Structural Characteristic of the Arcuate Fasciculus in Patients with Fluent Aphasia Following Intracranial Hemorrhage: A Diffusion Tensor Tractography Study

Ryu, Hyeong; Park, Chan-Hyuk

doi:10.3390/brainsci10050280

Cited by 10 publications

(13 citation statements)

References 38 publications

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“…Fluent aphasia usually involves the Wernicke range of the hinder superior temporal lobe, which manifests as language. The output is relatively smooth, but there is liable understanding injury [ 3 ]. Arcuate fasciculus (AF) is a language pluck footpath that connects Broca's conversation region and Wernicke's understanding range.…”

Section: Related Workmentioning

confidence: 99%

“…Arcuate fasciculus (AF) is a language pluck footpath that connects Broca's conversation region and Wernicke's understanding range. It plays a considerable role in diction function [ 3 ]. The gradation of AF ill is different, which entice to different strictness of aphasia [ 4 ].…”

Section: Related Workmentioning

confidence: 99%

“…Cerebral infarct is the most threadbare example of stroke, accounting for 69.6% to 70.8% of strokes in my country [ 1 , 2 ]. Aphasia is a common prognostic of cerebral infarct, representing 21% to 38% of patients with acute cerebral infarct [ 3 , 4 ]. Language barriers seriously jeopardize the purgative and immaterial soundness of patients, bring intellective and economic crushing to patients and their families, and increase social encumbrance.…”

Section: Introductionmentioning

confidence: 99%

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The Recovery Mechanism of Standardized Aphasia in Intelligent Medical Treatment

Rong

Liu²,

2022

Contrast Media & Molecular Imaging

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A total of 35 patients with aphasia after cerebral infarct were included. Among them, 15 conjunctures were sensory (Wernicke’s) aphasia and 20 cases were motor (Broca) aphasia. Perfusion Weighted Imaging (PWI) and Magnetic Resonance Spectroscopy (MRS) were performed on the attached hard area to measure the local cerebral blood flow (rCBF) and sectional cerebral blood compass (rCBV), mean conveyance tense (MTT), point delay (TTP), and N-acetylaspartate (NAA), choline (Cho), creatine (Cr)), and lactic acidic (lactate, Lac) and generally a relative analysis. Results. Among the patients with contaminative aphasia, rCBF was way diminished in the contralateral mirror extent. MTT and TTP were significantly longer than the contralateral mirror range, NAA and Cho were sullenness than the contralateral side, and the Lac peak appeared. The distinction was statistically taken (P < 0.05). Compared with the contralateral mirror circumference, motor aphasia was significantly reduced in rCBF and rCBV, and MTT and TTP were way prolonged. NAA and Cho were reduced compared with the contralateral side, and the Lac peak appeared. The dispute was statistically momentous (P < 0.05). Conclusion. After cerebral infarction, the language cosine extent of patients with aphasia bestows a rank of hypoperfusion and light metabolism, suggesting that it may be the pathogeny of aphasia.

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Section: Related Workmentioning

confidence: 99%

Section: Related Workmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The Recovery Mechanism of Standardized Aphasia in Intelligent Medical Treatment

Rong

Liu²,

2022

Contrast Media & Molecular Imaging

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“…Conservative treatment is considered when a hematoma is smaller than 10 cm 3 , whereas surgery such as craniotomy and ventriculoperitoneal shunt is considered with moderate neurologic deficits or a hematoma larger than 30 cm 3 [14]. Putaminal hemorrhage with large lesion volume (LV) in the dominant hemisphere may cause both language deficits including conduction aphasia and effect change in the microstructure of the AF [15,16]. However, precise estimation of the AF affected by the LV of putaminal hemorrhage had been limited because conventional brain imaging techniques, such as computed tomography or magnetic resonance imaging, do not clearly discriminate the AF from adjacent white matter [1,17].…”

Section: Introductionmentioning

confidence: 99%

Relationships among language ability, the arcuate fasciculus and lesion volume in patients with putaminal hemorrhage: a diffusion tensor imaging study

Cho

Jang

2021

J. Integr. Neurosci.

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Relationships among language ability, arcuate fasciculus and lesion volume were investigated by use of diffusion tensor tractography in patients with putaminal hemorrhage. Thirty-three right-handed patients within six weeks of hemorrhage onset were recruited. Correlation of the aphasia quotient with subset (fluency, comprehension, repetition, naming) scores, diffusion tensor tractography parameters and lesion volume of patients, aphasia quotient (r = 0.446) with subset (naming: r = 0.489) score had moderate positive correlations with fractional anisotropy of the left arcuate fasciculus. The aphasia quotient subset (repetition) score had a strong positive correlation with fractional anisotropy of the left arcuate fasciculus (r = 0.520), whereas, aphasia quotient subset (fluency and comprehension) scores had no significant correlations with fractional anisotropy of the left arcuate fasciculus after Benjamini–Hochberg correction. Aphasia quotient (r = 0.668) with subset (fluency: r = 0.736, comprehension: r = 0.739, repetition: r = 0.649, naming: r = 0.766) scores had strong positive correlations with the tract volume of the left arcuate fasciculus and strong negative correlations with lesion volume (r = –0.521, fluency: r = –0.520, comprehension: r = –0.513, repetition: r = –0.518, naming: r = –0.562). Fractional anisotropy of the left arcuate fasciculus had a moderate negative correlation with lesion volume (r = –0.462), whereas the tract volume of the left arcuate fasciculus had a strong negative correlation with lesion volume (r = –0.700). According to the result of mediation analysis, tract volume of the left arcuate fasciculus fully mediated the effect of lesion volume on the aphasia quotient. Regarding the receiver operating characteristic curve, the lesion volume cut-off value was 29.17 cm3 and the area under the curve (0.74), sensitivity (0.77) and specificity (0.80) were higher than those of fractional anisotropy, tract volume and aphasia quotient cut-off values. It was found that level of language disability was related to lesion volume as well as to injury severity of arcuate fasciculus in the dominant hemisphere of patients with putaminal hemorrhage. In particular, the tract volume of the arcuate fasciculus in the dominant hemisphere fully mediated the effect of lesion volume on language ability. Additionally, a lesion volume of approximately 30 cm3 was helpful in discriminating arcuate fasciculus discontinuation in the dominant hemisphere.

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“…Another study by Ryu and Park [ 12 ] investigated the relationship between the structural characteristics of the left arcuate fasciculus (AF) reconstructed using diffusion tensor images (DTI) to the type of fluent aphasia according to hemorrhage lesions in patients with fluent aphasia following intracranial hemorrhage (ICH). They analyzed the dataset of five subjects with fluent aphasia following ICH, assessing the patient’s language function with the Korean version of Western Aphasia Battery.…”

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confidence: 99%