are unclear, greatly limiting clinical practice of MFH. The advent of gut microbiota analysis and metabolomics emerge as key tools to discover functional compounds, therapeutic targets, and mechanisms of benefits of MFH. Such studies hold great promise to promote and optimize functional efficacy and development of MFH-based products, for example, foods for daily dietary supplements or for special medical purposes. In this review, we summarized pharmacological effects of 109 species of MFH approved by the Health and Fitness Commission in 2015. Recent studies applying genome sequencing of gut microbiota and metabolomics to explain the activity of MFH in prevention and management of health consequences were extensively reviewed. We discussed the potentiality in future to decipher functional activities of MFH by applying metabolomics-based polypharmacokinetic strategy and multiomics technologies. The needs for personalized MFH recommendations and comprehensive databases have also been highlighted. This review emphasizes current achievements and challenges of the analysis of gut microbiota and metabolomics as a new avenue to understand MFH. K E Y W O R D S gut microbiota, medicine and food homology, metabolomics, multiomics technology Abbreviations: IBD, inflammatory bowel disease; LPS, lipopolysaccharide; MFH, medicine and food homology; SCFA, short-chain fatty acid; TCMIO, a comprehensive database of traditional Chinese medicine on immuno-oncology; WEGL, water extract of Ganoderma lucidum mycelium This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

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Structural characterisation and immunomodulatory activity of a polysaccharide isolated from lotus (Nelumbo nucifera Gaertn.) root residues

Cited by 37 publications

References 50 publications

Polysaccharides obtained from natural edible sources and their role in modulating the immune system: Biologically active potential that can be exploited against COVID-19

Polysaccharides obtained from natural edible sources and their role in modulating the immune system: Biologically active potential that can be exploited against COVID-19

Immunostimulatory effects of asiatic acid and madecassoside on the phagocytosis activities of macrophages cell line (J774A.1)

Advances in understanding of health‐promoting benefits of medicine and food homology using analysis of gut microbiota and metabolomics

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